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Background. The local recurrence rate of triple-negative breast cancer (TNBC) can be as high as 12%.The standard treatment for early-stage TNBC is breast-conserving surgery (BCS), followed by postoperative radiotherapy with or without chemotherapy. However, detection of the local recurrence of the disease after radiotherapy is a major issue. Objective. The aim of this study was at investigating the role of dynamic and functional magnetic resonance imaging (MRI) during follow-up after BCS and radiotherapy with/without chemotherapy to differentiate between locoregional recurrence and postoperative fibrosis. Patients and Methods. This prospective study was conducted at the oncology, radiology, and pathology departments, Tanta University. It involved 50 patients with early-stage TNBC who were treated with BCS, followed by radiotherapy with/without chemotherapy. The suspected lesions were evaluated during the follow-up period by sonomammography. All patients were subjected to MRI, including conventional sequences, diffusion-weighted imaging (DWI), and dynamic postcontrast study. Results. Ten cases were confirmed as recurrent malignant lesions. After contrast administration, they all exhibited irregular T1 hypodense lesions of variable morphology with diffusion restriction and positive enhancement. Eight cases displayed a type III curve, while two showed a type II curve. Histopathological assessment was consistent with the MRI findings in all eight cases. The combination of the data produced by DWI-MRI and dynamic contrast-enhanced (DCE) MRI resulted in 100%sensitivity, 92.5% specificity, 90.9% positive predictive value, 100% negative predictive value, and 98% accuracy. Conclusion. Combination of DWI-MRI and DCE-MRI could have high diagnostic value for evaluating postoperative changes in patients with TNBC after BCS, followed by radiotherapy with/without chemotherapy. Trial Registrations. No trial to be registered.

Along with the increasingly high level of personal digital media consumption, the online promotional activities are constantly and dynamically growing now a days. Some of these digital promotional activities are the use of the online ads on the social media platforms, or the use of the famous influencers, in a way to market the products. The success of the social media advertising relies that it is a tool with low-cost and effective source of medium for advertisers to publicize about their products in the convenient time and place for customers, and meet and satisfy the consumers' needs and change their purchasing behavior's in the favor of the company's profit at the end of the day. Advertising ethics research has traditionally concentrated on the influence of advertising on consumers or the society in general, and with the flourishing of social media ads, many ethical issues started to raise and appear. The purpose of this paper is to study the significance of ethical issues in social media (Facebook) advertising, and to examine the issue of advertising ethics in social media ads, the study will depend on a questionnaire as a collective tool will be applied on 201 consumers of social media users who bought products through Facebook. The study concluded that Facebook is becoming a daily routine habit now a days. It is clear from the survey statistics that the majority, which is 51%, spends 1-3 hours on Facebook daily and 16.1% of participants spend 4-6 hours daily on Facebook. Talking about the importance of the influencers, it was preferred by 60.6% of the respondents. The point is that it creates brand familiarity in just minutes of the video or by the post posted by the influencers. Thus, the influencers are acting as the mediators in disseminating the information and facilitating its dissemination to their on-line followers, concerning how confident are they when they leave their personal contacts and information when buying online products, 37.5% were moderately confident, 17.9% not at all confident, Concerning privacy if it prevents customers from buying online products 31.7% about half the time, 27.2% once in a while, 21.1% most of the time, 13.9% never. Concerning if the policies on Facebook or online purchasing pages are clear, 34.8% equally between most of them, and minorities, while 30.3% most of them.

