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Coronavirus disease 2019 (COVID-19) pandemic is a major public health concern all over the world. Little is known about the impact of COVID-19 pandemic on mental health in the general population. This study aimed to assess the mental health problems and associated factors among a large sample of college students during the COVID-19 outbreak in China. This cross-sectional and nation-wide survey of college students was conducted in China from 3 to 10 February 2020. A self-administered questionnaire was used to assess psychosocial factors, COVID-19 epidemic related factors and mental health problems. Acute stress, depressive and anxiety symptoms were measured by the Chinese versions of the impact of event scale-6, Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7, respectively. Univariate and hierarchical logistic regression analyses were performed to examine factors associated with mental health problems. Among 821 218 students who participated in the survey, 746 217 (90.9%) were included for the analysis. In total, 414 604 (55.6%) of the students were female. About 45% of the participants had mental health problems. The prevalence rates of probable acute stress, depressive and anxiety symptoms were 34.9%, 21.1% and 11.0%, respectively. COVID-19 epidemic factors that were associated with increased risk of mental health problems were having relatives or friends being infected (adjusted odds ratio = 1.72-2.33). Students with exposure to media coverage of the COVID-19 ≥3 h/day were 2.13 times more likely than students with media exposure <1 h/day to have acute stress symptoms. Individuals with low perceived social support were 4.84-5.98 times more likely than individuals with high perceived social support to have anxiety and depressive symptoms. In addition, senior year and prior mental health problems were also significantly associated with anxiety or/and depressive symptoms. In this large-scale survey of college students in China, acute stress, anxiety and depressive symptoms are prevalent during the COVID-19 pandemic. Multiple epidemic and psychosocial factors, such as family members being infected, massive media exposure, low social support, senior year and prior mental health problems were associated with increased risk of mental health problems. Psychosocial support and mental health services should be provided to those students at risk.

This study examines the patterns and predictors of post-traumatic stress disorder (PTSD) symptom trajectories among adolescent survivors following the Wenchuan earthquake in China. A total of 1573 adolescent survivors were followed up at 6, 12, 18 and 24 months post-earthquake. Participants completed the Posttraumatic Stress Disorder Self-Rating Scale (PTSD-SS), Adolescent Self-Rating Life Events Checklist, Social Support Rate Scale, and the Simplified Coping Style Questionnaire. Distinct patterns of PTSD symptom trajectories were established through grouping participants based on time-varying changes of developing PTSD (i.e. reaching the clinical cut-off on the PTSD-SS). Multivariate logistic regressions were used to examine predictors for trajectory membership. PTSD prevalence rates at 6, 12, 18 and 24 months were 21.0, 23.3, 13.5 and 14.7%, respectively. Five PTSD symptom trajectories were observed: resistance (65.3% of the sample), recovery (20.0%), relapsing/remitting (3.3%), delayed dysfunction (4.2%) and chronic dysfunction (7.2%). Female gender and senior grade were related to higher risk of developing PTSD symptoms in at least one time point, whereas being an only child increased the possibility of recovery relative to chronic dysfunction. Family members' injury/loss and witness of traumatic scenes could also cause PTSD chronicity. More negative life events, less social support, more negative coping and less positive coping were also common predictors for not developing resistance or recovery. Adolescents' PTSD symptoms showed an anniversary reaction. Although many adolescents remain euthymic or recover over time, some adolescents, especially those with the risk factors noted above, exhibit chronic, delayed or relapsing symptoms. Thus, the need for individualized intervention with these adolescents is indicated.

