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Il était une fois un mot
«Une collaboration entre le poète Nicolas Lauzon (auteur de quatre recueils de poèmes parus aux éditions du passage) et la linguiste de formation Marijo Denis. Un album découverte pour les 8 ans et plus, pour s'éveiller aux plaisirs de l'étymologie et de la linguistique de façon ludique ! Enfants et parents y apprendront d'où viennent les mots que nous utilisons au quotidien, quelle est leur histoire, leur parcours, et comment ils se construisent. Plusieurs sections thématiques : mots gourmands (biscuit, bretzel), mots d'animaux (sanglier, renard), mots du jardin (pelouse, tulipe), mots du ciel (comète, satellite), mots de voyage (passeport). L'origine de chaque mot est mise en poème par Nicolas Lauzon, contextualisée par Marijo Denis, et mis en image par une illustration graphique et ludique.»-- Publisher.
Book
Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination
Background
HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such as DCAF1-Cul4A E3 ligase complex) to target many host proteins and interfere with their functions. Among them, Vpr binds the uracil DNA glycosylase UNG2, which controls genome uracilation, and induces its specific degradation leading to loss of uracil removal activity in infected cells. Considering the essential role of UNG2 in antibody diversification in B-cells, we evaluated the impact of Vpr on UNG2 fate in B lymphocytes and examined the functional consequences of UNG2 modulations on class switch recombination (CSR).
Methods
The impact of Vpr-induced UNG2 deregulation on CSR proficiency was evaluated by using virus-like particles able to deliver Vpr protein to target cells including the murine model CSR B cell line CH12F3 and mouse primary B-cells. Co-culture experiments were used to re-examine the ability of Vpr to be released by HIV-1 infected cells and to effectively accumulate in bystander B-cells. Vpr-mediated UNG2 modulations were monitored by following UNG2 protein abundance and uracil removal enzymatic activity.
Results
In this study we report the ability of Vpr to reduce immunoglobulin class switch recombination (CSR) in immortalized and primary mouse B-cells through the degradation of UNG2. We also emphasize that Vpr is released by producing cells and penetrates bystander B lymphocytes.
Conclusions
This work therefore opens up new perspectives to study alterations of the B-cell response by using Vpr as a specific CSR blocking tool. Moreover, our results raise the question of whether extracellular HIV-1 Vpr detected in some patients may manipulate the antibody diversification process that engineers an adapted response against pathogenic intruders and thereby contribute to the intrinsic B-cell humoral defect reported in infected patients.
Journal Article
AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells
Remodeling of immunoglobulin genes by activation-induced deaminase (AID) is required for affinity maturation and class-switch recombination in mature B lymphocytes. In the immunoglobulin heavy chain locus, these processes are predominantly controlled by the 3' cis-regulatory region. We now show that this region is transcribed and undergoes AID-mediated mutation and recombination around phylogenetically conserved switchlike DNA repeats. Such recombination, which we term locus suicide recombination, deletes the whole constant region gene cluster and thus stops expression of the immunoglobulin of the B cell surface, which is critical for B cell survival. The frequency of this event is approaching that of class switching and makes it a potential regulator of B cell homeostasis.
Journal Article
Mosaics of Alexandria : pavements of Greek and Roman Egypt
\"The art of the mosaic was developed by the Greeks, notably within the royal court of Macedonia, and was initially unknown to the Egyptians. Macedonian mosaicists then established busy workshops in the capital, Alexandria, and in the new towns of Greek Egypt. Under the stimulus of commissions from the Ptolemaic court, these workshops soon showed that they were capable of innovation. Beginning with pebbles, they then used tesserae of different sizes, and adopted new materials (glass, faience, paint) in order to transpose onto the floor images from grand paintings, which was the major art form of the time and was characterized by the vivid use of color. Alexandrian mosaicists were at the forefront of creativity during the Hellenistic period and their influence spread around the Mediterranean. After the Roman conquest of Egypt they adapted to the tastes of their new sponsors and to changes in architecture and were able to retain an important place within this art as it developed across the entire empire, in Rome and from east to west. The Mosaics of Alexandria provides the first overview of the mosaics and pavements of Egypt that were created between the end of the fourth century BC and the sixth century AD. It presents a selection of some seventy mosaics and pavements from Alexandria and Greco-Roman Egypt. Generally little known and more often than not unpublished, these works are illustrated here in full color, some for the first time. The aim is to better understand the artistic and artisanal production of a type of decoration that played an important role within the living environment of the ancients.\"-- Provided by publisher.
