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\"Though they serve in many roles and under many titles, no one doubts that political staffs now wield substantial influence in the making of government policy. Backrooms and Beyond draws on interviews with ministers, senior public servants, and political advisers to offer the first detailed Canadian treatment of how that influence is gained and exercised in the policy making process. A comparative analysis of case studies from three Canadian jurisdictions, including the federal Prime Minister's Office, two premier's offices, and ministers' offices, the book presents a detailed account of partisan advisers' involvement in policy work and a new theoretical framework for understanding this work and its impact. As Jonathan Craft shows, partisan advisers often engage in policy work with public servants, outside stakeholders, and often in types of policy work that public servants cannot. Backrooms and Beyond is a rich and rigorous look at an important aspect of contemporary Canadian politics, essential reading for scholars and practitioners, journalists, students of the Westminster system from around the world, and those wanting to understand just how policy is made today.\"-- Provided by publisher.

Garlic, Allium sativum, is broadly used around the world for its numerous culinary and medicinal uses. Wild garlic, Allium vineale, has been used as a substitute for garlic, both in food as well as in herbal medicine. The present study investigated the chemical compositions of A. sativum and A. vineale essential oils. The essential oils from the bulbs of A. sativum, cultivated in Spain, were obtained by three different methods: laboratory hydrodistillation, industrial hydrodistillation, and industrial steam distillation. The essential oils of wild-growing A. vineale from north Alabama were obtained by hydrodistillation. The resulting essential oils were analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Both A. sativum and A. vineale oils were dominated by allyl polysulfides. There were minor quantitative differences between the A. sativum oils owing to the distillation methods employed, as well as differences from previously reported garlic oils from other geographical locations. Allium vineale oil showed a qualitative similarity to Allium ursinum essential oil. The compositions of garlic and wild garlic are consistent with their use as flavoring agents in foods as well as their uses as herbal medicines. However, quantitative differences are likely to affect the flavor and bioactivity profiles of these Allium species.

With the 30th anniversary of the policy advisory systems concept on the horizon, it is an appropriate time to reflect further on the concept’s utility, particularly in helping to understand the dynamics of system change and their implications for policymaking. This article provides diachronic analysis of the policy advisory systems in the classic Anglo-Saxon ‘Westminster’ family (Canada, UK, Australia, New Zealand). Analysis focuses on five advisory units: the public service and central agencies, partisan ministerial advisers, external consultants, commissions of inquiry, and select special advisory bodies. The principle research aim is to compare these cases to shed light on advisory system dynamics through identification and analysis of shared and countryspecific patterns of PAS change. We argue that the leading dynamics of politicization and externalization often used to characterize how advisory systems change masks idiosyncratic country patterns. We argue that differences in the tempo, intensity, and sequencing of advisory unit (de)institutionalization are clear in these cases and that attention to these dimensions of advisory system change add precision to understanding the organization, operation, and evolution of these systems.

\"Policy Work in Canada is an in-depth study into the levels of analytical capacity found within the federal and provincial governments as well as the non-governmental sector. By focusing on the individuals who craft public policy in Canada, this collection of eighteen chapters broadens and deepens our understanding of policy development in Canada. The contributors to this volume examine such topics as: the inherent characteristics of sophisticated policy analysis, the constraints that influence the outcome or style of analysis, the influence of policy analysis on democratic debate, and the lessons that can be learned from different jurisdictions within and outside of Canada. Policy Work in Canada provides a pathway for academics and public managers alike to meet the challenges involved in crafting more nuanced and sophisticated public policy head-on.\"-- Provided by publisher.

Ocean acidification (OA) can alter the development and physiology of many marine organisms. In addition to calcified invertebrates, studies documenting the responses of calcareous algae are critical because of their prominent role in habitat structure and carbonate production within coastal environments. While many studies report physiological responses, few have examined how OA might ultimately alter interactions with generalist herbivores via shifts in algal chemistry. This study describes a series of experiments that examine the influence of OA on the growth and herbivore defensive compounds of calcareous green algae (Halimeda spp.). One experiment was conducted in an open, outdoor seawater system with H. opuntia, while the other was conducted in an indoor, closed system with H. incrassata and H. simulans. Both experiments were conducted over similar ranges in pCO₂ (300 to 2400 μatm) and monitored shifts in calcification and herbivore defenses (calcium carbonate [CaCO₃] and terpenoid metabolite content). Feedings assays with common sea urchins (Lytechinus variegatus and Diadema antillarum) were further conducted to test the degree to which shifts in algal chemistry influence herbivore feeding preferences. Our results were variable among Halimeda spp., highlighting that OA-induced shifts in chemical composition are species-specific. OA reduced the CaCO₃ content (% dry wt) of H. incrassata yet had no effect on H. opuntia or H. simulans. Terpenoid metabolite concentrations were unaltered by pCO₂ for all species. Assays with sea urchins revealed that feeding significantly increased on diets of lower CaCO₃ and secondary metabolite content. Our work suggests that certain algal species may be relatively more susceptible to OA-induced shifts in chemical composition, and those shifts have the potential to weaken the efficacy of herbivore defenses. Future research on how OA influences marine plant–herbivore interactions will improve our broader understanding of how OA stands to alter community and ecosystem properties.

