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Background: The body roundness index (BRI) offers a more precise evaluation of body fat and visceral fat levels. However, studies on the relationship between BRI and the risk of cardiovascular disease (CVD) remain limited. Methods: Survival differences across BRI quartiles were estimated using Kaplan-Meier analysis. The association between the BRI and the risk of CVD was examined through Cox proportional hazards and restricted cubic spline (RCS) models. Additional subgroup and sensitivity analyses were also conducted. Results: This study included 6401 patients (47.43% male), with an incidence of CVD of 17.51%. Kaplan-Meier survival analysis revealed statistically significant differences between groups based on the assigned BRI quartiles. Cox models revealed a strong association between the BRI and CVD risk, while RCS models showed a non-linear link between higher BRIs and increased CVD risk. In certain subgroups, an elevated BRI was closely correlated with an increased incidence of CVD. Notable interactions were found between BRI and gender, age, hypertension, diabetes, alcohol consumption, and smoking status. Sensitivity analysis excluding early CVD cases yielded consistent results. Conclusion: A significant non-linear association was found between the BRI and CVD risk. The BRI could be a valuable and sensitive marker for identifying individuals at high risk of CVD, with varying predictive value across different population subgroups.

Background Polycyclic aromatic hydrocarbons (PAHs) and its DNA adducts has been suggested to increase the risk of preterm birth (PB). Yet, few studies have been conducted to investigate this association, and the role of dietary nutrients intakes including vitamins, folate, and carotene during pre- and post-conception on this association has not been studied. Methods Building upon a birth cohort in Taiyuan China, we conducted a nested case control study including 83 PB and 82 term births. Benzo[a]pyrene (BaP)-DNA adducts were measured by an improved LC-MC/MC analytic method. Dietary nutrient intakes were estimated from food frequency questionnaire using the Chinese Standard Tables of Food Consumption. Multivariable logistic regression model was used to examine the associations. Results Increased risk of PB was observed as per interquartile increase in maternal BaP-DNA adduct level (OR = 1.27, 95%CI 0.95–1.67). Compared to low level (below mean) of maternal adducts, high level (above mean) of adducts was associated with the risk of PB (OR = 2.05, 95%CI 1.05–4.01). After stratified by dietary nutrients intakes, high adducts levels were associated with approximately 2–fourfold times increases in risk of PB among women with low vitamin A, C, E, folate, and carotene intakes during pre- and/or post-conception. Stronger stratified associations were consistently seen during preconception. Similar patterns were observed after additional adjustment for supplementation. Conclusions Our study supports the hypothesis that high level of maternal PAHs exposure was significantly associated with increased risk of PB, and provides the first evidence that dietary vitamins, carotene, and folate intake levels may modify this association during different pregnancy windows. Our findings are relevant to identify recommendation for environment management and prenatal nutrition regarding pregnant women and newborns. Further investigation in other populations is warranted.

Extensive use of gallium arsenide (GaAs) has led to increased exposure to humans working in the semiconductor industry. This study employed physicochemical characterization of GaAs obtained from a workplace, cytotoxicity analysis of damage induced by GaAs in 16HBE cells, RNA-seq and related bioinformatic analysis, qRT-PCR verification and survival analysis to comprehensively understand the potential mechanism leading to lung toxicity induced by GaAs. We found that GaAs-induced abnormal gene expression was mainly related to the cellular response to chemical stimuli, the regulation of signalling, cell differentiation and the cell cycle, which are involved in transcriptional misregulation in cancer, the MAPK signalling pathway, the TGF-β signalling pathway and pulmonary disease-related pathways. Ten upregulated genes (FOS, JUN, HSP90AA1, CDKN1A, ESR1, MYC, RAC1, CTNNB1, MAPK8 and FOXO1) and 7 downregulated genes (TP53, AKT1, NFKB1, SMAD3, CDK1, E2F1 and PLK1) related to GaAs-induced pulmonary toxicity were identified. High expression of HSP90AA1, RAC1 and CDKN1A was significantly associated with a lower rate of overall survival in lung cancers. The results of this study indicate that GaAs-associated toxicities affected the misregulation of oncogenes and tumour suppressing genes, activation of the TGF-β/MAPK pathway, and regulation of cell differentiation and the cell cycle. These results help to elucidate the molecular mechanism underlying GaAs-induced pulmonary injury.

The horizontal fractures in the strata will close in the compaction effect of overlying strata, while the vertical cracks are widely developed, which can be equivalent to HTI (transverse isotropy with a horizontal axis of symmetry) medium. When an S-wave propagates into HTI media, the shear wave will divide into two types of waves: a fast S-wave and slow S-wave. When the strata of HTI are thin and overlapping, called the thin interbeds model, the wave field exhibits complex primary reflections, converted waves, and multiples. We introduce a new second-order approximation of the total reflection coefficient, with the incidence angle lower than the critical angle in thin-interbed HTI media using a recursive algorithm. We verify the effectiveness of the second-order approximation by analyzing the energy of multiples. Comparing the second-order approximate solution that degenerates the HTI medium into isotropic and Kennett’s exact solution, we find that our solution has an accuracy of over 99.9% in any azimuth, with the incidence angle lower than the critical angle under P-wave incidence. However, our solution of the SP wave field is suitable for incidence azimuth angles between 0–75° and 120–180°, with the lowest accuracy occurring at an incidence angle of 25° and a relative error of 6.4%. The approximate solution in the SS wave field has the same applicable range as the SP wave, with the maximum error of 6.3% occurring at the incident angle of 1°. This new second-order approximate formula for the total reflection coefficient of thin interbeds composed of HTI helps us to understand the reflection characteristics of complex thin interbeds. It also lays a theoretical foundation for the development of AVO (Amplitude Versus Offset) analysis and inversion techniques for lithological and stratigraphic oil and gas reservoirs.

