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Hyperostosis frontalis interna is an irregular thickening of the frontal bone. Its etiology is unknown. It has been rarely linked with schizophrenia and head injury. Case Presentation. We describe an unusual case of a 44-year-old female with schizophrenia and hyperostosis frontalis interna having a history of head trauma. At the age of 3 years, she had a head injury that could be classified as mild traumatic brain injury. She presents a family history of schizophrenia. She was admitted for resistant schizophrenic disorder. The cranial computed tomography showed bilateral and asymmetrical hyperostosis of the frontal bone that was more pronounced on the right side. This corresponds to the impact of the trauma with frontal atrophy without any metabolic or endocrinal abnormalities. Conclusion. We surmise that the long-term pathological effects of traumatic brain injury, including hyperostosis frontalis interna, are likely to interact with genetic vulnerability and may lead to schizophrenic disorder.

Context: In March 2020, Morocco announced the first COVID-19 case and implemented preventive measures, including home confinement. Aims: Monitoring the psychological effects and prevalence among high- and middle-school students. Settings and Design: This study is cross-sectional, carried online. Methods and Materials: The survey was conducted by publishing an online questionnaire between May 14, 2020 and June 14, 2020, which included inquiries about socio-demographic data, the conditions of home confinement, activities carried out during confinement, and medical history and sleep patterns. To assess depressive disorder, anxiety disorders, and stress, the survey employed the \"DSRS-c,\" \"SCARED,\" and \"PSS10\" scales, respectively. Statistical Analysis Used: Data were received on Google forms coded by Excel 2010 and analyzed by IBM SPSS Statistics 22. Results: Out of the 689 participants, 73.7% were females; the mean age was 16.08 years (standard deviation 1.48). 94.8% of subjects reported changes in sleep habits, and 41.4% of adolescents had high levels of depressive symptoms, while 50.7% had high levels of anxiety symptoms. Several factors were significantly associated with anxiety and depressive symptoms, including being a girl (P = 0.000), being a high-school student (P = 0.011), economic struggles during the pandemic (P = 0.003), doubting the necessity of home confinement (P = 0.000), spending over 3 hours a day on social networks and video games (P = 0.000), dropping out of remote learning (P = 0.000), having a psychiatric history (P = 0.000), having chronic illnesses in the family (P = 0.002), and changes in sleep habits (P = 0.000). Conclusions: The study found high prevalence of depression, anxiety, and stress symptoms among students during the pandemic, emphasizing the need for mental health awareness and support.

The incidence of neuroleptic malignant syndrome justifies the immediate discontinuation of the drug in question and the reinstitution of therapy with another drug. In the case of resistant schizophrenia treated with clozapine, there are insufficient therapeutic options. We report the case of a young patient followed up for resistant schizophrenia who developed neuroleptic malignant syndrome after 5 years of therapy with clozapine. Clozapine therapy was successfully reinitiated, and the dosage was increased to 300 mg/day over 62 days. In light of this clinical case and a review of the literature, we report the possibility of reintroducing clozapine following an incidence of malignant syndrome in patients with resistant schizophrenia with respect to certain rules; in particular, a slow increase in dose after a reasonable period of time and close monitoring.

Introduction: schizophrenic relapse constitutes a formidable challenge in the realm of psychiatric care, often precipitating a cascade of deteriorating symptoms and functional impairment. Addressing this issue necessitates a comprehensive understanding of the factors that contribute to relapse occurrence. Methods: this cross-sectional study, conducted at the Hospital of Mental Health and Psychiatric Diseases in Oujda, sought to explore the intricate interplay between stress, coping mechanisms, and the incidence of relapse among individuals diagnosed with schizophrenia. Over six months, data were collected from three hundred schizophrenia patients, encompassing demographic, clinical, stress, and coping-related variables. Results: analysis of the findings unveiled compelling associations between stress intensity, coping efficacy, and relapse vulnerability. Notably, heightened stress intensity emerged as a significant predictor of relapse occurrence, surpassing the mere exposure to stressors. Furthermore, inadequate coping strategies were found to significantly elevate the risk of relapse, underscoring the pivotal role of adaptive coping skills in mitigating relapse susceptibility. In addition to these associations, the study revealed intriguing insights into the demographic and clinical characteristics of the patient population. Predominantly male and urban-dwelling, the patients exhibited varying levels of education and employment status. A substantial proportion reported a history of substance abuse and psychiatric family history, indicating potential predisposing factors for relapse vulnerability. These findings underscore the imperative of integrating stress management interventions and fostering adaptive coping mechanisms within schizophrenia treatment paradigms. Early identification and targeted interventions aimed at ameliorating stress reactivity and enhancing coping proficiency. Also, it held promise for the reduction of relapse rates and the increase of long-term outcomes for individuals grappling with schizophrenia. Conclusion: by elucidating the nuanced dynamics of stress and coping in relation to relapse, this study contributes valuable insights to the development of tailored interventions and therapeutic strategies in schizophrenia management.