This article develops the concept of policy advisory system (PAS) management in recognition of the need to better theorise and empirically study how governments approach the complex systems of advice around them. In our analysis, we go beyond the conceptualisation of degrees of government’s “control” over advisory sources. We use the dimensions of government agency and discretion and argue that PAS management falls into four forms: authoritative, dependent, laissez-faire, or absent. Using evidence from Australia, Canada, Britain, and New Zealand, we explore how governments operationalise these approaches through a range of choices and practices. The analysis points to the need to recognise that attempts to manage these systems occur both proactively and reactively with clear differences in the broad or narrow scope of management efforts.

Background Healthcare providers increasingly use information about pathogenic variants in cancer predisposition genes, including sequence variants and large rearrangements (LRs), in medical management decisions. While sequence variant detection is typically robust, LRs can be difficult to detect and characterize and may be underreported as a cause for hereditary cancer risk. This report describes the outcomes of hereditary cancer genetic testing using a comprehensive strategy that employs next-generation sequencing (NGS) for LR detection, coupled with LR confirmation using repeat hybrid capture NGS, microarray comparative genomic hybridization (microarray-CGH), and/or multiplex ligation-dependent probe amplification (MLPA). Methods Sequencing and LR analysis were conducted in a consecutive series of 376,159 individuals who received clinical testing with a hereditary pan-cancer gene panel from September 2013 through May 2017. NGS dosage analysis was used to evaluate potential deletions or duplications, with controls in place to exclude pseudogene reads. Samples positive for a putative LR based on NGS were confirmed using a comprehensive approach that included targeted microarray-CGH and/or MLPA analysis, with further examination as needed to ascertain the nature of the LR. Results A total of 3461 LRs were identified and classified as a deleterious mutation (DM), suspected deleterious mutation (SDM) or variant of uncertain significance. Pathogenic LRs (DM/SDM) accounted for the majority of LRs (67.7%), the largest proportion of which were deletions (86.1%), followed by duplications (11.3%), insertions (1.8%), triplications (0.5%), and inversions (0.3%). Several cases presented illustrate that the laboratory approach employed here can ensure consistent identification and accurate characterization of LRs. In the absence of this comprehensive testing strategy, 9% of LRs identified in this testing population might have been missed, potentially leading to inappropriate medical management in as many as 210 individuals referred for hereditary cancer testing. Conclusions These data show that copy number analysis using NGS coupled with confirmatory testing reliably detects and characterizes LRs. Further, LRs comprise a substantial proportion (7.2%) of pathogenic variants identified by the test. A robust and accurate LR identification strategy is an essential component of a high-quality genetic testing program, enabling clinicians to optimize patient medical management decisions.

Most studies of policy formulation focus on the nature and kind of advice provided to decision-makers and think of this as originating from a system of interacting elements: a “policy advisory system”. Policy influence in such models has historically been viewed as based on considerations of the proximate location of policy advisors vis à vis the government, linked to related factors such as the extent to which governments are able to control sources of advice. While not explicitly stated, this approach typically presents the content of policy advice as either partisan “political” or administratively “technical” in nature. This article assesses the merits of these locational models against evidence of shifts in governance arrangements that have blurred both the inside vs outside and technical vs political dimensions of policy formulation environments. It argues that the growing plurality of advisory sources and the polycentrism associated with these governance shifts challenge the utility of both the implied content and locational dimensions of traditional models of policy advice systems. A revised approach is advanced that sees influence more as a product of content than location. The article concludes by raising several hypotheses for future research linking advisory system behaviour to governance arrangements.

A growing corpus of empirical findings suggests that appointed partisan advisers are established and influential policy actors within the executive. Their policy work has long attracted concerted attention with respect to issues of accountability and politicization. Less attention however has been cast to concept and theory building, to link empirical findings with extant policy theory. This article presents careful analysis of the leading conceptual approaches to the study of these policy workers. It offers a critique of these approaches but suggests they share common logic and identify common attributes that can usefully be synthesized into a new framework. A framework is then advanced through the elaboration of four key concepts: buffering, bridging, moving, and shaping to focus on the substantive and procedural nature of partisan advisers' policy work. Combined with additional criteria, these are used to develop two subsidiary frameworks focusing on partisan advisers' policy advisory and policy process participation. The study of these actors is argued to not only benefit from improved linkages with policy theory, but that policy theory itself may be improved through focused study of these unique, politically appointed, policy workers.