Purpose This study aims to explore how the local tour guides (LTGs) operate through the sharing economy platform. This study explores how LTGs have responded to the COVID-19 pandemic restrictions using self-efficacy and other resources to improve resilience and performance. This study also delineates the working mechanisms of peer-to-peer (P2P) platform-enabled, dynamic capability building processes, in the tourism sharing economy. Design/methodology/approach This research adopted an interpretive approach to understand the focal phenomenon using two types of data. A total of 40 semi-structured interviews with LTGs and 26,478 online tourist reviews from tour guide service participants’ before and during the COVID-19 pandemic were used. Findings The findings of this study revealed that LTGs used sharing economy platforms to arrange flexible tour guide services. Resilience emerged through dynamic capability that addressed contextual factors in real time. LTGs coordinated different resources and customers during a time of uncertainty. Different sources of self-efficacy and types of dynamic capability were identified. The interplay between LTGs’ self-efficacy and dynamic capability was also delineated. Practical implications The findings provide guidance for LTGs on P2P platforms and other sharing economy sectors on how diverse resources enabled by the sharing economy can enhance resilience during times of uncertainty. LTGs that engage with contextual information and are dynamic can adopt itineraries and services that will benefit tourists and their business. Originality/value This study contributes to the sharing economy literature by theorizing the working flow that enables LTGs to exert self-efficacy and leverage dynamic capability on P2P platforms. This study also contributes by linking resilience to contextual factors in real time. The outcomes provide guidance for LTGs to remain competitive and establish resilience in uncertain environments.

Purpose This research paper aims to explore whether and how perceived corporate social responsibility (CSR) influences employee-associated outcomes in ways that are controllable by managers. Drawing from the theories of self-determination and social identity, this study investigates the mediating effects of psychological needs fulfillment and organizational identification in exploring the mechanisms that link perceived CSR to employee job performances of Chinese state-owned tourism companies. Design/methodology/approach Survey was used to collect original data from ten Chinese state-owned tourism companies to examine the proposed model. Data was analyzed through structural equation modeling. Findings Employees’ perceptions of CSR are found to demonstrate significantly effective associations with their job performance. Moreover, results support that the influences of CSR on staff’s job performance are also conveyed through psychological needs fulfillment (competence) and organizational identification (i.e. cognitive identification and affective identification). Practical implications Findings not only provide strategic ideas and operational tactics for tourism managers to devise CSR strategies and allocate CSR resources but also offer inspirations to integrate CSR initiatives with human resource management strategies. Originality/value This study diverts the research of CSR from the organizational level to the individual level. This study also explores the mechanism of psychological needs fulfillment and organizational identification underlying processes in the employee perceptions of CSR–job performance linkages.

The increase in atmospheric CO2 concentration elevates atmospheric temperature and enhances water storage capacity. This could lead to more extreme precipitation events, while simultaneously, higher temperatures may cause land and soil to dry out. Such alterations create ambiguous expectations regarding the direction of hydrological changes in the following decades. This work quantifies streamflow changes on flood discharges in South America based on the MGB‐SA hydrodynamic‐hydrological model forced with the Climate Model Intercomparison Project (CMIP6) ensemble of climate projections. Future projections indicate that floods are expected to increase in magnitude and become up to five times more frequent in Southern Brazil, a region recently impacted by unprecedented flooding. In contrast, ecosystems such as the Amazon and the Pantanal will likely experience less frequent floods in the coming decades. These projections have relevant implications not only for flood risk in populated areas but also for ecological dynamics. Plain Language Summary Global warming is a phenomenon that is increasing the planet's temperature. This increase leads to more water retained in the atmosphere, potentially increasing precipitation. However, the temperature rise might also increase the evapotranspiration of water in the soil. All these alterations in the water cycle affect river flows and floods. In this work, we quantified the alterations for South America's large rivers using climate projections from CMIP6 and the hydrological model MGB‐SA. Rainfall projections show an increase of 20% in 5 years return period (RP) rainfall and up to 60 % in 100 years RP rainfall. In the following decades, floods might be up to five times more frequent in Southern Brazil, a region recently affected by unprecedented floods. In contrast, the Amazon and Pantanal basins show projections of less frequent floods, which might negatively affect its ecosystem. Key Points CMIP6 projects a rise in maximum daily rainfall across most of South America, though flood flows will not uniformly increase Projections show flood intensification over Southern Brazil, a region recently affected by disastrous floods Amazon, Pantanal, and Bananal wetlands may have decreased flood events, negatively impacting ecosystems

