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Precise timing synchronization remains a fundamental requirement for modern navigation and communication systems, where the miniaturization of Loran-C infrastructure presents both technical challenges and practical significance. Conventional miniaturized loop antennas cannot simultaneously meet the requirements of the Loran-C signal for both radiation intensity and bandwidth due to inherent quality factor (Q) limitations. A sub-cubic-meter impedance matching (IM) antenna is proposed, featuring a −20 dB bandwidth of 18 kHz and over 7-fold radiation enhancement. The proposed design leverages a planar-transformer-based impedance matching network to enable efficient 100 kHz operation in a compact form factor, while a resonant coil structure is adopted at the receiver side to enhance the system’s sensitivity. The miniaturized Loran-C timing system incorporating the IM antenna achieves an extended decoding range of >100 m with merely 100 W input power, exceeding conventional loop antennas limited to 30 m operation. This design successfully achieves overall miniaturization of the Loran-C timing system while breaking through the current transmission distance limitations of compact antennas, extending the effective transmission range to the hundred-meter scale. The design provides a case for developing compact yet high-performance Loran-C systems.

Background Hypertension has become an important health risk factor in the twenty-first century, especially for the elderly. Studies have confirmed that inflammation is involved in the development of hypertension and that the inflammatory marker C-reactive protein(CRP) is significantly associated with hypertension. Therefore, in this study, we aimed to explore the CRP correlation with hypertension in the elderly. Methods Serum CRP levels were measured in 196 hospitalized patients, and the CRP level was used as a criterion to divide them into the group with elevated CRP (> 10 mmol/L, n  = 120) and the group with normal CRP (0 < CRP ≤ 10 mmol/L, n  = 76). and the patient's baseline characteristics were collected and compared between the groups, and the correlation between CRP and other factors and hypertension in the elderly was analyzed by multi-factor logistic regression. Results The prevalence of hypertension, coronary artery disease and joint reactive inflammation was significantly higher in the group with elevated CRP. There was also a significant association between the use of alcohol, low density lipoprotein cholesterol (LDL-C) and steroids and elevated CRP; logistic regression showed that elevated CRP (OR = 2.13, 95% CI: 1.14–3.99, p  = 0.019), body mass index (BMI) (OR = 1.10, 95% CI:1.01–1.90, p  = 0.030), diabetes (OR = 2.68, 95% CI:1.24–5.79, p  = 0.012) were positively associated with hypertension, while statins use was negatively associated with hypertension (OR = 0.49, 95% CI: 0.25–0.94, p  = 0.013). Conclusions Elevated CRP, BMI, and diabetes are positively associated with hypertension in the elderly, and early screening for CRP and initiation of treatment may help prevent further inflammatory responses in hypertension. Highlights 1. Inflammation plays an important role in vascular remodeling and myocardial remodeling in hypertension. Our study found that CRP, as a marker of systemic inflammation, was significantly positively correlated with hypertension in the elderly. 2. The most common phenomenon in elderly patients is co-morbidity. we found that the proportion of hypertension, coronary heart disease and arthritis in patients with elevated CRP was significantly higher than that in patients with normal CRP. 3. Inflammation is related to hypertension, and CRP is one of the inflammatory markers. Early screening and intervention of CRP may delay the progression of hypertension.

Introduction Oxidative stress caused by elevated ROS, as a novel therapeutic mechanism, has been implicated in various tumors including AML. AML cells are chronically under oxidative stress, yet overreliance on ROS production makes tumor cells increasingly vulnerable to further damage. Reducing the cytotoxic effect of ROS on normal cells while killing leukemia stem cell (LSC) with high levels of reactive oxygen species is a new challenge for oxidative stress therapy in leukemia. Methods By searching literature databases, we summarized recent relevant studies. The relationship of ROS on AML genes, signaling pathways, and transcription factors, and the correlation of ROS with AML bone marrow microenvironment and autophagy were summarized. In addition, we summarize the current status of research on ROS and AML therapeutics. Finally, we discuss the research progress on redox resistance in AML. Results This review discusses the evidence showing the link between redox reactions and the progression of AML and compiles the latest research findings that will facilitate future biological studies of redox effects associated with AML treatment. Conclusion We believe that exploiting this unique oxidative stress property of AML cells may provide a new way to prevent relapse and drug resistance.

This study investigates the dynamic response characteristics of aluminum foam materials under low to medium-high velocity impact loading, elucidating their deformation mechanisms and energy absorption capabilities through an integrated experimental and numerical simulation approach. The multi-stage deformation behavior of aluminum foam was investigated through the Taylor impact test, which demonstrated that impact velocity significantly affects its stiffness and energy absorption capability. The accuracy of stress distribution and mechanical properties during the impact process is validated, and the deformation behavior under medium- and high-speed impact conditions is clearly revealed. Through integrated macroscopic and microscopic analyses, the dynamic response characteristics of aluminum foam under various impact loads are systematically investigated, elucidating the mechanisms of internal pore collapse and dynamic compressive behavior, thereby providing robust theoretical support for the optimized design of aluminum foam in cushioning and protective applications.

To understand the effects of temperature and shock loading environments on the response characteristics of typical fuzes, temperature loading and combined temperature-impact loading tests were carried out to study the influence of environmental load on typical fuzes. The damage characteristics of the detonator under the coupling of temperature and temperature-impact load were analyzed by SEM, and the response characteristics of the fuze under different loading conditions were studied. The results show that the single high and low temperature storage and drop environments do not have a significant effect on the fuze casing; the temperature-overload coupling loading test intensifies the reaction degree of insensitive fuzes in the slow cook-off test, and the influence of low temperature environment is the most significant.

