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"Feldman, Liane"
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Incidence of incisional hernia in the specimen extraction site for laparoscopic colorectal surgery: systematic review and meta-analysis
by
Lee, Lawrence
,
Fried, Gerald M.
,
Liberman, Sender
in
Abdominal Surgery
,
Colectomy - adverse effects
,
Colectomy - methods
2017
Introduction
The incidence of incisional hernia(IH) may be affected by the choice of specimen extraction incision. The objective of this study was to perform a systematic review and meta-analysis comparing the incidence of IH after midline and off-midline incisions in patients undergoing laparoscopic colorectal surgery.
Methods
A systematic search was performed according to PRISMA guidelines to identify all comparative studies from January 1991–August 2016 on the incidence of IH after midline and off-midline(transverse or Pfannenstiel) incisions in patients undergoing laparoscopic colorectal surgery. Case series and studies reporting the IH after stoma site extraction, SILS, or NOTES were excluded. The MINORS instrument was used for quality assessment for observational studies. Weighted estimates were calculated using a random-effects model.
Results
A total of 17 articles were identified and included for meta-analysis, 16 of which were observational studies and 1 was an RCT. The mean MINORS score for observational studies was 12.9 (SD 3.2, range 7–17). Sample sizes in the midline (mean 185, range 20–995) and off-midline(mean 184, range 20–903) groups were similar. Follow-up ranged from 17.3 to 42 months. The pooled incidence of IH was 10.6% (338/3177) in midline, 3.7% (48/1314) in transverse, and 0.9% (9/956) in Pfannenstiel incisions. IH was significantly higher in the midline compared to off-midline groups (weighted OR 4.1, 95% CI 2.0–8.3,
I
2
= 79.7%,
p
for heterogeneity <0.001). Midline incisions were also at higher risk of IH versus transverse (weighted OR 3.0, 95% CI 1.4–6.7,
I
2
= 72.7%,
p
for heterogeneity <0.001) and Pfannenstiel (weighted OR 8.6, 95% CI 3.0–24.6,
I
2
= 43.5%,
p
for heterogeneity = 0.101) incisions. There was no publication bias according the funnel plot or statistically (Egger’s
p
= 0.336).
Conclusions
Midline incisions for specimen extraction in laparoscopic colorectal surgery are at significantly higher risk of IH compared to off-midline (transverse or Pfannenstiel) incisions, but these data are of poor quality and heterogeneous.
Journal Article
What outcomes are important in the assessment of Enhanced Recovery After Surgery (ERAS) pathways?
by
Lee, Lawrence
,
Fiore, Julio
,
Feldman, Liane S.
in
Anesthesiology
,
Cardiology
,
Clinical outcomes
2015
Purpose
The purpose of this narrative review is to provide a framework from which to measure the outcomes of Enhanced Recovery After Surgery (ERAS) programs.
Principle findings
We define the outcomes of
recovery
from the perspective of different stakeholders and time frames. There is no single definition of recovery. There are overlapping phases of recovery which are of particular interest to different stakeholders (surgeons, anesthesiologists, nurses, patients and their caregivers), and the primary outcome of interest may vary depending on the phase and the perspective. In the earliest phase (from the end of the surgery to discharge from the postanesthesia care unit [PACU]), biologic and physiologic outcomes are emphasized. In the intermediate phase (from PACU to discharge from the hospital), symptoms related to pain and gastrointestinal function as well as basic activities are important. Studies of ERAS pathways have reported clinical outcomes and symptoms, including complications, hospital stay, mobilization, and gastrointestinal function, largely during hospitalization. Nevertheless, patients define recovery as return to normal functioning, a process that occurs over weeks to months (late phase). Outcomes reflecting functional status (e.g., physical activity, activities of daily living) and overall health (e.g., quality of life) are important in this phase. To date, few studies reporting the effectiveness of ERAS pathways compared with conventional care have included functional status or quality-of-life outcomes, and there is little information about recovery after discharge from hospital.
Conclusion
Recovery after surgery is a complex construct. Different outcomes are important at different phases along the recovery trajectory. Measures for quantifying recovery in hospital and after discharge are available. A consensus-based core set of outcomes with input from multiple stakeholders would facilitate research reporting.
