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"FOX, A."
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It still takes a candidate : why women don't run for office
\"It Still Takes a Candidate serves as the only systematic, nationwide empirical account of the manner in which gender affects political ambition\"--Provided by publisher.
Book
The myth of ‘stable’ coronary artery disease
Patients with known cardiovascular disease who have not had a recent acute event are often referred to as having stable coronary artery disease (CAD). The concept of ‘stable’ CAD is misleading for two important reasons: the continuing risks of cardiovascular events over the longer term and the diverse spectrum of powerful risk characteristics. The risks of cardiovascular events are frequently underestimated and continue to exist, despite current standards of care for secondary prevention, including lifestyle changes, optimal medical therapy, myocardial revascularization and the use of antiplatelet agents to limit thrombosis. In dispelling the myth of ‘stable’ CAD, we explore the pathophysiology of the disease and the relative contribution of plaque and systemic factors to cardiovascular events. A broader concept of the vulnerable patient, not just the vulnerable plaque, takes into account the diversity and future risks of atherothrombotic events. We also evaluate new and ongoing research into medical therapies aimed at further reducing the risks of cardiovascular events in patients with chronic — but not stable — atherothrombotic disease.
Journal Article
صور جيدة وصور سيئة : تفسير الإباحية لأطفال اليوم
قبل عشرة أعوام من البدء في مشروع هذا الكتاب، توفي ابني الصغير وبعد بضعة أشهر من موته، أحضرت لي \"ديبي فوكس\" لوحة جميلة له بالألوان المائية، كانت قد رسمتها من صورته في حفل التأبين. واعتبرت هذه الهدية أحد أكثر الأشياء العزيزة على قلبي.وعندما سألت نفسي : \"كيف نختار صورا إيضاحية لكتاب موجه للأطفال يتحدث عن المواد الإباحية ؟\" كنت أعرف أنني أريد أن تكون الرسوم الإيضاحية بالألوان المائية ؛ وأنها ينبغي أن تكون كلاسيكية ولطيفة لتخفف من قسوة الموضوع؛ وأن تكون حقيقية وليست كاريكاتورية-لم أكن أريد أن أخاطر بالتقليل من هذه المشكلة الخطيرة.وكان من الطبيعي أن نختار ديبي لتصمم الرسوم الإيضاحية الواقعية والجميلة التي نحتاج إليها، وأنا ممتنة لقبولها التحدي. كانت تحلم بالعمل معنا، وقد أظهرت صبرا ومرونة لا حدود لهما. نحن نؤمن بأن رسوماتها جعلت الكتاب أكثر راحة وجاذبية للآباء والأمهات والأطفال.
Book
Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease
Advances in antiplatelet therapies for patients with cardiovascular disease have improved patient outcomes over time, but the challenge of balancing the risks of ischaemia and bleeding remains substantial. Moreover, many patients with cardiovascular disease have a residual risk of ischaemic events despite receiving antiplatelet therapy. Therefore, novel strategies are needed to prevent clinical events through mechanisms beyond platelet inhibition and with an acceptable associated risk of bleeding. The advent of non-vitamin K antagonist oral anticoagulants, which attenuate fibrin formation by selective inhibition of factor Xa or thrombin, has renewed the interest in dual-pathway inhibition strategies that combine an antiplatelet agent with an anticoagulant drug. In this Review, we highlight the emerging pharmacological rationale and clinical development of dual-pathway inhibition strategies for the prevention of atherothrombotic events in patients with different manifestations of cardiovascular disease, such as coronary artery disease, cerebrovascular disease and peripheral artery disease.Many patients with cardiovascular disease have a residual risk of ischaemic events despite receiving antiplatelet therapy. In this Review, Angiolillo and colleagues discuss the pharmacological rationale and clinical development of dual-pathway inhibition strategies for the prevention of atherothrombotic events in patients with cardiovascular disease.
Journal Article
بيت جديد للثعلب الصغير
تتناول قصة (بيت جديد للثعلب الصغير) والتي قامت بتأليفها جانيت بينغهام ؛ ترجمة هيئة التحرير في أكاديميا ؛ رسوم روزاليد بيردشو. في حوالي (28) صفحة من القطع المتوسط، وهي من مجموعة قصصية للأطفال وتتناول بأسلوب شيق وسهل، القصة عن ثعلب صغير يعلم كل شيء عن بيوت أصدقائه الذين يعيشون في الغابة ولكن، أين سيبني مع والده بيتهما الجديد ؟.
