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Background: The benefits of social support are often overlooked in common management components of cardiovascular diseases. The Multidimensional Scale of Perceived Social Support (MSPSS) is self-administered and scores perceived social support (PSS). We sought to identify PSS among cardiovascular patients and the effects it may have on quality of life (QoL) and treatment compliance. Methods: A total of 96 patients were evaluated using the MSPSS in 3 categories: significant other (SO), family, and friends using a 7-point Likert scale. A supplemental lifestyle survey assessed various demographics, subjective QoL, and compliance with treatment plans. Results: Patients with high QoL reported a higher PSS Likert score in the family support category. Patients who were compliant with appointments and had high substance use avoidance (tobacco, alcohol, illicit drugs) had a higher PSS Likert score in the friend support and higher PSS Likert score in support from SO and family categories, respectively. No difference in PSS was found in compliance with medications, diet, and exercise. Conclusion: Various social support categories are directly associated with higher QoL, adherence to appointments, and substance abuse avoidance.

Polyamines are positively-charged organic molecules that are important for cellular growth and division. Polyamines and their synthesizing enzymes are particularly abundant in rapidly proliferating eukaryotic cells such as parasitic protozoa and cancer cells. Polyamine biosynthesis inhibitors, such as Elfornithine, are now being considered for cancer prevention and have been used effectively against Trypanosoma brucei. Inhibitors of polyamine biosynthesis have caused growth arrest of Plasmodium falciparum blood stages in vitro, but in P. berghei only partial inhibition has been observed. While polyamine biosynthesis enzymes are characterized and conserved in Plasmodium spp., little is known on the biological roles of these enzymes inside malaria parasite hosts. The bifunctional polyamine biosynthesis enzyme S-adenosyl methionine decarboxylase/ornithine decarboxylase (AdoMetDC/ODC) was targeted for deletion in P. yoelii. Deletion of AdoMetDC/ODC significantly reduced blood stage parasitemia but Anopheles transmission was completely blocked. We showed that male gametocytogenesis and male gamete exflagellation were abolished and consequently no ookinetes or oocyst sporozoites could be generated from adometdc/odc(–) parasites. Supplementation of putrescine and spermidine did not rescue the defective phenotypes of male gametocytes and gametes of the knockout parasites. These results highlight the crucial role of polyamine homeostasis in the development and functions of Plasmodium erythrocytic stages in the blood and in the mosquito vector and validate polyamine biosynthesis pathway enzymes as drug targeting candidates for malaria parasite transmission blocking.

OBJECTIVE:Exposure to environmental tobacco smoke (ETS) in smoky venues puts patrons and employees at risk for immediate respiratory symptoms. Although much literature focuses on outcomes associated with chronic ETS exposure, the current study assesses changes in lung function after acute exposure. METHODS:Ninety-six nonsmoking, healthy adults were exposed to ETS at a bar. Lung function [eg, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1)] was assessed at baseline, immediately after 3 hours of ETS exposure, and 2 hours after exiting the bar. PM2.5 recordings were also measured. RESULTS:Repeated-measures analysis of variance found significant decreases in FEV1, FVC and FEF25–75%, and peak expiratory flow after ETS exposure compared with baseline that remained significantly decreased after a 2-hour recovery period. CONCLUSIONS:Acute exposure to ETS in a natural environment significantly attenuates lung function. A subgroup experienced heightened reductions in lung function.