Journal Article
Fundamentals of Laparoscopic Surgery simulator training to proficiency improves laparoscopic performance in the operating room—a randomized controlled trial
by
Fayez, Raad
,
Vassiliou, Melina C.
,
Fried, Gerald M.
in
Biological and medical sciences
,
Cholecystectomy
,
Cholecystectomy, Laparoscopic - education
2010
The purpose of this study was to assess whether training to proficiency with the Fundamentals of Laparoscopic Surgery (FLS) simulator would result in improved performance in the operating room (OR).
Nineteen junior residents underwent baseline FLS testing and were assessed in the OR using a validated global rating scale (GOALS) during elective laparoscopic cholecystectomy. Those with GOALS scores ≤15 were randomly assigned to training (n = 9) or control (n = 8) groups. An FLS proficiency-based curriculum was used in the training group. Scoring on FLS and in the OR was repeated after the study period. Evaluators were blinded to randomization status.
Sixteen residents completed the study. There were no differences in baseline simulator (49.1 ± 17 vs 39.5 ± 16,
P = .27) or OR scores (11.3 ± 2.0 vs 12.0 ± 1.8;
P = .47). After training, simulator scores were higher in the trained group (95.1 ± 4 vs 60.5 ± 23,
P = .004). OR performance improved in the control group by 1.8 to 13.8 ± 2.2 (
P = .04), whereas the trained group improved by 6.1 to 17.4 ± 1.9 (
P = .0005 vs control;
P < .0001 vs baseline).
This study clearly demonstrates the educational value of FLS simulator training in surgical residency curricula.
Journal Article
Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study
by
Wongyingsinn, Mingkwan
,
Kim, Do Jun
,
Liberman, Alexander S.
in
Abdominal Surgery
,
Aged
,
Anxiety
2013
Background
Patients undergoing colorectal cancer resections are at risk for delayed recovery. Prehabilitation aims to enhance functional capacity preoperatively for better toleration of surgery and to facilitate recovery. The authors previously demonstrated the limited impact of a prehabilitation program using exercise alone. They propose an expanded trimodal prehabilitation program that adds nutritional counseling, protein supplementation, and anxiety reduction to a moderate exercise program. This study aimed to estimate the impact of this trimodal program on the recovery of functional capacity compared with standard surgical care.
Methods
Consecutive patients were enrolled in this pre- and postintervention study over a 23-month period. The postoperative recovery for 42 consecutive patients enrolled in the prehabilitation program was compared with that of 45 patients assessed before the intervention began. The primary outcome was functional walking capacity (6-min walk test [6MWT]). The secondary outcomes included self-reported physical activity (CHAMPS questionnaire) and health-related quality of life (SF-36). Data are expressed as mean ± standard deviation or median (interquartile range [IQR]) and were analyzed using Chi-square and Student’s
t
test. All
p
values lower than 0.05 were considered significant.
Results
The prehabilitation and control groups were comparable in terms of age, gender, body mass index (BMI) and American Society of Anesthesiology (ASA) class. There was no difference in walking capacity at the first assessment (6MWT distance, 422 ± 87 vs 402 ± 57 m;
p
= 0.21). During the prehabilitation period lasting a median of 33 days (range, 21–46 days), functional walking capacity improved by 40 ± 40 m (
p
< 0.01). The postoperative complication rates and the hospital length of stay were similar. The patients in the prehabilitation program had better postoperative walking capacity at both 4 weeks (mean difference, 51.5 ± 93 m;
p
= 0.01) and 8 weeks (mean difference, 84.5 ± 83 m;
p
< 0.01). At 8 weeks, 81 % of the prehabilitated patients were recovered compared with 40 % of the control group (
p
< 0.01). The prehabilitation group also reported higher levels of physical activity before and after surgery.
Conclusion
In this pilot study, a 1-month trimodal prehabilitation program improved postoperative functional recovery. A randomized trial is ongoing (NCT01356264).