BOOK
The Magellanic Corona as the key to the formation of the Magellanic Stream
The dominant gaseous structure in the Galactic halo is the Magellanic Stream. This extended network of neutral and ionized filaments surrounds the Large Magellanic Cloud (LMC) and the Small Magellanic Cloud (SMC), the two most massive satellite galaxies of the Milky Way
1
–
4
. Recent observations indicate that the LMC and SMC are on their first passage around the Galaxy
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, that the Magellanic Stream is made up of gas stripped from both clouds
2
,
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,
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and that the majority of this gas is ionized
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,
9
. Although it has long been suspected that tidal forces
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,
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and ram-pressure stripping
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,
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contributed to the formation of the Magellanic Stream, models have not been able to provide a full understanding of its origins
3
. Several recent developments—including the discovery of dwarf galaxies associated with the Magellanic group
14
–
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, determination of the high mass of the LMC
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, detection of highly ionized gas near stars in the LMC
18
,
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and predictions of cosmological simulations
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,
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—support the existence of a halo of warm (roughly 500,000 kelvin) ionized gas around the LMC (the ‘Magellanic Corona’). Here we report that, by including this Magellanic Corona in hydrodynamic simulations of the Magellanic Clouds falling onto the Milky Way, we can reproduce the Magellanic Stream and its leading arm. Our simulations explain the filamentary structure, spatial extent, radial-velocity gradient and total ionized-gas mass of the Magellanic Stream. We predict that the Magellanic Corona will be unambiguously observable via high-ionization absorption lines in the ultraviolet spectra of background quasars lying near the LMC.
Embedding the Magellanic Clouds in a corona of ionized gas allows the gaseous Magellanic Stream to be modelled accurately.
Journal Article
The complete insect : anatomy, physiology, evolution, and ecology
A beautifully illustrated exploration of the world's most extraordinary animalsWith an astounding 3.5 million species occupying virtually every habitat on Earth, insects are one of the most diverse groups of animals on the planet, from the humble bee to the agile praying mantis. Taking you inside the extraordinary world of insects, The Complete Insect explores all aspects of the natural history of these remarkable creatures, providing a close-up look at their fascinating anatomy, physiology, evolution, ecology, behavior, and more. It features hundreds of stunning color photographs and illustrations and draws on a broad range of examples, from familiar ants to iridescent jewel beetles. A celebration of the rich complexity of insect life, The Complete Insect is a must-have book for insect enthusiasts and armchair naturalists.An absorbing, wide-ranging, and beautiful exploration of the fascinating natural history of insectsFeatures a wealth of stunning full-color photographs from the fieldIncludes photomicrographs and electron micrographs that offer a rare view of normally invisible structuresExamines the complex relationship between humans and insectsIntegrates physiological adaptations with ecology and behavior.
Book
Bright single photon emitters with enhanced quantum efficiency in a two-dimensional semiconductor coupled with dielectric nano-antennas
Single photon emitters in atomically-thin semiconductors can be deterministically positioned using strain induced by underlying nano-structures. Here, we couple monolayer WSe
2
to high-refractive-index gallium phosphide dielectric nano-antennas providing both optical enhancement and monolayer deformation. For single photon emitters formed on such nano-antennas, we find very low (femto-Joule) saturation pulse energies and up to 10
4
times brighter photoluminescence than in WSe
2
placed on low-refractive-index SiO
2
pillars. We show that the key to these observations is the increase on average by a factor of 5 of the quantum efficiency of the emitters coupled to the nano-antennas. This further allows us to gain new insights into their photoluminescence dynamics, revealing the roles of the dark exciton reservoir and Auger processes. We also find that the coherence time of such emitters is limited by intrinsic dephasing processes. Our work establishes dielectric nano-antennas as a platform for high-efficiency quantum light generation in monolayer semiconductors.
Single photon emitters (SPEs) in 2D semiconductors can be deterministically positioned using localized strain induced by underlying nanostructures. Here, the authors show SPE coupling in WSe
2
to GaP dielectric nanoantennas, substantially increasing quantum efficiency and photoluminescence brightness.
Journal Article
كيف تروض ثعلبا وتصنع كلبا : علماء حالمون وحكاية سيبيرية عن التطور السريع
هي قصة، جزء منها حول العلم، وجزء منها تبدو كقصة خيالية روسية، وجزء منها أشبه بفلم تجسس وغموض، في هذا الكتاب، يقوم كل من دوغتاكن وتروت بسرد حكاية هذه التجربة العظيمة، والنتجية مجموعة من الثعالب الأليفة وتحديد الأسس الوراثية لتدجينها و\"لقد قاموا بتجربتهم في مزرعة في سيبيريا، وخلال عقود عديدة قاموا بتزوية أكثر الثعالب ألفة في جيلها\".
BOOK
Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
In this trial, 14,264 patients with atrial fibrillation were randomly assigned to receive either rivaroxaban or warfarin. In a per-protocol, as-treated analysis, rivaroxaban was noninferior to warfarin with respect to the primary end point of stroke or systemic embolism.
Atrial fibrillation is associated with an increase in the risk of ischemic stroke by a factor of four to five
1
and accounts for up to 15% of strokes in persons of all ages and 30% in persons over the age of 80 years.
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The use of vitamin K antagonists is highly effective for stroke prevention in patients with nonvalvular atrial fibrillation and is recommended for persons at increased risk.
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–
5
However, food and drug interactions necessitate frequent coagulation monitoring and dose adjustments, requirements that make it difficult for many patients to use such drugs in clinical practice.
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–
8
Rivaroxaban is . . .
Journal Article