Journal Article

The relationship between serum C-reactive protein and senile hypertension

Li, Gang, He, Le, Fan, Chenyang

2022

Overview

Background Hypertension has become an important health risk factor in the twenty-first century, especially for the elderly. Studies have confirmed that inflammation is involved in the development of hypertension and that the inflammatory marker C-reactive protein(CRP) is significantly associated with hypertension. Therefore, in this study, we aimed to explore the CRP correlation with hypertension in the elderly. Methods Serum CRP levels were measured in 196 hospitalized patients, and the CRP level was used as a criterion to divide them into the group with elevated CRP (> 10 mmol/L, n  = 120) and the group with normal CRP (0 < CRP ≤ 10 mmol/L, n  = 76). and the patient's baseline characteristics were collected and compared between the groups, and the correlation between CRP and other factors and hypertension in the elderly was analyzed by multi-factor logistic regression. Results The prevalence of hypertension, coronary artery disease and joint reactive inflammation was significantly higher in the group with elevated CRP. There was also a significant association between the use of alcohol, low density lipoprotein cholesterol (LDL-C) and steroids and elevated CRP; logistic regression showed that elevated CRP (OR = 2.13, 95% CI: 1.14–3.99, p  = 0.019), body mass index (BMI) (OR = 1.10, 95% CI:1.01–1.90, p  = 0.030), diabetes (OR = 2.68, 95% CI:1.24–5.79, p  = 0.012) were positively associated with hypertension, while statins use was negatively associated with hypertension (OR = 0.49, 95% CI: 0.25–0.94, p  = 0.013). Conclusions Elevated CRP, BMI, and diabetes are positively associated with hypertension in the elderly, and early screening for CRP and initiation of treatment may help prevent further inflammatory responses in hypertension. Highlights 1. Inflammation plays an important role in vascular remodeling and myocardial remodeling in hypertension. Our study found that CRP, as a marker of systemic inflammation, was significantly positively correlated with hypertension in the elderly. 2. The most common phenomenon in elderly patients is co-morbidity. we found that the proportion of hypertension, coronary heart disease and arthritis in patients with elevated CRP was significantly higher than that in patients with normal CRP. 3. Inflammation is related to hypertension, and CRP is one of the inflammatory markers. Early screening and intervention of CRP may delay the progression of hypertension.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Age / Aged patients / Angiology / Anti-inflammatory agents / Antihypertensives / Arthritis / Asthma / Blood pressure / Blood Transfusion Medicine / Body mass index / C-reactive protein / Cardiac Surgery / Cardiology / Cardiovascular disease / Care and treatment / Cerebrovascular disease / Cholesterol / Cholesterol, LDL / Chronic obstructive pulmonary disease / Complications and side effects / Confounding (Statistics) / Coronary artery disease / Development and progression / Diabetes / Diabetes mellitus / Distribution / Drugs / Elderly / Geriatrics / Health aspects / Heart diseases / Heart failure / High density lipoprotein / Hypertension / Hypothyroidism / Inflammation / Internal Medicine / Laboratories / Liver diseases / Low density lipoprotein / Measurement / Medicine / Medicine & Public Health / Mortality / Older people / Regression analysis / Risk factors / Statins / Steroid hormones / Womens health