Systemic therapy improves the survival and quality of life of patients with advanced stage non-small cell lung cancer (NSCLC). Several new therapeutic options have emerged for advanced NSCLC, incorporating novel cytotoxicity agents (taxanes, gemcitabine, pemetrexed) and molecular-targeted agents (erlotinib, bevacizumab) and the optimal prognostic marker for survival remains unclear. The aim of the present study was to assess the prognostic value of the clinicopathologic features and excision repair cross-complementation group-1 (ERCC1) in locally advanced NSCLC patients that received cisplatin-based chemotherapy. Clinical data concerning 80 patients with histopathologically confirmed non-small cell lung cancer who are planned to receive cisplatin-based adjuvant chemotherapy were collected. The protein expression levels for ERCC1 are immunohistochemical examined in 80 patients. The relationship between the ERCC1 protein expression level and the clinical outcomes of the patients is then observed. The 3-year survival rate and median survival time of stage III NSCLC received chemotherapy with/without concurrent chemoradiotherapy were 20 % and 10 months, respectively. Survival of patients with ERCC1-negative tumors was significantly longer than those with ERCC1-positive tumors ( p  = 0.0001). Prognostic factors with overall survival were performance status, cigarette smoking, stage, weight loss and ERCC1. While as regard progression-free survival prognostic factors were stage, weight loss, ERCC1 and degree of positivity of ERCC1 progression. It was found that ERCC1 protein expression might play an important role in the prognosis of locally advanced NSCLC patients treated with cisplatin-based adjuvant chemotherapy.

Social media offers new ways of communication on the internet and allow interactive activities through different platforms and applications like: Facebook, Twitter, Instagram, YouTube and TikTok. Social media also allows users the possibility of constructing, at least in part, their personal identity in a way that is different from what happens in physical reality. The main aim of the study is to explore how social media empowers physical disables (Mentally/ Physiology/ Down syndrome) influencers to be socially included in the society and how they can inspire audience, and how audience accept them as a part of the community. Disability inclusion means understanding the relationship between the way people function and how they participate in society and making sure everybody has the same opportunities to participate in every aspect of life to the best of their abilities and desires. The study will depend on conducting a survey which will be applied on (300) respondents males/females from age 18 to 55, from different social categories.

This study investigates the impact of technology use on the academic motivation and performance of mass communication students, focusing on how digital tools enhance learning and engagement. It begins by recognizing that technology has become an inseparable part of students' daily lives, serving purposes of entertainment, research, and education. The author argues that integrating technology into education is no longer optional but essential to meet the demands of new generations and align with global academic standards. The study outlines several reasons for adopting technology in media education, including the development of research skills, fostering interaction, and building new learning communities. It also highlights that some institutions have already shifted toward e-book systems and online platforms instead of printed curricula. Findings reveal that technology integration helps capture student attention, simplify complex subjects, and increase classroom participation. Based on surveys and field analysis of both students and faculty, the research concludes that technological tools significantly improve academic motivation and performance. However, challenges remain, such as the technological gap between instructors and students and the ongoing need for training in new tools. The study recommends strategic planning for the balanced integration of technology into curricula to maximize benefits while minimizing drawbacks. Abstract Written by Dar AlMandumh, 2025, Using AI

Climate change affects aquaculture to a significant extent, while one of the primary threats to Nile tilapia ( Oreochromis niloticus ) growth and health is suboptimal temperatures. The objective of this study was to assess the effects of Amphora coffeaeformis powder and extract on the growth performance and health status of tilapia grown in suboptimal temperature (21 °C). A total of 180 fish (31.39 ± 0.5 g) were randomly allocated into six groups, each with three replicates. The control group was fed a basal diet. The second and third groups were supplemented with 50 g kg −1 (AMP50) and 70 g kg −1 (AMP70) of A. coffeaeformis powder, respectively. The fourth and fifth groups received 50 g kg −1 (AME50) and 70 g kg −1 (AME70) of A. coffeaeformis extract, respectively. The sixth group (OXY) was fed a diet with 500 mg kg⁻ 1 of oxytetracycline. After a 60-day feeding trial, all fish were challenged with Aeromonas sobria . The findings indicated that the extract of A. coffeaeformis , particularly at a concentration of 70 g kg −1 diet, significantly enhanced growth performance, hematological and biochemical parameters, antioxidant and immunological markers. Additionally, it notably increased resistance against A. sobria . These results suggest that A. coffeaeformis supplementation, particularly AME at 70 g kg −1 , effectively mitigates suboptimal temperature effects on Nile tilapia productivity by enhancing growth, health, and disease resistance.

