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"Farrell, Michael"
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Deprecation in favour of weather
'I live in the ghetto', certain guys I know sing, and I hear the word...
Journal Article
Investigating the language of special education : listening to many voices
\"Investigating the Language of Special Education guides the reader through the complex issues and ideas pertinent to understanding the language of special education. It responds to some of the subject's most pressing concerns, including the function and effects of language in labelling disabilities and disorders, the extent to which current special educational language reflects legal frameworks and definitions, and whether changes in language can lead to changes in perceiving a 'social reality' of special education. This volume brings clarity to these and other ambiguous areas in special education. Utilising a wide range of theoretical traditions from philosophy, sociology and anthropology, this book aims to raise the reader's awareness of the power as well as the limitations of language in relation to special education. It will therefore be of great interest to educators as well as students and researchers of applied linguistics and disability studies\"-- Provided by publisher.
Book
Writing Australian unsettlement : Modes of Poetic Invention, 1796-1945
\"This book rewrites the history of Australian literature, through reading the unorthodox poetics of colonial life writing, from letters to tree carvings. Farrell examines page, punctuation and grammar to present a new version of Australian literature, including texts by poets, bushrangers, Indigenous stockmen, a Chinese miner and migrant women\" -- Provided by publisher.
Book
Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control
IntroductionChronic non-productive coughing is a major complication of pulmonary disease and can also occur in many individuals without identifiable underlying pathology. The common clinical link in patients with cough is an enhanced sensitivity of the respiratory system to stimuli that subsequently evoke excessive coughing. The aetiology of this ‘cough hypersensitivity syndrome’ is unclear but believed to involve hypersensitivity of the sensory neural pathways that innervate the airways and lungs.MethodsIn the present study, we used functional brain imaging to compare central neural responses to airway stimulation using inhaled capsaicin in healthy people and patients with cough hypersensitivity.ResultsHypersensitivity in response to inhaled capsaicin coincided with elevated neural activity in the midbrain in a region encompassing the nucleus cuneiformis (left: p<0.001; right: p<0.001) and periaqueductal gray (p=0.008) in comparison to normal sensitivity in controls. The enhanced activity noted in the midbrain is similar to that occurring in patients with chronic pain, thus providing empirical evidence to support the notion that cough and pain share neurobiological similarities. Furthermore, patients with cough hypersensitivity displayed difficulty controlling their cough, which manifested as a failure to suppress cough during capsaicin challenge (ie, reduced cough frequency) in controls compared with patients with cough hypersensitivity (p=0.046). Cough suppression was associated with reduced activity in a forebrain network that included the dorsomedial prefrontal and anterior mid-cingulate cortices. Additionally, cough frequency was correlated with activity in the right inferior frontal gyrus (R2=0.6, p<0.001) and right anterior insula (R2=0.6, p<0.001), regions previously implicated in voluntary cough suppression.ConclusionsThese findings provide insight into the central neurobiology of cough hypersensitivity and suggest that both central amplification of cough sensory inputs and reduced capacity to suppress cough motor behaviours define patients with problematic cough.
Journal Article
Microvascular stabilization via blood-brain barrier regulation prevents seizure activity
Blood-brain barrier (BBB) dysfunction is associated with worse epilepsy outcomes however the underlying molecular mechanisms of BBB dysfunction remain to be elucidated. Tight junction proteins are important regulators of BBB integrity and in particular, the tight junction protein claudin-5 is the most enriched in brain endothelial cells and regulates size-selectivity at the BBB. Additionally, disruption of claudin-5 expression has been implicated in numerous disorders including schizophrenia, depression and traumatic brain injury, yet its role in epilepsy has not been fully deciphered. Here we report that claudin-5 protein levels are significantly diminished in surgically resected brain tissue from patients with treatment-resistant epilepsy. Concomitantly, dynamic contrast-enhanced MRI in these patients showed widespread BBB disruption. We show that targeted disruption of claudin-5 in the hippocampus or genetic heterozygosity of claudin-5 in mice exacerbates kainic acid-induced seizures and BBB disruption. Additionally, inducible knockdown of claudin-5 in mice leads to spontaneous recurrent seizures, severe neuroinflammation, and mortality. Finally, we identify that RepSox, a regulator of claudin-5 expression, can prevent seizure activity in experimental epilepsy. Altogether, we propose that BBB stabilizing drugs could represent a new generation of agents to prevent seizure activity in epilepsy patients.
The mechanisms underlying epilepsy development are not well understood. Here the authors show that loss of a key component of the so called blood-brain barrier drives seizures in mice and is also lost in humans with treatment resistant epilepsy
Journal Article
مقدمة في أصول التربية الخاصة
يعد موضوع هذا الكتاب من المواضيع المهمة للنخبة القارئة التي تأخذهم لسبر غور تاريخ ومراحل تطور التربية الخاصة من عدة منظورات مختلفة لتكوين رؤية فلسفية عميقة عن أصول التربية الخاصة كما يأتي هذا الكتاب مساعدا في رسم صورة مختلفة عن الصور النمطية لفهم التربية الخاصة وتوصيل خدماتها حيث من المتوقع أن يسهم هذا الكتاب في اختلاف رؤية القارئ وفلسفته قبل القراءة وبعدها وبفضل الطرح غير التقليدي للمؤلف ويأتي تميز هذا الكتاب كون مؤلفه من المملكة المتحدة وهو ما فرض نمط وطريقة وأسلوب كتابة مغايرة عن معظم الكتب المنشورة باللغة الإنجليزية والتي تسيطر عليها المدرسة الأمريكية في الكتابة وهو ما خلق ميزة نسبية للقارئ للتعرف على أصول التربية الخاصة بعين أوروبية وأمريكية ممزوجة.
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