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2 result(s) for "Gleason, Trevis"
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Overcoming barriers in progressive multiple sclerosis research
Overcoming barriers in progressive multiple sclerosis research
by Zaratin, Paola , Gleason, Trevis L , Coetzee, Timothy in Alliances , Biomedical Research - trends , Clinical trials
2015
[...]innovations could take several forms, including consideration of new outcome measures, adaptive clinical trial designs, and consideration of surrogate markers. [...]enhanced engagement of patients with progressive multiple sclerosis by regulatory authorities could ensure that their views are fully incorporated into the regulatory processes.
Journal Article
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Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
by Fox, Robert J , Krieger, Stephen , Narayanan, Sridar in 3',5'-Cyclic-nucleotide phosphodiesterase , Adult , Atrophy
2018
The antiinflammatory small molecule ibudilast was tested in a phase 2 trial in patients with progressive multiple sclerosis. The rate of brain atrophy over 96 weeks was lower with ibudilast than with placebo. Side effects with ibudilast included GI symptoms and depression.
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