Journal Article
Design and Evaluation of Augmented Reality-Enhanced Robotic System for Epidural Interventions
2024
The epidural injection is a medical intervention to inject therapeutics directly into the vicinity of the spinal cord for pain management. Because of its proximity to the spinal cord, imprecise insertion of the needle may result in irreversible damage to the nerves or spinal cord. This study explores enhancing procedural accuracy by integrating a telerobotic system and augmented reality (AR) assistance. Tele-kinesthesia is achieved using a leader–follower integrated system, and stable force feedback is provided using a novel impedance-matching force rendering approach. In this domain, augmented reality employs a magnetic-tracker-based approach for real-time 3D model projection onto the patient’s body, aiming to augment the physician’s visual field and improve needle insertion accuracy. Preliminary results indicate that our AR-enhanced robotic system may reduce the cognitive load and improve the accuracy of ENI, highlighting the promise of AR technologies in complex medical procedures. However, further studies with larger sample sizes and more diverse clinical settings must comprehensively validate these findings. This work lays the groundwork for future research into integrating AR into medical robotics, potentially transforming clinical practices by enhancing procedural safety and efficiency.
Journal Article
Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials
2022
Excessive opioid prescribing after surgery has contributed to the current opioid crisis; however, the value of prescribing opioids at surgical discharge remains uncertain. We aimed to estimate the extent to which opioid prescribing after discharge affects self-reported pain intensity and adverse events in comparison with an opioid-free analgesic regimen.
In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, Scopus, AMED, Biosis, and CINAHL from Jan 1, 1990, until July 8, 2021. We included multidose randomised controlled trials comparing opioid versus opioid-free analgesia in patients aged 15 years or older, discharged after undergoing a surgical procedure according to the Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity definition (minor, moderate, major, and major complex). We screened articles, extracted data, and assessed risk of bias (Cochrane's risk-of-bias tool for randomised trials) in duplicate. The primary outcomes of interest were self-reported pain intensity on day 1 after discharge (standardised to 0–10 cm visual analogue scale) and vomiting up to 30 days. Pain intensity at further timepoints, pain interference, other adverse events, risk of dissatisfaction, and health-care reutilisation were also assessed. We did random-effects meta-analyses and appraised evidence certainty using the Grading of Recommendations, Assessment, Development, and Evaluations scoring system. The review was registered with PROSPERO (ID CRD42020153050).
47 trials (n=6607 patients) were included. 30 (64%) trials involved elective minor procedures (63% dental procedures) and 17 (36%) trials involved procedures of moderate extent (47% orthopaedic and 29% general surgery procedures). Compared with opioid-free analgesia, opioid prescribing did not reduce pain on the first day after discharge (weighted mean difference 0·01cm, 95% CI –0·26 to 0·27; moderate certainty) or at other postoperative timepoints (moderate-to-very-low certainty). Opioid prescribing was associated with increased risk of vomiting (relative risk 4·50, 95% CI 1·93 to 10·51; high certainty) and other adverse events, including nausea, constipation, dizziness, and drowsiness (high-to-moderate certainty). Opioids did not affect other outcomes.
Findings from this meta-analysis support that opioid prescribing at surgical discharge does not reduce pain intensity but does increase adverse events. Evidence relied on trials focused on elective surgeries of minor and moderate extent, suggesting that clinicians can consider prescribing opioid-free analgesia in these surgical settings. Data were largely derived from low-quality trials, and none involved patients having major or major-complex procedures. Given these limitations, there is a great need to advance the quality and scope of research in this field.
The Canadian Institutes of Health Research.
Journal Article
Ambulatory sleeve gastrectomy: a prospective feasibility and comparative study of early postoperative morbidity
2023
BackgroundGiven its short procedure time and low morbidity, there is enthusiasm to perform sleeve gastrectomy (SG) in an outpatient setting. However, most relevant studies include an overnight stay at a medical facility (≤ 24-h). Hence, we investigated the feasibility and safety of a same-day discharge (SDD) protocol for laparoscopic SG.MethodsIn a prospective pilot study (02/01/2021–02/28/2022), all patients planned for SG were screened for eligibility. Patients met the inclusion criteria if they were ≤ 65 years old, without major comorbidity, and lived close to the hospital. Postoperatively, patients who met discharge criteria were sent home directly from the recovery room. Patients were called the same night and the next morning. Feasibility was defined as discharge on the day of surgery without emergency department (ED) visit or readmission within 24-h. Secondary outcomes, including 90-day morbidity, were compared to patients who met inclusion criteria but chose a same-day admission (SDA) approach during the same study period. Descriptive statistics are displayed as count (percentage) and median (interquartile range).ResultsA total of 320 patients were planned for SG during the study period, 229 of whom met eligibility criteria and underwent SG with 56 agreeing to SDD-SG while 173 opted for SDA-SG. Baseline characteristics were all similar between both groups except for obstructive sleep apnea being more prevalent in SDA-SG group (38.2% vs. 16.1%; P < 0.001). Operative characteristics including procedure time were similar between both groups. Successful SDD-SG was achieved in 54(96%) of patients with a median of 6.0(1.0) hours of stay in the recovery room. Ninety-day morbidity was similar between SDD-SG and SDA-SG groups (1.8% vs. 6.9%, respectively; P = 0.196).ConclusionA SDD protocol for laparoscopic SG was feasible and safe in selected patients. Larger studies that evaluate patient reported outcomes and include bypass-type procedures may be needed to guide safe use of ambulatory bariatric surgery.