Viscoplastic work is very important to explosive ignition under impact loading. At present, a large number of constitutive models only consider the viscoelastic and damage behavior of explosives, ignoring the plastic effect under low impact loading. A new viscoelastic–viscoplastic (VE–VP) model was developed and studied to describe the dynamic mechanical behaviors of polymer-bonded explosives (PBXs). The total strain was assumed to be the sum of the viscoelastic (VE) and viscoplastic (VP) components. A generalized Maxwell model was used to determine the VE responses. A VP model was developed by using the classical J 2 rate-dependent model with isotropic hardening. Viscoplastic flow was considered in hyperbolic sinusoidal form. The explicit algorithms of VE model were proposed and assessed by using two different integration methods. The accuracy and efficiency of these two methods are similar at high strain rates. The coupled algorithms of VE–VP model were developed by referring to the classical elasto-viscoplasticity (EVP) provided and using the expression of incremental relaxation modulus. The proposed model was implemented in the ABAQUS using a user-subroutine (VUMAT) to predict the response behaviors of PBX 9501 under low impact loading. Several numerical simulations illustrated the computational efficiency and the accuracy of the proposed methods. The model predictions were compared with experimental data, and reasonable agreement was obtained.

A new visco-hyperelastic constitutive model is developed to describe the dynamic compressive behavior of polymer-bonded explosive (60 wt% RDX, 16 wt% aluminum, and 24 wt% HTPB) and its polymer binder. The constitutive relationship comprises two parts: a component with a strain-energy function to characterize large deformation and a viscoelastic model to describe dynamic viscoelastic behavior. The hyperelastic model parameters are curve-fitted using quasi-static compressive test data under a strain rate of 0.0001 s - 1 . The time–temperature superposition principle master modulus curves are studied using relaxation tests at different temperatures, and their compressive relaxation time and modules are obtained by fitting the master modulus curves. To obtain the rational dynamic compressive results, a modified split-Hopkinson compressive bar setup is designed such that the specimens are in dynamic stress equilibrium and deformed homogeneously at nearly constant strain rates. A comparison of the constitutive relationship with the experimental results revealed a good agreement and demonstrates its potential to describe the dynamic mechanical behavior of the PBX and its polymer binder.

Given the adverse impact of deep vein thrombosis (DVT) on the prognosis of multiple myeloma (MM) patients, identifying biomarkers for DVT is crucial for improving MM patient clinical outcomes. Therefore, this study aimed to evaluate the predictive value of miR-503-5p for DVT in MM, and explored the underlying mechanisms. Serum samples were collected from MM patients with and without DVT to measure miR-503-5p expression levels. ROC and Kaplan-Meier curves were employed to examine the predictive potential of miR-503-5p in MM-related DVT. MM serum-cultured human umbilical vein endothelial cells (HUVECs) were used to investigate the mechanisms of miR-503-5p in influencing the disease. Cell viability, oxidative stress status, and IL-6, TNF-α, TF, and TM levels were evaluated by CCK-8, antioxidant activity assay, and qRT-PCR. MiR-503-5p was upregulated in MM patients with DVT. The upregulation of miR-503-5p was a risk factor that demonstrated a high predictive value for DVT in MM patients. MiR-503-5p upregulation mediated the promotive effect of MM serum on HUVEC viability reduction, IL-6, TNF-α, and TF expression, and oxidative stress, and the inhibitory effect of MM serum on HUVEC TM expression. Moreover, WNT3A was a potential target of miR-503-5p in MM-related DVT. WNT3A downregulation mediated the effect of miR-503-5p on HUVECs. MiR-503-5p might be a promising biomarker for predicting DVT development in MM patients. MiR-503-5p might promote thrombosis in MM by affecting vein endothelial cells (VECs) through targeting WNT3A.

Perovskite quantum dots (PQDs) based on CsPbX3 (X = Cl, Br, I) have attracted extensive attention due to their outstanding optoelectronic properties; however, their practical applications are hindered by poor environmental stability. In this work, a sequential surface-modification strategy is developed to address these limitations. First, CsPbBr3 PQDs are passivated with (3-aminopropyl) triethoxysilane (APTES), which reduces surface defects and enhances the photoluminescence quantum yield (PLQY) from 38.5% to 74.4%. Subsequently, a dense silica shell is constructed via in situ hydrolysis of tetramethyl orthosilicate (TMOS), further improving the PLQY to 95.6% and significantly boosting environmental stability. Structural and optical characterizations confirm effective defect passivation and suppress non-radiative recombination, with carrier lifetimes extended from 2.5 ns to 36.9 ns. Remarkably, the silica-coated PQDs retain over 50% of their initial emission intensity after 100 min of water immersion, far exceeding the stability of uncoated counterparts. Furthermore, when integrated with a commercial K2SiF6: Mn4+ red phosphor and a blue light-emitting diode (LED) chip, the resulting white LED (WLED) exhibits a wide color gamut covering 104% of the National Television System Committee (NTSC) standard and Commission Internationale de l’Éclairage (CIE) coordinates of (0.323, 0.331), closely matching standard white light. Importantly, only the silica-coated PQDs maintain a stable electrically driven device emission spectrum after water exposure.