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"Faulk, Michelle"
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The case of the undercooked burger
\"Learn about E. coli, the round worm A. lumbricoides, hepatitis A, C. jejuni, and Staphylococcus aureus. Then try to guess the disease in three different cases\"-- Provided by publisher.
Book
Functional Conservation in the SIAMESE-RELATED Family of Cyclin-Dependent Kinase Inhibitors in Land Plants
The best-characterized members of the plant-specific SIAMESE-RELATED (SMR) family of cyclin-dependent kinase inhibitors regulate the transition from the mitotic cell cycle to endoreplication, also known as endoreduplication, an altered version of the cell cycle in which DNA is replicated without cell division. Some other family members are implicated in cell cycle responses to biotic and abiotic stresses. However, the functions of most SMRs remain unknown, and the specific cyclindependent kinase complexes inhibited by SMRs are unclear. Here, we demonstrate that a diverse group of SMRs, including an SMR from the bryophyte Physcomitrella patens, can complement an Arabidopsis thaliana siamese (sim) mutant and that both Arabidopsis SIM and P. patens SMR can inhibit CDK activity in vitro. Furthermore, we show that Arabidopsis SIM can bind to and inhibit both CDKA;1 and CDKB1;1. Finally, we show that SMR2 acts to restrict cell proliferation during leaf growth in Arabidopsis and that SIM, SMR1/LGO, and SMR2 play overlapping roles in controlling the transition from cell division to endoreplication during leaf development. These results indicate that differences in SMR function in plant growth and development are primarily due to differences in transcriptional and posttranscriptional regulation, rather than to differences in fundamental biochemical function.
Journal Article
The case of the infected tick
\"Learn about diseases and their symptoms such as Lyme disease, HIV, and Malaria among others\"-- Provided by publisher.
Book
The research equity and diversity initiative (READI): Changing the face of clinical research through community outreach and engagement
Current evidence underscores a need to transform how we do clinical research, shifting from academic-driven priorities to co-led community partnership focused programs, accessible and relevant career pathway programs that expand opportunities for career development, and design of trainings and practices to develop cultural competence among research teams. Failures of equitable research translation contribute to health disparities. Drivers of this failed translation include lack of diversity in both researchers and participants, lack of alignment between research institutions and the communities they serve, and lack of attention to structural sources of inequity and drivers of mistrust for science and research. The Duke University Research Equity and Diversity Initiative (READI) is a program designed to better align clinical research programs with community health priorities through community engagement. Organized around three specific aims, READI-supported programs targeting increased workforce diversity, workforce training in community engagement and cultural competence, inclusive research engagement principles, and development of trustworthy partnerships.
Journal Article
The case of the sneezy popcorn : Annie Biotica solves respiratory system disease crimes
\"Learn about strep throat, Hantavirus, whooping cough, Pneumonia, and the differences between the cold and the flu. Then try to guess the disease in three different cases\"-- Provided by publisher.
BOOK
Data collected using small uncrewed aircraft systems during the TRacking Aerosol Convection interactions ExpeRiment (TRACER)
The main goal of the TRacking Aerosol Convection interactions ExpeRiment (TRACER) project was to further understand the role that regional circulations and aerosol loading play in the convective cloud life cycle across the greater Houston, Texas, area. To accomplish this goal, the United States Department of Energy and research partners collaborated to deploy atmospheric observing systems across the region. Cloud and precipitation radars, radiosondes, and air quality sensors captured atmospheric and cloud characteristics. A dense lower-atmospheric dataset was developed using ground-based remote sensors, a tethersonde, and uncrewed aerial systems (UASs). TRACER-UAS is a subproject that deployed two UAS platforms to gather high-resolution observations in the lower atmosphere between 1 June and 30 September 2022. The University of Oklahoma CopterSonde and the University of Colorado Boulder RAAVEN (Robust Autonomous Aerial Vehicle – Endurant Nimble) were flown at two coastal locations between the Gulf of Mexico and Houston. The University of Colorado Boulder RAAVEN gathered measurements of atmospheric thermodynamic state, winds and turbulence, and aerosol size distribution. Meanwhile, the University of Oklahoma CopterSonde system operated on a regular basis to resolve the vertical structure of the thermodynamic and kinematic state. Together, a complementary dataset of over 200 flight hours across 61 d was generated, and data from each platform proved to be in strong agreement. In this paper, the platforms and respective data collection and processing are described. The dataset described herein provides information on boundary layer evolution, the sea breeze circulation, conditions prior to and nearby deep convection, and the vertical structure and evolution of aerosols. The quality-controlled TRACER-UAS observations from the CopterSonde and RAAVEN can be found at https://doi.org/10.5439/1969004 (Lappin, 2023) and https://doi.org/10.5439/1985470 (de Boer, 2023), respectively.
