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Alfred the Great is, without a doubt, an important figure not only in English history, but also in that of the European Middle Ages. His policies for dealing with the Nordic invasion of England, as well as his cultural, educational and legal reforms, have made this king a revered figure in English intellectual circles, especially in the 19th century. It is striking that, in spite of his popularity, this monarch does not have a more prominent presence within audiovisual media, which is the artistic mass media par excellence of the twentieth and twenty-first century. The objective of the present work is to investigate the historical popularity and audiovisual trajectory of this king, as well as to analyze his representation in the cinema and television productions that have dealt with him. Alfredo el Grande es, sin duda, una figura importante no solo de la historia inglesa, sino de la propia Edad Media europea. Sus políticas para hacer frente a la invasión nórdica de Inglaterra, así como sus reformas culturales, educativas y jurídicas, han convertido a este rey en un personaje reverenciado en los círculos intelectuales ingleses, sobre todo en el siglo XIX. Resulta llamativo que aun así este monarca no tenga una presencia mucho más destacada dentro de los medios cinematográficos y audiovisuales, los medios artísticos de masas por antonomasia del siglo XX y XXI. Es justo el objetivo del presente trabajo trazar la trayectoria mediática y popular de este rey, así como analizar su representación y construcción en las producciones audiovisuales que han tratado su figura.

Alfredo el Grande es, sin duda, una figura importante no solo de la historia inglesa, sino de la propia Edad Media europea. Sus políticas para hacer frente a la invasión nórdica de Inglaterra, así como sus reformas culturales, educativas y jurídicas, han convertido a este rey en un personaje reverenciado en los círculos intelectuales ingleses, sobre todo en el siglo XIX. Resulta llamativo que aun así este monarca no tenga una presencia mucho más destacada dentro de los medios cinematográficos y audiovisuales, los medios artísticos de masas por antonomasia del siglo XX y XXI. Es justo el objetivo del presente trabajo trazar la trayectoria mediática y popular de este rey, así como analizar su representación y construcción en las producciones audiovisuales que han tratado su figura.

The thraustochytrid Aurantiochytrium limacinum SR21 is a promising source of docosahexaenoic acid (DHA) for human consumption as dietary supplement, replacing traditional fish oil. This work deals with the production of structured triacylglycerols (STAGs) with caprylic acid (CA) located at sn-1,3 positions and DHA at sn-2 position of the glycerol molecule. This process is conducted by acidolysis of CA and A. limacinum SR21 oil catalyzed by Lipozyme TL-IM and Lipozyme RM-IM. A central composite design with response surface was used to optimize the reaction temperature and the intensity of treatment (IOT). Statistical models adequately describe the reaction behavior (R2 > 0.91). The optimal temperature values were 37 °C for both lipases. Additionally, IOTs of 9.02 and 7.87 g lipase h g−1 TAG were stablished for TL-IM and RM-IM, respectively. The reaction was scaled up by multiplying the amounts of A. limacinum oil, CA, lipase, and hexane (used as reaction medium) by a factor of 20 while maintaining the IOTs constant. TL-IM showed a better performance to catalyze the acidolysis reaction than RM-IM, achieving 40.8 mol% of total CA incorporated (91.2% of total incorporated at sn-1,3 positions), while the palmitic acid (PA) content at sn-1,3 positions decreased from 77.3 to 20.4 mol%. DHA represented 45.5 mol% of fatty acids at sn-2 position and 15.7 mol% of fatty acids at sn-1,3 positions. Using RM-IM, STAGs of similar composition were obtained.

