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Cobalt-60 is usually used for calibration standard that nowadays, it hard to fabricated. This research aims to fabricate of Sealed Source 46 Sc as alternative Calibration Standard. Sealed source 46 Sc radioactivity was 1.17 ± 0.08 µCi, sealed with an aluminum label. Radiation exposure on the surface opened container is 19.27 ± 0.09 µSv/h, a closed is 10.78 ± 0.15 µSv/h and the distance of 1 m from an open container is 4.40 ± 0.04 µSv/h whereas closed has 2.40 ± 0.04 µSv/h. Multi-channel analyzer γ-spectrometry showed the 46 Sc gamma spectrum similar with characteristics from standard 60 Co source.

The global consumption of poultry is expected to increase by 2032, especially in Asian and European countries. Proper nutrition, including feed additives, plays a role in meeting the global demand for livestock products. In addition, the use of antibiotics as growth promoters resulted in antibiotic resistance issues, leading to the need to investigate alternative methods for replacing the role of antibiotics. The use of probiotic bacteria has proved to improve the growth performance of poultry and suppress pathogenic bacteria growth in the digestive tract. However, micro-environment conditions in the digestive tract affect the survival of probiotic bacteria. Modification of bacteria by encapsulation shows promising potential to protect bacteria from the harsh conditions in the poultry digestive tract. In addition, probiotic encapsulation also showed improvement in performance in poultry. This review will discuss the current encapsulation technology in probiotics applied to poultry and its effects. It also will explore the prospect of encapsulated probiotics, especially in the poultry industry, and its challenge.

Radiosynovectomy is a therapy performed on patients with acute-level arthritis (rheumatoid arthritis) as an alternative solution besides surgery. Radiosynovectomy is performed using a labeled compound with a particle size of 0.5-10 μm labeled with a β radioisotope. Hydroxyapatite (HA) is a 1-10 μm-sized compound found in bones with the components of Calcium (Ca) & Phosphorus (P). Phosphorus-32 (32P) is a radioactive form of Phosphorus which emits pure beta rays and is often used for therapy. Labelling HA with 32P tends to be easy to do with a substitution reaction, because phosphorus is the main constituent of HA. Phosphorus-32 was made by irradiating natural sulfur at the Bandung TRIGA 2000 reactor facility following the 32S (n, p) 32P reaction mechanism. The separation process of Phosphorus-32 was carried out by a distillation method followed by extraction with 0.01 N HCl accompanied by heating for 30 minutes. The Phosphorus-32 solution is then passed through a 3 gr cation exchange resin. Before Phosphorus-32 was used for Labelling of HA, a Radionuclide Purity test was performed with a gamma-MCA spectrophotometer and a Radiochemical Purity test using paper chromatography. The test results showed Phosphorus-32 had Radionuclide Purity > 99.99% and Radiochemical Purity > 96%. 0.5 mCi Phosphorus-32 which meets the quality test requirements is reacted with 7 mg Ha at pH 7. Then it is vortexed at 1500 rpm for 60 minutes with 70 ° C heating. HA-32P is separated using centrifugation into residual and supernatant fractions. Measure the radioactivity of both fractions with a dose calibrator. Labeling Yield HA with Phosphorus-32 was obtained 98%. Furthermore this HA is ready to be used in in vivo tests for radiosynovectomy.

Design of Irradiation Facilities at Grid E-1 of Plate Type Research Reactor Bandung. Plate Type Research Reactor Bandung (PTRRB) core design is one of the result of PTRRB research programs. In the previous study the irradiation facilities at grid E-1 has not been designed and also distribution of thermal, epithermal and fast neutron flux at grid E-1 has not been studied. Since that data is very important especially in radioisotope production and neutron beam tube analysis, therefore in this study irradiation facilities at grid E-1will be designed. Previous PTRRB core design is a base for designing irradiation facilities at grid E-1. Considering geometrical of grid E-1 and aluminum tube dimension there are three possibilities aluminum tube configuration. The configurations are configuration 1, 2 and 3. Each configuration was modelled as arrangement of four aluminum tubes and each tube filled by four aluminum irradiation capsules. That configuration was starting point to made MCNP PTRRB reactor core model so there are three MCNP PTRRB reactor core model. MCNP PTRRB reactor core model is needed because MCNP software are computer program for calculating excess reactivity and neutron flux distribution at grid E-1. Result excess reactivity calculation of three configuration indicate that after installing irradiation tube excess reactivity is lower than of limit excess reactivity value 10.9 % of neutronic safety criteria of PTRRB design. Based on neutronic safety criteria, the three configuration is accepted for irradiation facilities PTRRB. Neutron flux calculation result of three configuration reveals that the highest neutron flux is located at capsule no II and III. Profile of thermal neutron flux, epithermal neutron flux and fast neutron flux of three configurations are similar. Neutron flux of thermal, epithermal and fast neutron of three configuration are slightly different. The calculation result reveal that highest thermal neutron flux at grid E-1 is 2.70 × 1013(n/cm2.sec) at configuration 2. Based on neutronic safety criteria and thermal neutron flux, configuration 2 is appropriate for irradiation facilities of PTRRB.