Journal Article
Factors influencing surgeon well-being: qualitatively exploring the joy of surgery
2023
BackgroundThere has been considerable research into burnout but much less into how surgeons thrive and find joy. This study, conducted by the SAGES Reimagining the Practice of Surgery Task Force, explored factors influencing surgeon well-being, the eventual goal being translating findings into tangible changes to help restore the joy in surgery.MethodsThis was a qualitative, descriptive study. Purposive sampling ensured representation across ages, genders, ethnicities, practice types, and geographies. Semi-structured interviews were recorded and transcribed. We coded inductively, finalized the codebook by consensus, and then constructed a thematic network. Global themes formed our conclusions; organizing themes gave additional detail. Analysis was facilitated by NVivo.ResultsWe interviewed 17 surgeons from the US and Canada. Total interview time was 15 hours. Our global and organizing themes were:Stressors (Work–life Integration, Administration-related Concerns, Time and Productivity Pressures, Operating Room Factors, and Lack of Respect).Satisfaction (Service, Challenge, Autonomy, Leadership, and Respect and Recognition).Support (Team, Personal Life, Leaders, and Institutions).Values (Professional and Personal).Suggestions (Individual, Practice, and System level).Values, stressors, and satisfaction influenced perspectives on support. Experiences of support shaped suggestions. All participants reported stressors and satisfiers. Surgeons at all stages enjoyed operating and being of service. Supports and suggestions included compensation and infrastructure, but human resources were most critical. To experience joy, surgeons needed high-functioning clinical teams, good leaders/mentors, and supportive family/social networks.ConclusionsOur results indicated organizations could (1) better understand surgeons’ values, like autonomy; (2) provide more time for satisfiers, like patient relationship building; (3) minimize stressors, like time and financial pressures; and (4) at all levels focus on (4a) building teams and leaders and (4b) giving surgeons time and space for healthy family/social lives. Next steps include developing an assessment tool for individual institutions to build “joy improvement plans” and to inform surgical associations’ advocacy efforts.
Journal Article
Evaluation and stages of surgical innovations
by
Aronson, Jeffrey K
,
Feldman, Liane S
,
Barkun, Jeffrey S
in
Biomedical Research
,
Diffusion of Innovation
,
Evaluation Studies as Topic
2009
Surgical innovation is an important part of surgical practice. Its assessment is complex because of idiosyncrasies related to surgical practice, but necessary so that introduction and adoption of surgical innovations can derive from evidence-based principles rather than trial and error. A regulatory framework is also desirable to protect patients against the potential harms of any novel procedure. In this first of three Series papers on surgical innovation and evaluation, we propose a five-stage paradigm to describe the development of innovative surgical procedures.
Journal Article
Watchful waiting for large primary nonparasitic splenic cysts
by
Di Lena, Élise
,
Safa, Nadia
,
Kaneva, Pepa
in
Abdominal Pain - etiology
,
Abdominal Pain - therapy
,
Adult
2023
Primary nonparasitic splenic cysts (NPSC) are typically diagnosed incidentally. The management of large (≥ 5 cm) asymptomatic cysts remains controversial; there is a lack of evidence guiding management. The purpose of this study was to describe the outcomes of nonoperative management of large NPSC.