Quadruple aberrant hyperphosphorylated tau, beta-amyloid, α-synuclein and TDP-43 neuropathology and metal solid nanoparticles (NPs) are documented in the brains of children and young adults exposed to Metropolitan Mexico City (MMC) pollution. We investigated environmental NPs reaching noradrenergic and dopaminergic nuclei and the cerebellum and their associated ultrastructural alterations. Here, we identify NPs in the locus coeruleus (LC), substantia nigrae (SN) and cerebellum by transmission electron microscopy (TEM) and energy-dispersive X-ray spectrometry (EDX) in 197 samples from 179 MMC residents, aged 25.9 ± 9.2 years and seven older adults aged 63 ± 14.5 years. Fe, Ti, Hg, W, Al and Zn spherical and acicular NPs were identified in the SN, LC and cerebellar neural and vascular mitochondria, endoplasmic reticulum, Golgi, neuromelanin, heterochromatin and nuclear pore complexes (NPCs) along with early and progressive neurovascular damage and cerebellar endothelial erythrophagocytosis. Strikingly, FeNPs 4 ± 1 nm and Hg NPs 8 ± 2 nm were seen predominantly in the LC and SN. Nanoparticles could serve as a common denominator for misfolded proteins and could play a role in altering and obstructing NPCs. The NPs/carbon monoxide correlation is potentially useful for evaluating early neurodegeneration risk in urbanites. Early life NP exposures pose high risk to brains for development of lethal neurologic outcomes. NP emissions sources ought to be clearly recognized, regulated, and monitored; future generations are at stake.

This paper presents a high performance vision-based system with a single static camera for traffic surveillance, for moving vehicle detection with occlusion handling, tracking, counting, and One Class Support Vector Machine (OC-SVM) classification. In this approach, moving objects are first segmented from the background using the adaptive Gaussian Mixture Model (GMM). After that, several geometric features are extracted, such as vehicle area, height, width, centroid, and bounding box. As occlusion is present, an algorithm was implemented to reduce it. The tracking is performed with adaptive Kalman filter. Finally, the selected geometric features: estimated area, height, and width are used by different classifiers in order to sort vehicles into three classes: small, midsize, and large. Extensive experimental results in eight real traffic videos with more than 4000 ground truth vehicles have shown that the improved system can run in real time under an occlusion index of 0.312 and classify vehicles with a global detection rate or recall, precision, and F-measure of up to 98.190%, and an F-measure of up to 99.051% for midsize vehicles.

In this study, allele frequencies were determined in a Peruvian population for application to human identification. A population of 601 unrelated individuals was analyzed (400 individuals with the GlobalFiler Express kit and 201 individuals with the VeriFiler Express kit). The locus with the highest power of discrimination (PD) was SE33 (0.9851, 31 alleles), while the least polymorphic locus was D22S1045 (0.75810, 11 alleles). The PE in a similar fashion ranged from 0.2421 (D22S1045) to 0.7818 (SE33). Under the assumption of independence, the combined PD was > 0.9999999999 while the combined PE = 0.9999999933. When comparing the population studied with different populations of Latin America, the greatest Fst genetic distance was obtained with a Venezuelan population (0.052), and the shortest distance was with a Bolivian and Peruvian population (0.004).

Parkinson’s disease involves widespread neurodegeneration that extends far beyond the basal ganglia, giving rise to a diverse range of non-motor symptoms that frequently emerge before motor onset. These include autonomic dysfunction, cognitive decline, neuropsychiatric disturbances, sleep-related disorders, and sensory deficits. Here, we synthesize current evidence on the anatomical, neurochemical, and network-level mechanisms that drive these symptoms, and we examine how they shape disease progression and clinical heterogeneity. We highlight the limitations of dopamine-centric models and advocate for a framework that treats non-motor symptoms as the disorder’s primary, mechanistically distinct features. We also discuss how emerging technologies—such as multi-omic profiling, artificial intelligence, and network neuroscience—enable earlier identification, stratification of non-motor phenotypes, and the development of precision-based therapeutic strategies. Recognizing non-motor symptoms as central to Parkinson’s disease redefines how the disorder should be diagnosed, studied, and treated.

