Journal Article

Effects of Benzoapyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Zhao, Nan, Feng, Yongliang, Zhang, Yawei, Cui, Shiwei, Li, Haibin, Wang, Suping, Wu, Weiwei, Guo, Ling

2022

Overview

Background Polycyclic aromatic hydrocarbons (PAHs) and its DNA adducts has been suggested to increase the risk of preterm birth (PB). Yet, few studies have been conducted to investigate this association, and the role of dietary nutrients intakes including vitamins, folate, and carotene during pre- and post-conception on this association has not been studied. Methods Building upon a birth cohort in Taiyuan China, we conducted a nested case control study including 83 PB and 82 term births. Benzo[a]pyrene (BaP)-DNA adducts were measured by an improved LC-MC/MC analytic method. Dietary nutrient intakes were estimated from food frequency questionnaire using the Chinese Standard Tables of Food Consumption. Multivariable logistic regression model was used to examine the associations. Results Increased risk of PB was observed as per interquartile increase in maternal BaP-DNA adduct level (OR = 1.27, 95%CI 0.95–1.67). Compared to low level (below mean) of maternal adducts, high level (above mean) of adducts was associated with the risk of PB (OR = 2.05, 95%CI 1.05–4.01). After stratified by dietary nutrients intakes, high adducts levels were associated with approximately 2–fourfold times increases in risk of PB among women with low vitamin A, C, E, folate, and carotene intakes during pre- and/or post-conception. Stronger stratified associations were consistently seen during preconception. Similar patterns were observed after additional adjustment for supplementation. Conclusions Our study supports the hypothesis that high level of maternal PAHs exposure was significantly associated with increased risk of PB, and provides the first evidence that dietary vitamins, carotene, and folate intake levels may modify this association during different pregnancy windows. Our findings are relevant to identify recommendation for environment management and prenatal nutrition regarding pregnant women and newborns. Further investigation in other populations is warranted.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adducts / Benzo(a)pyrene / Benzo(a)pyrene - analysis / Benzopyrene / Birth Cohort / Birth weight / Blood / Carotene / Carotenes / Carotenoids / Case-Control Studies / Cell division / Childbirth & labor / China - epidemiology / Deoxyribonucleic acid / Dietary intake / Dietary supplements / DNA / DNA Adducts / DNA methylation / Earth and Environmental Science / Environment / Environmental aspects / Environmental Epidemiology / Environmental Health / Environmental management / Female / Fetuses / Folate / Folic Acid / Food / Food and nutrition / Food consumption / Food intake / Genetic aspects / Gestational age / Hazardous materials / Health aspects / Hospitals / Humans / Infant, Newborn / Investigations / Male / Neonates / Nutrients / Nutrition / Occupational Medicine/Industrial Medicine / Polycyclic Aromatic Hydrocarbons / Population / Pregnancy / Pregnant women / Premature birth / Premature Birth - chemically induced / Premature Birth - epidemiology / Prenatal influences / Preterm birth / Prevention / Public Health / Pyrene / Questionnaires / Regression models / Risk / Risk factors / Sample size / Vitamin A / Vitamin B / Vitamins / Womens health