The utilization of digital technology has grown rapidly in the past three decades. With this rapid increase, cell phones emit electromagnetic radiation; that is why electromagnetic field (EMF) has become a substantial new pollution source in modern civilization, mainly having adverse effects on the brain. While such a topic attracted many researchers’ scopes, there are still minimal discoveries made regarding chronic exposure to EMF. The extensive use of cell phones may affect children's cognition even indirectly if parents and guardians used their phones repeatedly near them. This study aims to investigate possible lipoic acid (LA) effects on cognitive functions and hippocampal structure in young male rats exposed to electromagnetic fields (EMF) emitted from multiple cell phones. Forty young male Wistar rats were randomly allocated into three groups: control, multiple cell phones-exposed and lipoic acid-treated rats. By the end of the experimental period, the Morris water maze was used as a cognitive test. The rats were sacrificed for the collection of serum and hippocampal tissue. These serum samples were then utilized for assessment of Liver function tests. The level ofglutamate, acetylcholine (Ach) and malondialdehyde (MDA) was estimated, in addition to evaluating the expression of autophagy-related protein-7 (Atg7) and Sirt1 genes. The left hippocampal specimens were used for histopathological studies. Results showed that multiple cell phone-exposed rats exhibited shorter latency time to reach the platform by the fifth day of training; additionally, there was a reduction in consolidation of spatial long-term memory. Correspondingly, there was an elevation of hippocampal Ach, glutamate, and MDA levels; accompanied by up-regulation of hippocampal Sirt1 and Atg7 gene expression. Compared to the EMF-exposed group, LA administration improved both learning and memory, this was proved by the significant decline in hippocampal MDA and Ach levels, the higher hippocampal glutamate, the downregulated hippocampal Sirt1 gene expression and the upregulated Atg7 gene expression. In conclusion, EMF exposure could enhance learning ability; however, it interfered with long-term memory consolidation shown by higher hippocampal Ach levels. Lipoic acid treatment improved both learning and memory by enhancing autophagy and hippocampal glutamate level and by the reduced Ach levels and Sirt1 gene expression.

Data on the prevalence and correlates of rapid eye movement (REM)-related obstructive sleep apnea (REM-OSA) in narcolepsy remains limited. This study aimed to assess the prevalence and independent associated factors with OSA and REM-OSA in patients with narcolepsy, and to compare the distribution of REM-OSA between patients with narcolepsy and matched controls without narcolepsy. This retrospective study of a prospectively collected cohort included 190 adult patients with narcolepsy (narcolepsy type 1 [NT1] = 119, narcolepsy type 2 [NT2] = 71) who underwent polysomnography and multiple sleep latency test at the University Sleep Disorders Center, King Saud University Medical City, between January 2007 and February 2022. REM-OSA was defined as an apnea-hypopnea index (AHI) ≥5, AHI-REM/AHI-non-rapid eye movement (NREM) ≥2, AHI-NREM <8, and REM sleep duration >10.5 minutes. A total of 106 patients with narcolepsy were diagnosed with OSA. A control group of 122 patients with OSA but without narcolepsy, matched by age, sex, AHI, and BMI, was used for comparison. Logistic regression identified independent associated factors with OSA and REM-OSA. OSA was diagnosed in 106 patients with narcolepsy (55.8%). REM-OSA was present in 26.4% of these cases, with a slightly higher prevalence in NT2 (30%) than in NT1 (24%). REM-OSA showed a trend toward higher prevalence in the narcolepsy group compared to controls (26.4% vs 17.2%, OR: 1.73, 95% CI: 0.91-3.27, p = 0.09). Male sex, BMI, and arousal index were independent correlates of OSA among patients with narcolepsy. REM-OSA was independently associated with arousal index and REM sleep duration. OSA and REM-OSA are common in patients with narcolepsy. REM-OSA was more prevalent in the narcolepsy group than in matched controls, suggesting a potential association between narcolepsy and REM-OSA that warrants investigation in larger cohorts.