Present study assessed the growth of two plant species and ion uptake by them grown on different proportion of industrial solid waste and garden soil. The industrial waste having high concentration of chemicals were used with garden soil at different proportion i.e. 0% (T0), 5% (T1), 10% (T2), 15% (T3) and 20% (T4). Two species namely Conocarpus erectus (alien plant) and Dodonaea viscosa (indigenous) were used as test plants in pot study. Different parameters including growth, physiology, and anatomy of plants and concentration of cations (Na + , K + , Ca 2+ , and Mg 2+ ) in the plant shoot and root were measured at different time duration (initial, 1 st , 2 nd , 3 rd and 4 th month). The key objective of the study was to use these plants to establish their plantations on the barren lands where industrial solid wastes were being disposed of. C . erectus showed better growth than D. viscosa, as well as more uptake of ions. A significant increase in plant growth was observed in fourth month in T1, where plant height reached 24.5% and 46% for C . erectus and D. viscosa , respectively. At harvest, in C. erectus , no significant difference in the fresh (65–78 g) and dry weight (24–30 g) of the shoot was observed across treatments compared to the control. In D. viscosa , at the time of harvest, the fresh and dry weights of the root and shoot showed a strong, significantly decreasing pattern across T1, T2, and T3, leading to the death of the plant at T3 and T4. Further, optimum ratio of waste soil to garden soil was found as 10:90 and 20:80 to establish the plantations of D. viscosa and C. erectus , respectively in areas where such solid waste from industries are disposed. Findings can be used for the restoration of such solid waste for the sustainable management of industrial areas and their associated ecosystems.

Urban mobility in the Global South presents unique challenges for public transport (PT) and emerging shared mobility (SM) services influenced by socio-economic factors, mobility attitudes, and urban form. This study examines the factors shaping mode choice behavior between PT and SM services in four communities each in Dubai and Lahore. Additionally, it analyses the impact of primary daily activities on PT and SM preferences in both cities. Data from 1,653 Dubai and 1,603 Lahore residents were analyzed using four binary logistic regression models. Results indicate that socio-demographic factors (age, gender, household car ownership, driver's license possession, education level, and weekly commuting trips) and mobility attitudes (ride-sharing, ride-hailing, pro-personal car) significantly influence PT and SM choices. Key determinants vary by neighborhood type, including link-node ratio, intersection and road length density, and car and PT commute times. The influence of primary daily activities (work or study) on the choice of PT and SM modes was found to be moderate in Dubai. The study highlights the need for tailored urban and transport policies to promote sustainable modes, considering neighborhood characteristics and demographics.

The degraded water quality of recreational beaches and associated diseases is a global concern. The discharge of municipal effluents and other wastes has threatened coastal resources irrespective of local authorities colossal investment in their development. Strategic assessment and monitoring of water quality are essential pathways to reduce contaminant level of microbes responsible for waterborne diseases. As in Karachi’s case study, two wastewater discharge drains were identified at Sea View, which is famous for recreational activities. These two primary discharge drains contained contaminants, including various pathogens that pollute the marine environment and disturb the ecosystem. The current study aims to assess the water quality along the beach through an in-depth monitoring program lasting from May till September 2020. The assessment focused on total coliform (TC) and faecal coliform (FC) counts; biochemical oxygen demand (BOD₅) and chemical oxygen demand (COD). Analysis of the results conclude that both discharge drains contained high levels of TC (1600 MPN or CFU per 100 mL of the sample) and FC (203 MPN per 100 mL). Moreover, COD and BOD levels were found to be high (COD 945 mg/L and BOD 410 mg/L). Hence, recreational activity may not be suitable near these discharge drains, indicating their association with high health risks.

The white mango scale (WMS) insect, Aulacaspis tubercularis (Hemiptera: Diaspididae), is a polyphagous, multivoltine pest which is a serious threat to qualitative mango production and export. The WMS insect sucks sap from leaves, branches and fruits. The heavy infestation of this pest may cause the falling of young leaves, drying up of twigs, poor flowering, and, finally, reduce the quality of fruits by producing pink spots on fruits’ surface. This review paper was written to provide comprehensive information about pest biology, ecology and management in different parts of the world. WMS was first reported on the island of Formosa on Mangifera indica in 1929 and later on in the Caribbean Islands, India and Brazil. Now it is found in almost 69 mango-producing countries of the world. The thermal regime may affect the population of pests. In Australia, the life cycle is completed in 35–40 days in summer and 70–85 days in winter. Variety, age of plants, number of trees per acre, canopy size and sunlight penetration affect the density of WMS. Different Coccinellid beetles and parasitoid Encarsia femorosa feed on WMS; however, farmers most commonly use insecticides to get rid of this pest. In Pakistan, WMS is a growing threat to the export of mangoes; hence IPM plan is needed to reduce the pest numbers and enhance qualitative mango production.