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This double-blind trial involving 387 women with recurrent candidiasis evaluated the effectiveness of a regimen of 150 mg of oral fluconazole once per week. Six months after the completion of therapy, 90.8 percent of the women in the fluconazole group remained free of candidiasis, as compared with 35.9 percent in the placebo group. This double-blind trial evaluated the effectiveness of a regimen of oral fluconazole once per week. Since recurrent vulvovaginal candidiasis is estimated to occur in 5 to 8 percent of women during their reproductive years, millions of women worldwide are affected by the condition. 1 – 3 Not considered a typical sexually transmitted infection, recurrent vulvovaginal candidiasis affects immunocompetent, healthy women in all strata of society. 2 , 4 Although the condition has several causes, the majority of women with recurrent infection have no recognizable risk factors. 5 , 6 Frequent recurrences of symptomatic vulvovaginitis result in considerable suffering and cost and have a markedly negative effect on sexual relations. 7 Management approaches include treatment of each individual episode or use of prophylactic . . .