The overall dynamic mechanical behavior of a double-scale discontinuous rock mass with a nonlinear deformational macrojoint was investigated. A method of combining the split three characteristic lines with the piecewise linear displacement discontinuity model (DDM) was proposed. The method was applied to investigate the transmission coefficient of P-wave propagation normally through a double-scale discontinuous rock mass with a nonlinear deformational macrojoint. The results were verified by comparison with the results of P-wave propagation normally through a double-scale discontinuous rock mass with a linear deformational macrojoint. The results showed that for a small amplitude stress wave, the nonlinear deformational macrojoint can be simplified as a linear deformational form to study the stress wave propagation, whereas for a large amplitude stress wave, the effects of the nonlinear deformational behavior of the macrojoint must be considered. The difference of the effects of nonlinear and linear deformational macrojoints on large amplitude stress wave propagation can be overlooked in the low-frequency or high-frequency regions. In addition, when the incident stress wave amplitude and initial macrojoint stiffness are sufficiently large, the effects of the nonlinear deformational macrojoint on stress wave propagation can be overlooked, and the effects of microdefects must be considered. The influence degree of microdefects on the stress wave propagation increases with the increase of incident stress wave frequency.

Despite therapeutic advances, multiple myeloma (MM) remains an incurable disease, predominantly because of the development of drug resistance. The activator protein-1 (AP-1) transcription factor family has been implicated in a multitude of physiologic processes and tumorigenesis; however, its role in MM is largely unknown. Here we demonstrate specific and rapid induction of the AP-1 family member JunB in MM cells when co-cultured with bone marrow stromal cells. Supporting a functional key role of JunB in MM pathogenesis, knockdown of JUNB significantly inhibited in vitro MM cell proliferation and survival. Consistently, induced silencing of JUNB markedly decreased tumor growth in a murine MM model of the microenvironment. Subsequent gene expression profiling revealed a role for genes associated with apoptosis, DNA replication and metabolism in driving the JunB-mediated phenotype in MM cells. Importantly, knockdown of JUNB restored the response to dexamethasone in dexamethasone-resistant MM cells. Moreover, 4-hydroxytamoxifen-induced activation of a JunB-ER fusion protein protected dexamethasone-sensitive MM cells against dexamethasone- and bortezomib-induced cytotoxicity. In summary, our results demonstrate for the first time a specific role for AP-1/JunB in MM cell proliferation, survival and drug resistance, thereby strongly supporting that this transcription factor is a promising new therapeutic target in MM.

Purpose This paper aims to consider whether developing countries can create viable and sustainable tourism sectors. Design/methodology/approach To provide a focus and context to answer the question, the introduction to the subject reviews some of the earlier publication relating to tourism in the developing countries beginning from 1950 and notes how many of these publications foresaw the benefits of using tourism as a supportive activity for general development but also indicated many of the challenges and disadvantages the countries faced in so doing. Findings Looking to 2050, the paper makes two assumptions. First, the demand for international tourism will continue. Second, any future disruption of demand caused by wars, terrorism, epidemics or economic difficulties will be short-term and not as universally disruptive to international travel demand as was caused by Covid-19. The paper concludes that developing countries can create viable tourism sectors but that sustainability is unlikely in the absence of careful and sensitive management of the tourism sector. Practical implications Tourism development options must be evaluated within the potential and capacities of the individual country. There is no single development model. An important initiative is to help identify and develop local talent for the tourism sector, particularly related to planning, policy and implementation requirements. Government and the private sector should be encouraged to cooperate in development initiatives. Originality/value This paper provides an “insider view” of the realities of pursuing sustainable tourism development options and the related challenges and opportunities and emphasises the role of government in this process. 发展中国家可行和可持续的旅游业：2050 年展望视角 摘要 目的 本文的目的是考虑发展中国家是否能够创造可行和可持续的旅游业。 设计/方法 为了提供一个焦点和背景来回答这个问题, 本文的引言回顾了从1950年开始的一些关于发展中国家旅游业的早期文献, 并指出其中有多少文献预见到了旅游业作为支持总体发展活动的优势, 但也指出了各国在这样做时面临的许多挑战和劣势。 研究结果 展望2050 年, 本文做出了两个假设。首先, 对国际旅游业的需求将继续, 其次, 战争、恐怖主义、流行病和经济困难对未来需求的任何破坏都将是短期的, 不会像新冠肺炎对国际旅游需求造成的普遍破坏。文章的结论是, 发展中国家可以创建可行的旅游部门, 但如果不对旅游部门进行谨慎和敏感的管理, 可持续性就不太可能实现。 独创性 本文对追求可持续旅游发展选择的现实以及相关的挑战和机遇提供了“内部视角”, 并强调了政府在这一过程中的作用。 实践影响 旅游业发展方案必须在单个国家的潜力和能力范围内进行评估。没有单一的发展模式。一项重要举措是帮助确定和培养旅游业的当地人才, 特别是与规划、政策和实施要求相关的人才。应鼓励政府和私营部门在发展倡议方面进行合作。 Turismo rentable y sostenible Para los países en desarrollo: Un documento de horizonte 2050 Resumen Objetivo El objetivo de este artículo es estudiar si los países en desarrollo pueden crear sectores turísticos que sean viables y sostenibles. Diseño/metodología Con el fin de aportar un enfoque y contextualización para responder la cuestión, en la introducción al tema se examinan publicaciones previas sobre el turismo en los países en desarrollo a partir de 1950 y se apunta cómo gran parte de estas publicaciones preveían los beneficios de utilizar el turismo como actividad de apoyo para el desarrollo general, pero también indicaban retos y desventajas a los que se enfrentaban los países. Resultados De cara a 2050, el artículo parte de dos supuestos. En primer lugar, la demanda de turismo internacional continuará. En segundo lugar, cualquier futura interrupción de la demanda causada por guerras, terrorismo, epidemias o dificultades económicas será de corta duración y no afectará de forma tan generalizada a la demanda de viajes internacionales como lo hizo el Covid-19. El artículo concluye que los países en desarrollo pueden crear sectores turísticos viables, pero que la sostenibilidad es improbable si no se lleva a cabo una gestión cuidadosa y responsable del sector turístico. Originalidad Este artículo ofrece una «visión interna» de las distintas opciones de desarrollo del turismo sostenible, así como de los retos y oportunidades que conlleva, y hace hincapié en el papel gubernamental en este proceso. Implicaciones prácticas Las opciones de desarrollo turístico deben evaluarse dentro del potencial y las capacidades de cada país. No existe un único modelo de desarrollo. Una iniciativa importante es contribuir a identificar y desarrollar el talento local para el sector turístico, especialmente en lo referente a los requisitos de planificación, política y ejecución. Se debería instar al gobierno y al sector privado a cooperar en las iniciativas de desarrollo.