Book
Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse
In mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain (
) locus under control of its 3'
-regulatory region (
). The
is itself transcribed and can undergo \"locus suicide recombination\" (LSR), then deleting the constant gene cluster and terminating
expression. The relative contribution of LSR to B cell negative selection remains to be determined.
Here, we set up a knock-in mouse reporter model for LSR events with the aim to get clearer insights into the circumstances triggering LSR. In order to explore the consequences of LSR defects, we reciprocally explored the presence of autoantibodies in various mutant mouse lines in which LSR was perturbed by the lack of Sµ or of the
.
Evaluation of LSR events in a dedicated reporter mouse model showed their occurrence in various conditions of B cell activation, notably in antigen-experienced B cells Studies of mice with LSR defects evidenced increased amounts of self-reactive antibodies.
While the activation pathways associated with LSR are diverse,
as well as
, this study suggests that LSR may contribute to the elimination of self-reactive B cells.
Journal Article
Bangkok dangerous
\"Original Bangkok Dangerous directors Danny and Oxide Pang return to familiar territory with this remake of their own popular 1999 thriller about a ruthless hitman (Nicolas Cage) who travels to Bangkok in order to carry out four crucial jobs. During the course of his missions, the triggerman falls in love with a pretty local girl while also forming a friendly bond with his young errand boy\"--Allmovie.com, viewed November 21, 2017.
DVD
La banque, en pleine transformation
La banque est pleinement entrée dans l’ère des transformations. Attaquée sur ses marchés et ses prés carrés historiques, elle doit aujourd’hui appréhender et répondre aux défis de la réinvention, tout en développant son statut de tiers de confiance privilégié. À l’heure des commodités, à l’heure de la défiance, la banque et, de façon générale, le métier de banquier doivent opérer leurs mues et répondre à la violence des accélérations numériques actuelles, tout en plaçant l’humain au cœur de leurs propositions de services. Nouveaux services, nouvelles offres, nouvelles solutions sont pour la banque autant de défis à relever pour éviter l’ère des périls et le risque, réel, de sa disparition. Proximité, engagement, confiance, sont autant de fondamentaux solides qu’elle se doit de valoriser auprès de ses marchés et de ses clients. Banks in the throes of changePlunged into an era of transformation, attacked in the market and its historical havens, banks now have to anticipate events and reinvent their activities around their status as a trusted third party. In the era of commodities and of distrust, banks (more broadly, bankers) must molt in reaction to the violent acceleration of digital technology but while placing the human factor at the center of the services they propose. New services, new offers, new solutions are, for banks, challenges to be taken up in order to stave off the perils and risks of extinction. Proximity, commitment and confidence are solid, fundamental values that banks must promote in the market and to their customers.
Journal Article
La Banque, en pleine transformation, in : La finance au défi du numérique
La banque est pleinement entrée dans l'ère des transformations. Attaquée sur ses marchés et ses prés carrés historiques, elle doit aujourd'hui appréhender et répondre aux défis de la réinvention, tout en développant son statut de tiers de confiance privilégié. A l'heure des commodités, à l'heure de la défiance, la banque et, de façon générale, le métier de banquier doivent opérer leurs mues et répondre à la violence des accélérations numériques actuelles, tout en plaçant l'humain au coeur de leurs propositions de services. Nouveaux services, nouvelles offres, nouvelles solutions sont pour la banque autant de défis à relever pour éviter l'ère des périls et le risque, réel, de sa disparition. Proximité, engagement, confiance, sont autant de fondamentaux solides qu'elle se doit de valoriser auprès de ses marchés et de ses clients.
Journal Article