A bstract There exists a vast literature examining the electroweak (EW) fine-tuning problem in supersymmetric scenarios, but little concerned with the dark matter (DM) one, which should be combined with the former. In this paper, we study this problem in an, as much as possible, exhaustive and rigorous way. We have considered the MSSM framework, assuming that the LSP is the lightest neutralino, χ 1 0 , and exploring the various possibilities for the mass and composition of χ 1 0 , as well as different mechanisms for annihilation of the DM particles in the early Universe (well-tempered neutralinos, funnels and co-annihilation scenarios). We also present a discussion about the statistical meaning of the fine-tuning and how it should be computed for the DM abundance, and combined with the EW fine-tuning. The results are very robust and model-independent and favour some scenarios (like the h-funnel when M χ 1 0 is not too close to m h / 2) with respect to others (such as the pure wino case). These features should be taken into account when one explores “natural SUSY” scenarios and their possible signatures at the LHC and in DM detection experiments.

Purpose Both venous and arterial thrombotic events (VTE/AT) can be associated with immune checkpoint inhibitors (ICI). However, there is a paucity of information apropos patients in routine clinical practice. Methods/patients Retrospective, multicenter study promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM). Individuals with kidney or bladder cancer who initiated ICI between 01/01/2015 and 12/31/2020 were recruited. Minimum follow-up was 6 months (except in cases of demise). The primary objective was to calculate the incidence of ICI-associated VTE/AT and secondary objectives included to analyze their impact on survival and identify variables predictive of VTE/AT. Results 210 patients with kidney cancer were enrolled. The incidence of VTE/AT during follow-up (median 13 months) was 5.7%. Median overall survival (OS) was relatively lower among subjects with VTE/AT (16 months, 95% CI 0.01–34.2 vs. 27 months, 95% CI 22.6–31.4; p  = 0.43). Multivariate analysis failed to reveal predictive variables for developing VTE/ AT. 197 patients with bladder were enrolled. There was a 9.1% incidence rate of VTE/AT during follow-up (median 8 months). Median OS was somewhat higher in patients with VTE/AT (28 months, 95% CI 18.4–37.6 vs 25 months, 95% CI 20.7–29.3; p  = 0.821). Serum albumin levels < 3.5 g/dl were predictive of VTE/ AT ( p  < 0.05). Conclusions There appears to be no association between developing VTE/AT and ICI use in patients with renal or bladder cancer. Serum albumin levels are a predictive factor in individuals with bladder cancer.

Introduction/objectivesReproductive labour refers to activities and tasks directed at caregiving and domestic roles, such as cleaning, cooking, and childcare. Productive labour refers to activities that involve economic remuneration. The aim of the present study was to analyse physical activity, sedentary behaviour, physical fitness, and cognitive performance in women with fibromyalgia who engaged, or did not engage, in productive work.MethodThis cross-sectional study comprised 276 women with fibromyalgia from Andalusia (southern of Spain). Levels of physical activity (light, moderate, and vigorous) and sedentary behaviour were measured by an accelerometer. Physical fitness and cognitive performance were measured with a battery of performance-based tests.ResultsMore hours/week of homemaker-related tasks were associated with higher time spend in light physical activity and lower sedentary behaviour (P < 0.001 and P < 0.05, respectively). Furthermore, in comparison with those who only engaged in reproductive labour, women with fibromyalgia who engaged in productive work showed lower levels of sedentary behaviour and higher levels of light and moderate physical activity, physical fitness (except muscular strength), and cognitive performance (all, P < 0.05).ConclusionsAltogether, our findings suggest that productive work is consistently related to better physical and cognitive functioning in women with fibromyalgia. If future research corroborates causality of our findings, then, to maintain women with fibromyalgia engaging in productive work may be strived for not only because of societal or economic reasons but also for better health. However, we should keep in mind that people with fibromyalgia have a chronic condition, and therefore, adaptations at the workplace are imperative.Key Points• Women with fibromyalgia, who spend more time in reproductive labour, have higher levels of light physical activity and lower sedentary behaviour; however, it is associated with poorer general health (as lower physical fitness or cognitive performance).• Household tasks are often seen as a responsibility associated with the gender roles that women with fibromyalgia perform, despite the feelings of incapacity they cause. Policies focused on reducing reproductive labour demands for fibromyalgia patients (i.e. social help on housework or childcare) might facilitate the inclusion of daily active behaviours.• People with fibromyalgia who engage in productive work seem to have better health outcomes than those who have not; however, we cannot forget that adaptations and flexibility at the workplace are imperative.