Research related to bone fractures is currently focused on accelerating healing time with fewer complications. In some cases related to biological and mechanical factors that interfere with the healing process, it will take a longer time to heal. Hydroxyapatite (HA) is a promising material used as a scaffold for bone implants with various advantages. The in vivo biodistribution of Sc-46 labeled composite (HA-Chitosan-Collagen) remains unclear. In this research, Scandium-46 was prepared as a non-carrier free radioisotope solution by irradiating 100 mg Sc2O3 target in TRIGA 2000 Reactor Bandung. In vivo experiment was performed on Sprague Dawley rats weighing approximately 250 g. Rats bone implant model was divided into two groups with n = 3 per time point. The Sc-46 labeled composite (HA-Chitosan-Collagen) have implanted to rats femur 10 mg with radioactivity 10 μCi. Rats were euthanized using accepted protocol and all organs were counted for radioactivity using Wipe Test Counter with NaI(Tl) detector. The percent of radioactivity measured per gram of tissue weight (%ID/g). Biodistribution results showed that Sc-46 labeled composite (HA-Chitosan-Collagen) using the bone-implant method were significantly different compared with the normal bone for 1, 3, and 8 days of the time interval with p<0.05. These observations suggest that Composite (HA-Chitosan-Collagen) is available for bone implants and remains at the implant site until bone recovery.

The coronavirus disease 2019 (COVID-19) has become a substantial threat to the international health sector and the global economy. As of 26 December 2021, the number of mortalities resulting from COVID-19 exceeded 5.3 million worldwide. The absence of an effective non-vaccine treatment has prompted the quest for prophylactic agents that can be used to combat COVID-19. This study presents the feasibility of chicken egg yolk antibody (IgY) anti-receptor-binding domain (RBD) spike SARS-CoV-2 as a strong candidate to neutralize the virus for application in passive immunization. For the purpose of preclinical studies, we radiolabeled IgY anti-RBD spike SARS-CoV-2 with radionuclide iodine-131. This allowed us to evaluate several biological characteristics of IgY in vitro, in vivo, and ex vivo. The preclinical data suggest that IgY anti-RBD spike SARS-CoV-2 could specifically bind to the SARS-CoV-2 antigens; however, little uptake was observed in normal cells (MRC-5) (<2%). Furthermore, the ex vivo biodistribution study revealed that IgY predominantly accumulated in the trachea of normal mice compared to other organs. We also found that IgY possessed a good safety profile when used as an intranasal agent. Taken together, we propose that IgY anti-RBD spike SARS-CoV-2 has the potential for application in passive immunization against COVID-19.

Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified as the peripheral benzodiazepine receptor (PBR). TSPO involves in a broad number of biochemical events, such as steroidogenesis, mitochondrial cholesterol transport, cell survival and death, cell proliferation, and carcinogenesis. Several investigations have reported the roles of TSPO in various types of cancers, including colorectal cancer, brain cancer, melanoma, breast cancer, prostate cancer, and lung cancer. It was found that TSPO is upregulated in cancer cells, and it appears that its expression is parallel with an aggressive phenotype and/or poor prognosis. As a consequence, there is great potential for developing diagnostic and prognostic tools targeting the TSPO. In this regard, several radioligands targeting the TSPO have been identified, and some of the candidates have advanced to clinical trials. In recent years, image-guided surgery using hybrid probes bearing radioactive and fluorescence molecules has demonstrated promising outcomes in animal and human studies, and thus might serve as a valuable surgical navigator during cancer surgery. In general, current hybrid probes are built from various molecular platforms, including small molecules, nanoparticles, and antibodies. Although several TSPO-targeted imaging probes have been developed, their development for image-guided surgery of cancers is scarce. This review highlights recent findings of the involvement of TSPO in carcinogenesis, and provides a new perspective on the potential application of TSPO-targeted hybrid probes for image-guided surgery.