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This study investigates the effects of Nigella sativa seeds and Nigella sativa honeybee on hypercholesterolemic rats, focusing on blood lipid profile, liver and kidney function, and antioxidant status. A total of 30 male rats were divided into five groups: a healthy control, a hypercholesterolemic group (fed a high-fat diet), and three treated groups receiving Nigella sativa seeds, Nigella honey, or a combination of both for six weeks. Biochemical analyses measured total cholesterol, triglycerides, HDL, LDL, liver enzymes (ALT, AST), kidney markers (urea, creatinine), and antioxidant parameters (SOD, CAT, MDA). Results showed that all treated groups exhibited significant reductions in total cholesterol, triglycerides, and LDL, along with increased HDL levels compared to the untreated hypercholesterolemic group. Liver and kidney function markers improved notably, and antioxidant activity increased. The combined treatment of seeds and honey produced the most pronounced improvements, suggesting a synergistic interaction between the two substances. The study concludes that Nigella sativa seeds and honey possess potent therapeutic and protective effects against hypercholesterolemia and its complications by restoring lipid balance and protecting hepatic and renal tissues from oxidative damage. The researcher recommends utilizing Nigella-based products as natural dietary supplements for lipid regulation and general health, and calls for further clinical studies to confirm these findings in humans. Abstract Written by Dar AlMandumh, 2025, Using AI.

The liver is a vital organ that plays a key role in the detoxification of body endogenous and exogenous substances. These substances can cause hepatic injury. Branched chain amino acids (BCAAs), valine (Val), leucine (Leu) and isoleucine (Ile). Protein of soybean and wheat germ characterized much quantity of BCAAs. This study included chemical analysis and amino acids contents in soybean and wheat germ, ). Results indicated that rats feds on different formulas which contained soybean 5% and wheat germ 5% and its mixtures were gradually significant decrease in serum Aspartate Amino Transferase (AST) ( from 30.20 to 35.80%), Alanine Amino Transferase (ALT) (from 52.50 to 61.06%) and Alkaline phosphatase (ALP) (from 9.90 to 22.03%) compared to positive group

Oxidative stress plays an important role in the development of diabetic complications. Urtica dioica L. has been traditionally used as an herbal remedy for hypoglycemic. The aim of the present study was to evaluate the effect of stinging Nettle Leaves powder (NLP) and its aqueous extract (NLAE) on oxidative stress status of rats with diabetic nephropathy, The results at the end of biological experiment for diabetic rats fed on basal diet supplemented with NLP or NLAE may be helping to maintain an ideal body weight and feed efficiency ratio This study recommended that Urtica dioica L. is suitable for diabetic patients with nephropathy.

This study aimed to evaluate the potential activity of persimmon fruit juice (PFJ) against rheumatoid arthritis (RA). The study conducted on 35 female albino (Sprague-Dawley) rats weighing (170±10g)were randomly divided into five groups(7each) fed on basal diet the first group was the control negative and four other groups were injured with 1ml/kg of Freund's complete adjuvant into the left hind knee joint for 7 days to induce RA. They were re-divided as follows: group 2 served as the control positive group and the three other groups were treated with different doses of PFJ (low)1ml, (high)2ml/kg bw and drugs Diclofenac sodium(DS)10mg/kg bw, respectively. The experiment lasted for 28 days. The chemical results displayed that the persimmon fruit had a high content of fiber, total phenolic, ascorbic acid content and antioxidant activity. While, the biological results revealed that the all treated groups by(low, high doses of PFJ and DS) showed a significant decrease in paw volume as well as improved biochemical and hematological analyses such as white blood cell count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, malondialdehyde, interleukin(IL)-6 and tumors necrosis factor(TNF)- levels. While showed a significant increase in body weight, hemoglobin level, red blood cell count, and antioxidant enzymes in joint tissue. Histological examination of joints tissue confirmed the results of biochemical analyzes of blood. It can be recommended that the necessity consumption of persimmon fruit juice in the diets of peoples exposed to rheumatoid arthritis, because of their anti-rheumatoid arthritis and antioxidants properties, and that play important role of health status.

The objective of this study was to assess the effect of Alpinia officinarum aqueous extract (AOAex) on Lipopolysaccharide (LPS)- induced ALI. 50 adult albino male rats Sprague-Dawley strain weighting (180±10 g) were divided randomly into two groups: First main group 9 rats received a baseline diet served as negative control group. Second main group 41 rats, LPS were injected at a dose of 50 mg/kg into the rats to cause ALI, after that 5 rats from LPS groups were slaughtered to confirm ALI. Then, rats reclassified into 4 equal groups (9 rats each) as following: Group 1 served as the control positive group and 3 treated rat groups were fed basal diets and given oral doses of AOAex (100, 150, and 200 mg/kg) for 28 day. The results revealed that in the all rat groups treated by different levels of AOAex, pro-inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α) and oxidative stress decreased. Also, neutrophil infiltration, lymphocytes, monocytes and IgE level reduced. Correspondingly, hematological parameters (Hb, HCT, RBCs, WBCs) and antioxidant enzymes (SOD, CAT, GSH and GPX) were improved dramatically in serum, lung tissues and bronchoalveolar lavage fluid. Additionally, there were significant improvements in the histological examination of ALI brought on by LPS. It can be recommend that the consumption of Alpinia officinarum aqueous extract (AOAex) have antioxidant and anti-inflammatory effects and that play significant safer role from treatment of acute lung injury and inhibit of inflammatory and complications in rats.