Patients diagnosed with NPSC between January 2004 and December 2019 were identified at our academic institution. Adult patients with an NPSC of at least 5 cm who had at least 1 additional hospital visit were included. Data are presented as medians with interquartile ranges (IQR).
We identified 512 medical records that included the term splenic cyst during the study period. Sixty-eight of the patients had no reported cyst size, 410 had cysts smaller than 5 cm, 1 patient underwent an elective splenectomy at another institution and 12 patients were excluded for other reasons; 21 patients with cysts of at least 5 cm were included in the study. Eight symptomatic patients underwent surgery at our institution. Of these, 2 presented acutely: 1 with hemoperitoneum who required admission for transfusions and later underwent elective laparoscopic splenectomy and 1 with increasingly severe abdominal pain who underwent laparoscopic cyst unroofing. The remaining 6 symptomatic patients had elective surgery for pain (4 cyst unroofing, 1 total splenectomy, 1 partial splenectomy). Thirteen patients were asymptomatic (10 female, median age 49.2 [IQR 38.1 to 64.6] yr). Two of these patients chose to undergo elective surgery. The remaining 11 asymptomatic patients, with a median initial cyst size of 8.0 (IQR 5.3 to 10.8) cm, were followed for a median of 31.0 (IQR 23.5 to 71.0) months. There was no change in median cyst size (0 [IQR −1 to 0] cm), and none of these patients underwent intervention for their NPSC.
Asymptomatic patients managed nonoperatively for large NPSC did not become symptomatic or require intervention during the study period. This supports watchful waiting with serial radiologic and clinical monitoring for asymptomatic large NPSC.
Les kystes spléniques non parasitaires primaires (KSNPP) sont généralement découverts fortuitement. La prise en charge des kystes volumineux (≥ 5 cm) asymptomatiques ne fait pas l’unanimité; les données probantes manquent pour orienter le traitement. Cette étude avait pour but de décrire les résultats d’une prise en charge non chirurgicale des KSNPP.
Nous avons identifié les patients ayant reçu un diagnostic de KSNPP entre janvier 2004 et décembre 2019 dans notre établissement universitaire. Nous avons inclus les patients adultes porteurs d’un KSNPP d’au moins 5 cm qui avaient consulté au moins 1 autre fois à l’hôpital. Les données sont présentées sous forme de médianes et d’écarts interquartiles (ÉI).
Nous avons recensé 512 dossiers médicaux incluant le terme kyste splénique durant la période de l’étude. Chez 68 patients, la taille du kyste n’était pas indiquée; 410 avaient un kyste de moins de 5 cm; 1 patient a subi une splénectomie non urgente dans un autre établissement et 12 ont été exclus pour d’autres raisons; 21 patients porteurs d’un kyste d’au moins 5 cm ont été retenus pour l’étude. Huit patients symptomatiques ont subi une chirurgie dans notre établissement. Parmi eux, 2 étaient des cas urgents : 1 cas d’hémopéritoine pour lequel le patient a dû être hospitalisé pour des transfusions et a ensuite subi une splénectomie laparoscopique non urgente, et 1 cas d’intense douleur abdominale croissante pour lequel le patient a subi une fenestration laparoscopique. Les 6 autres patients symptomatiques ont subi une chirurgie non urgente pour la douleur (4 fenestrations, 1 splénectomie totale, 1 splénectomie partielle). Treize patients étaient asymptomatiques (10 femmes, âge médian 49,2 [écart interquartile (ÉI) de 38,1 à 64,6] ans). Deux d’entre eux ont opté pour la chirurgie non urgente. Les 11 patients asymptomatiques restants, dont la taille médiane des kystes initiaux était de 8,0 (EI de 5,3 à 10,8) cm, ont été suivis pendant une durée médiane de 31,0 (ÉI de 23,5 à 71,0) mois. On n’a noté aucun changement de la taille médiane des kystes (0 [ÉI de −1 à 0] cm) et aucun de ces patients n’a subi d’intervention pour son KSNPP.
Les patients asymptomatiques traités non chirurgicalement pour un KSNPP volumineux ne sont pas devenus symptomatiques et n’ont pas été obligés d’être opérés pendant la période de l’étude. Cela milite en faveur de l’attente vigilante, avec suivi radiologique et clinique, pour les cas de KSNPP volumineux asymptomatiques.
Journal Article