The ground snow load is used as the reference snow load to estimate the design snow load on roofs. The ground snow load is recommended in Chinese load code for the design of building structures in the applicable jurisdiction; this load needs to be updated regularly by integrating new available snow measurements and new analysis techniques. This study is concentrated on the estimation of extreme snow depth and ground snow load and on snow hazard mapping in China by using historical snow measurement data. A probabilistic model of the snowpack bulk density was developed. For the extreme value analysis of annual maximum snow depth, both the at-site analysis and region of influence approach were applied. Also, several commonly used probabilistic models and distribution fitting methods were considered for the extreme value analysis. For the annual maximum snow depth, it was identified from the at-site analysis results that the number of sites where the lognormal distribution is preferred is greater than that where the Gumbel distribution is preferred. The 50-year return period value obtained from the ROI approach is insensitive to whether the three-parameter lognormal distribution or the generalized extreme value distribution is adopted. Maps of annual maximum snow depth and ground snow load were developed. Comparison of the estimated ground snow load to that recommended in the design code was presented, and potential updating to the ground snow load in the design code was suggested.

Chronic obstructive pulmonary disease (COPD) currently ranks among the top three causes of mortality worldwide, presenting as a prevalent and complex respiratory ailment. Ongoing research has underscored the pivotal role of immune function in the onset and progression of COPD. The immune response in COPD patients exhibits abnormalities, characterized by diminished anti-infection capacity due to immune senescence, heightened activation of neutrophils and macrophages, T cell infiltration, and aberrant B cell activity, collectively contributing to airway inflammation and lung injury in COPD. This review aimed to explore the pivotal role of the immune system in COPD and its therapeutic potential. We conducted a review of immunity and COPD published within the past decade in the Web of Science and PubMed databases, sorting through and summarizing relevant literature. This article examines the pivotal roles of the immune system in COPD. Understanding the specific functions and interactions of these immune cells could facilitate the development of novel therapeutic strategies and interventions aimed at controlling inflammation, enhancing immune function, and mitigating the impact of respiratory infections in COPD patients.