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AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells
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AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells
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Journal Article
AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells
2012
Overview
Remodeling of immunoglobulin genes by activation-induced deaminase (AID) is required for affinity maturation and class-switch recombination in mature B lymphocytes. In the immunoglobulin heavy chain locus, these processes are predominantly controlled by the 3' cis-regulatory region. We now show that this region is transcribed and undergoes AID-mediated mutation and recombination around phylogenetically conserved switchlike DNA repeats. Such recombination, which we term locus suicide recombination, deletes the whole constant region gene cluster and thus stops expression of the immunoglobulin of the B cell surface, which is critical for B cell survival. The frequency of this event is approaching that of class switching and makes it a potential regulator of B cell homeostasis.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
Activation-induced cytidine deaminase
/ AIDS
/ Animals
/ Biological and medical sciences
/ Cytidine Deaminase - metabolism
/ Deletion
/ DNA
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Gene Rearrangement, B-Lymphocyte, Heavy Chain
/ Genes
/ Genes, Immunoglobulin Heavy Chain
/ Genetics of the immune response
/ Humans
/ Immunoglobulin Class Switching
/ loci
/ Mice
/ Mutation
/ Regulatory Sequences, Nucleic Acid
/ Repetitive Sequences, Nucleic Acid
/ Suicide
/ Survival
/ Switches