Journal Article
Can EOS imaging substitute traditional AP pelvis radiographs? A Comparative study
INTRODUCTION:
Young patients followed for hip disorders often require serial imaging and incur significant radiation to the abdomen and pelvis. The EOS imaging system offers a low-radiation alternative. However, consistency with radiographic parameters from conventional radiographs (CR) have not been studied. We evaluated the reliability and validity of EOS imaging in comparison to CR in evaluating acetabular morphology.
METHODS:
48 hips (27 patients, 66.67% female, 14.4 ± 3.6 years old), indicated for open hip preservation procedure between 2015-2017, which had both EOS imaging and AP pelvis CR taken pre-operatively were examined. Both symptomatic and contralateral hips were measured, excluding hips with prior osteotomies.
Three orthopaedic surgeons measured Tonnis angle, lateral center edge angle (LCEA), acetabular depth ratio (ADR), and extrusion index (EI) in both imaging modalities. Images were measured twice, two weeks apart. Reliability was assessed using intraclass correlation coefficients (ICC). Bland-Altman analysis was used to evaluate test-retest agreement and inter-modality agreement.
RESULTS:
Test-retest reliability was excellent for all raters on all tests (ICC range 0.8047 to 0.9714). Inter-rater reliability was also excellent for all measures on both modalities (ICC range 0.8593 to 0.9547). ICC values were consistent across EOS and CR.
By Bland-Altman analysis, test-retest agreement was high, with no statistically significant mean differences in any test or modality (p > 0.6) except LCEA measured on EOS images (p = 0.02), which was 1.16° lower.
Tonnis angle (p < 0.005) and ADR (p < 0.001) were statistically different from EOS to CR. Bias was also not uni-directional across tests: LCEA and ADR were, on average, higher on CR while Tonnis angle and EI were, on average, higher on EOS images. Reliability between the EOS and CR images was excellent for all raters on all tests (ICC range 0.8402 to 0.9458).
DISCUSSION AND CONCLUSION:
LCEA, ADR, EI, and Tonnis angle have consistently high test-retest reliability, test-retest agreement, and inter-observer reliability in both EOS imaging and CR to evaluate acetabular morphology. Inter-modality disagreement was observed between EOS and CR, but the difference was small and likely not clinically significant.
When establishing acetabular morphology, these results suggest that EOS may provide an opportunity to minimize radiation exposure for patients followed long-term for hip pathology while maintaining the accuracy of diagnostic measures.
Table 1.
Reliability between EOS and traditional X-ray modalities for each of three raters, measured by the intra-class correlation coefficient (ICC).1
Table 2.
Agreement between modalities in rater 2 at time point 1 using the Bland-Altman analysis of mean difference. Group means and standard deviation are shown for reference.
Journal Article
The Edinburgh Companion to T. S. Eliot and the Arts
Explores Eliot’s many-sided engagements with painting, sculpture, architecture, music, drama, music hall and cinema, recorded sound, and dance, drawing on newly available sources, archival material, and interart connections.
eBook