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Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
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Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
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Journal Article
Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
2011
Overview
In this trial, 14,264 patients with atrial fibrillation were randomly assigned to receive either rivaroxaban or warfarin. In a per-protocol, as-treated analysis, rivaroxaban was noninferior to warfarin with respect to the primary end point of stroke or systemic embolism.
Atrial fibrillation is associated with an increase in the risk of ischemic stroke by a factor of four to five
1
and accounts for up to 15% of strokes in persons of all ages and 30% in persons over the age of 80 years.
2
The use of vitamin K antagonists is highly effective for stroke prevention in patients with nonvalvular atrial fibrillation and is recommended for persons at increased risk.
3
–
5
However, food and drug interactions necessitate frequent coagulation monitoring and dose adjustments, requirements that make it difficult for many patients to use such drugs in clinical practice.
6
–
8
Rivaroxaban is . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Anticoagulants - adverse effects
/ Anticoagulants - therapeutic use
/ Atrial Fibrillation - complications
/ Atrial Fibrillation - drug therapy
/ Biological and medical sciences
/ Bleeding
/ Embolism
/ Embolism - prevention & control
/ Equity
/ Female
/ Heart
/ Hemorrhage - chemically induced
/ Humans
/ Ischemia
/ Male
/ Morpholines - administration & dosage
/ Morpholines - adverse effects
/ Morpholines - therapeutic use
/ R&D
/ Stroke
/ Stroke - prevention & control
/ Thiophenes - administration & dosage
/ Thiophenes - adverse effects
/ Thiophenes - therapeutic use
/ Warfarin