Urinary benzene metabolites trans, trans-muconic acid (t, t-MA), and S-phenyl mercapturic acid (S-PMA) are often used as biomarkers of internal exposure to benzene. However, there are few reports on using urinary benzene metabolites to estimate airborne benzene concentrations in individuals exposed to benzene. In this study, t, t-MA, and S-PMA were analyzed by UPLC-MS/MS, and a simple pharmacokinetic model was used to calculate the daily intake (DI) of benzene based on the levels of urinary t, t-MA, and S-PMA in occupational individuals. The back-calculated airborne benzene levels (BCABL) were obtained from the DI of benzene. Among the exposed subjects (n = 84), the median BCABL (3.67 mg/m3) based on t, t-MA was very close to the median level of measured airborne benzene (3.27 mg/m3, p = 0.171), and there was no effect of smoking or dietary habits on t, t-MA-based BCABL. In the control subjects (n = 49), the levels of measured airborne benzene were all below the quantitation limit (0.024 mg/m3), and the BCABL (0.002–0.25 mg/m3) calculated by S-PMA was close to this background level. Our study suggests that the t, t-MA-based BCABL can reflect the actual airborne benzene level in a range of 1.10–86.91 mg/m3 and that the S-PMA-based BCABL is more reliable for non-professional benzene exposure.

Aims/Introduction Previous studies have shown that glucose peak time during the oral glucose tolerance test varies in type 2 diabetes patients; however, characteristics of this heterogeneity remain unclear. This research aimed to investigate the characteristics of delayed glucose peak time in type 2 diabetes. Materials and Methods A total of 178 participants who underwent the oral glucose tolerance test were divided into five groups according to glucose peak time. Results A total of 25 participants with normal glucose tolerance had a glucose peak at 30 min. Among participants with type 2 diabetes, 28 had a glucose peak at 60 min, 48 at 90 min, 45 at 120 min and 32 at 150 min. With the glucose peak time delayed, glycated hemoglobin, area under the glucose curve and homeostatic model assessment of insulin resistance increased gradually (P = 0.038, P < 0.0001, P < 0.0001, respectively), and oral glucose insulin sensitivity, homeostatic model assessment of β‐cell function, insulinogenic index, modified β‐cell function index and disposition indices decreased (P < 0.0001 for all). On multinominal logistic regression, insulinogenic index (odds ratio 0.73, 95% confidence interval 0.57–0.93, P = 0.01), modified β‐cell function index (odds ratio 0.67, 95% confidence interval 0.47–0.94, P = 0.023) and oral glucose insulin sensitivity (odds ratio 0.91, 95% confidence interval 0.87–0.96, P < 0.0001) were independently correlated with delayed glucose peak time. Conclusions Delay in glucose peak time indicated an increase in blood glucose and a decrease in insulin sensitivity and secretion. Furthermore, insulinogenic index, modified β‐cell function index and oral glucose insulin sensitivity contributed to delayed glucose peak time. The purpose of this research was to investigate the characteristics of delayed glucose peak time of type 2 diabetes. Along with the delay of glucose peak time, blood glucose increased while insulin sensitivity and secretion decreased. Insulinogenic index, modified beta‐cell function index, oral glucose insulin sensitivity contributed to delayed glucose peak time.

In recent years, the Swept-Source Phase Microscope (SS-PM) has gained more attention due to its greater robustness to sample motion and lower signal decay with depth. However, the mechanical wavelength tuning of the swept source creates small variations in the wavenumber sampling of spectra that introduce serious phase noise. We present a software post-processing method to eliminate phase noise in SS-PM. This method does not require high-quality swept light sources or high-precision synchronization devices and achieves ~72 pm displacement sensitivity using a conventional SS-PM system. We compare the performance of this method with traditional software-based methods by measuring phase fluctuations. The phase fluctuations in the traditional software-based method are five times those of the proposed method, which means the proposed method has better sensitivity. Using this method, we reconstructed phase images of air wedges and resolution plates to demonstrate the SS-PM’s potential for high-sensitivity surface profiling measurement. Finally, we discuss the advantages of SS-PM over traditional Spectral-Domain PM techniques.

Dysimmunity plays a key role in diabetes, especially type 1 diabetes mellitus. Islet-specific autoantibodies (ISAs) have been used as diagnostic markers for different phenotypic classifications of diabetes. This study was aimed to explore the relationships between ISA titers and the clinical characteristics of diabetic patients. A total of 509 diabetic patients admitted to Department of Endocrinology and Metabolism at the Affiliated Hospital of Nantong University were recruited. Anthropometric parameters, serum biochemical index, glycosylated hemoglobin, urinary microalbumin/creatinine ratio, ISAs, fat mass, and islet β-cell function were measured. Multiple linear regression analysis was performed to identify relationships between ISA titers and clinical characteristics. Compared with autoantibody negative group, blood pressure, weight, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), visceral fat mass, fasting C-peptide (FCP), 120 minutes C-peptide (120minCP) and area under C-peptide curve (AUCCP) of patients in either autoantibody positive or glutamate decarboxylase antibody (GADA) positive group were lower. Body mass index (BMI), waist circumference, triglycerides (TGs), body fat mass of patients in either autoantibody positive group were lower than autoantibody negative group. GADA titer negatively correlated with TC, LDL-C, FCP, 120minCP, and AUCCP. The islet cell antibody and insulin autoantibody titers both negatively correlated with body weight, BMI, TC, TG, and LDL-C. After adjusting confounders, multiple linear regression analysis showed that LDL-C and FCP negatively correlated with GADA titer. Diabetic patients with a high ISA titer, especially GADA titer, have worse islet β-cell function, but less abdominal obesity and fewer features of the metabolic syndrome.