In March 2020, Morocco announced the first COVID-19 case and implemented preventive measures, including home confinement. Monitoring the psychological effects and prevalence among high- and middle-school students. This study is cross-sectional, carried online. The survey was conducted by publishing an online questionnaire between May 14, 2020 and June 14, 2020, which included inquiries about socio-demographic data, the conditions of home confinement, activities carried out during confinement, and medical history and sleep patterns. To assess depressive disorder, anxiety disorders, and stress, the survey employed the \"DSRS-c,\" \"SCARED,\" and \"PSS10\" scales, respectively. Out of the 689 participants, 73.7% were females; the mean age was 16.08 years (standard deviation 1.48). 94.8% of subjects reported changes in sleep habits, and 41.4% of adolescents had high levels of depressive symptoms, while 50.7% had high levels of anxiety symptoms. Several factors were significantly associated with anxiety and depressive symptoms, including being a girl (P = 0.000), being a high-school student (P = 0.011), economic struggles during the pandemic (P = 0.003), doubting the necessity of home confinement (P = 0.000), spending over 3 hours a day on social networks and video games (P = 0.000), dropping out of remote learning (P = 0.000), having a psychiatric history (P = 0.000), having chronic illnesses in the family (P = 0.002), and changes in sleep habits (P = 0.000). The study found high prevalence of depression, anxiety, and stress symptoms among students during the pandemic, emphasizing the need for mental health awareness and support.

Au Maroc, les tentatives de suicide (TS) demeurent un sujet mal évalué à cause de considérations socioculturelles et l'absence d'approche longitudinale. L'objectif principal était d’évaluer le devenir des suicidants après 5ans au centre universitaire psychiatrique de Fès, les objectifs secondaires étaient l'estimation de la prévalence des TS, préciser les étiologies les plus fréquentes, et établir une corrélation entre les paramètres sociodémographiques, cliniques et évolutifs. Etude prospective à visée transversale et longitudinale, incluant les suicidants vus à l'hôpital psychiatrique de Fès, avec un suivi longitudinal sur 5ans. L’évaluation a été faite par un hétéro-questionnaire et le Mini International Neuropsychiatric Interview (MINI) cherchant le trouble psychiatrique sous jacent. On a recruté 105 patients suicidants, 62% des femmes, l’âge moyen est de 29,23ans. La prévalence des tentatives de suicide est de 3% sur l'ensemble des consultants à l’établissement. Les troubles de l'humeur, psychotiques et de personnalité ont occupé respectivement 37,6%, 27,7%, et 25,7% des cas. La récidive suicidaire a été notée chez 54% des patients, était significativement corrélée à la vie solitaire (P: 0,039) et à la présence d'antécédents familiaux de TS (P: 0,046). L'utilisation de moyens violents était significativement fréquente chez les patients psychotiques. Après 5ans, 32 patients ont répondu à notre appel. Le taux de récidive était de 15%. On a noté trois cas de décès dont deux suicides confirmés. Les résultats confirment les données de la littérature scientifique avec certaines particularités cliniques et évolutives.

chronic haemodialysis patients are a vulnerable population significantly affected by the COVID-19 pandemic, which has had a severe impact on people with co-morbidities and immune system depression, which increases the risk of infection and of developing severe form of COVID-19. The purpose of this study is to assess the impact of the COVID-19 pandemic on the mental health and quality of life of chronic haemodialysis patients. we conducted a descriptive cross-sectional survey among 175 chronic hemodialysis patients using the Mini International Neuropsychiatric Interview Moroccan Arab Version 5.0.0 scale, the Perceived Stress Scale, and the Quality of Life Scale for Chronic Hemodialysis Patients (KDQOL-SFTM 1.3). one hundred and seventy-five (175) participants were recruited, of whom 76 patients had COVID-19. COVID-19 infection was significantly associated with age (p=0.018), psychiatric disorders (p=0.00), a history of suicide attempts (p=0.006) and high-stress levels (p=0.01). The quality of life of chronic haemodialysis patients was significantly impaired in patients with COVID-19 (p=0.00), especially in subjects who were elderly (p=0.034), lived alone (p=0.004), had a history of organic (p=0.04), psychiatric (p=0.00), or substance abuse issues (p=0.003), as well as in patients with a symptomatic form (p=0.001), complications (p=0.00), or hospitalisation secondary to COVID-19 (p=0.00), and those with severe stress (p=0.00). the mental health and quality of life of chronic haemodialysis patients were mainly negatively influenced during the COVID-19 pandemic.

Background. Biobanks are highly organized infrastructures that allow the storage of human biological specimens associated with donors’ personal and clinical data. These infrastructures play a key role in the development of translational medical research. In this context, we launched, in November 2015, the first biobank in Morocco (BRO Biobank) in order to promote biomedical research and provide opportunities to include Moroccan and North African ethnic groups in international biomedical studies. Here, we present the setup and the sample characteristics of BRO Biobank. Methods. Patients were recruited at several departments of two major health-care centers in the city of Oujda. Healthy donors were enrolled during blood donation campaigns all over Eastern Morocco. From each participant, personal, clinical, and biomedical data were collected, and several biospecimens were stored. Standard operating procedures have been established in accordance with international guidelines on human biobanks. Results. Between November 2015 and July 2020, 2446 participants were recruited into the BRO Biobank, of whom 2013 were healthy donors, and 433 were patients. For healthy donors, the median age was 35 years with a range between 18 and 65 years and the consanguinity rate was 28.96%. For patients, the median age was 11 years with a range between 1 day and 83 years. Among these patients, 55% had rare diseases (hemoglobinopathies, intellectual disabilities, disorders of sex differentiation, myopathies, etc.), 13% had lung cancer, 4% suffered from hematological neoplasms, 3% were from the kidney transplantation project, and 25% had unknown diagnoses. The BRO Biobank has collected 5092 biospecimens, including blood, white blood cells, plasma, serum, urine, frozen tissue, FFPE tissue, and nucleic acids. A sample quality control has been implemented and suggested that samples of the BRO Biobank are of high quality and therefore suitable for high-throughput nucleic acid analysis. Conclusions. The BRO Biobank is the largest sample collection in Morocco, and it is ready to provide samples to national and international research projects. Therefore, the BRO Biobank is a valuable resource for advancing translational medical research.