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Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

by Fox, Robert J , Krieger, Stephen , Narayanan, Sridar , Alvarez, Enrique , Lowe, Mark J , Coyle, Patricia K , Zhou, Xiaopeng , Apperson, Michelle , Bashir, Khurram , Gleason, Trevis , Bermel, Robert A , Jagodnik, Patricia , Jubelt, Burk , Severson, Christopher , Lava, Neil , Suski, Valerie , Barnes, Janel , Koepp, Maxine , Cohen, Bruce A , Zabeti, Aram , Dewitt, L. Dana , Sakaie, Ken E , Giesser, Barbara S , Goodman, Andrew , Moses, Harold , Thoomukuntla, Bhaskar , Repovic, Pavle , Cudkowicz, Merit E , Nakamura, Kunio , Perumal, Jai S , Lynch, Sharon G , Matsuda, Kazuko , Shinnar, Shlomo , McGovern, Michelle , Naismith, Robert T , Yadav, Vijayshree , Natarajan, Sneha , Riley, Claire S , Thornell, Brenda , Ashokkumar, Akshata , Long, Jeffrey D , Ecklund, Dixie , Weinstock-Guttman, Bianca , Yankey, Jon , Debbins, Josef P , Huang, Xuemei , Racke, Michael , Klawiter, Eric C , Flores, Angela , Conwit, Robin , Klingner, Elizabeth , Goldman, Myla D , Delgado, Silvia , Coffey, Christopher S , Ontaneda, Daniel

in 3',5'-Cyclic-nucleotide phosphodiesterase / Adult / Atrophy / Atrophy - prevention & control / Brain - diagnostic imaging / Brain - pathology / Cortex / Depression - chemically induced / Diffusion Tensor Imaging / Disease Progression / Double-Blind Method / Drug dosages / Female / Gastrointestinal Diseases - chemically induced / Headache / Headache - chemically induced / Humans / Leukocyte migration / Macrophage migration inhibitory factor / Magnetic resonance imaging / Male / Mental depression / Middle Aged / Multiple sclerosis / Multiple Sclerosis, Chronic Progressive - drug therapy / Multiple Sclerosis, Chronic Progressive - pathology / Nervous system / Neuroimaging / Neurological diseases / Neurological disorders / NMR / Nuclear magnetic resonance / Phosphodiesterase Inhibitors - adverse effects / Phosphodiesterase Inhibitors - therapeutic use / Pyramidal tracts / Pyridines - adverse effects / Pyridines - therapeutic use / Retina / TLR4 protein / Toll-like receptors / Vertigo

2018

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2018

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2018

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Journal Article

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Fox, Robert J,

Krieger, Stephen,

Narayanan, Sridar,

Alvarez, Enrique,

Lowe, Mark J,

Coyle, Patricia K,

Zhou, Xiaopeng,

Apperson, Michelle,

Bashir, Khurram,

Gleason, Trevis,

Bermel, Robert A,

Jagodnik, Patricia,

Jubelt, Burk,

Severson, Christopher,

Lava, Neil,

Suski, Valerie,

Barnes, Janel,

Koepp, Maxine,

Cohen, Bruce A,

Zabeti, Aram,

Dewitt, L. Dana,

Sakaie, Ken E,

Giesser, Barbara S,

Goodman, Andrew,

Moses, Harold,

Thoomukuntla, Bhaskar,

Repovic, Pavle,

Cudkowicz, Merit E,

Nakamura, Kunio,

Perumal, Jai S,

Lynch, Sharon G,

Matsuda, Kazuko,

Shinnar, Shlomo,

McGovern, Michelle,

Naismith, Robert T,

Yadav, Vijayshree,

Natarajan, Sneha,

Riley, Claire S,

Thornell, Brenda,

Ashokkumar, Akshata,

Long, Jeffrey D,

Ecklund, Dixie,

Weinstock-Guttman, Bianca,

Yankey, Jon,

Debbins, Josef P,

Huang, Xuemei,

Racke, Michael,

Klawiter, Eric C,

Flores, Angela,

Conwit, Robin,

Klingner, Elizabeth,

Goldman, Myla D,

Delgado, Silvia,

Coffey, Christopher S,

Ontaneda, Daniel

2018

Overview

The antiinflammatory small molecule ibudilast was tested in a phase 2 trial in patients with progressive multiple sclerosis. The rate of brain atrophy over 96 weeks was lower with ibudilast than with placebo. Side effects with ibudilast included GI symptoms and depression.

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Publisher

Massachusetts Medical Society

Subject

3',5'-Cyclic-nucleotide phosphodiesterase

/ Adult

/ Atrophy

/ Atrophy - prevention & control

/ Brain - diagnostic imaging

/ Brain - pathology

/ Cortex