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"Gupta, Ravi Kumar"
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Building Scalable Web Apps with Node. js and Express
Embark on a journey to become an expert in backend web development with this essential guide using Node.js v20, Express.js, Redis and TypeScript.The book covers foundational to advanced topics through one comprehensive example: a project management system. It ensures learning and application of skills in API caching with Redis, API testing using Mocha and Chai, and deployment on AWS. This approach simplifies complex concepts and provides a practical learning trajectory.With expert tips and best practices, you'll create user-friendly features like sign-ups and project trackers. Plus, you'll learn how to make your apps faster with caching and add cool features like notifications. Finally, you'll ace testing and deploying your apps like an expert.
eBook
Mathematical modeling for intelligent systems : theory, methods, and simulation
\"Mathematical Modeling for Intelligent Systems: Theory, Methods and Simulation aims to provide a reference for the applications of mathematical modeling using intelligent techniques in various unique industry problems in the era of Industry 4.0. Providing a thorough introduction to the field of soft computing techniques, the book covers every major technique in artificial intelligence in a clear and practical style. It also highlights current research and applications, addresses issues encountered in the development of applied systems, and describes a wide range of intelligent systems techniques, including neural networks, fuzzy logic, evolutionary strategy, and genetic algorithms. The book demonstrates concepts through simulation examples and practical experimental results. The book offers a well-balanced mathematical analysis of modelling physical systems. Summarizes basic principles in differential geometry and convex analysis as needed. The book covers a wide range of industrial and social applications, and bridges the gap between core theory and costly experiments through simulations and modelling. The focus of the book is manifold ranging from stability of fluid flows, nano fluids, drug delivery, and security of image data to Pandemic modeling etc. The book is primarily aimed at advanced undergraduates and postgraduate students studying computer science, mathematics and statistics. Researchers and professionals will also find this book useful\"-- Provided by publisher.
BOOK
Systemic Therapy De-Escalation in Early-Stage Triple-Negative Breast Cancer: Dawn of a New Era?
Early-stage triple negative breast cancer (TNBC) has been traditionally treated with surgery, radiation, and chemotherapy. The current standard of care systemic treatment of early-stage II and III TNBC involves the use of anthracycline-cyclophosphamide and carboplatin-paclitaxel with pembrolizumab in the neoadjuvant setting followed by adjuvant pembrolizumab per KEYNOTE-522. It is increasingly clear that not all patients with early-stage TNBC need this intensive treatment, thus paving the way for exploring opportunities for regimen de-escalation in selected subgroups. For T1a tumors (≤5 mm), chemotherapy is not used, and for tumors 6–10 mm (T1b) in size with negative lymph nodes, retrospective studies have failed to show a significant benefit with chemotherapy. In low-risk patients, anthracycline-free chemotherapy may be as effective as conventional therapy, as shown in some studies where replacing anthracyclines with carboplatin has shown non-inferior results for pathological complete response (pCR), which may form the backbone of future combination therapies. Recent advances in our understanding of TNBC heterogeneity, mutations, and surrogate markers of response such as pCR have enabled the development of multiple treatment options in the (neo)adjuvant setting in order to de-escalate treatment. These de-escalation studies based on tumor mutational status, such as using Poly ADP-ribose polymerase inhibitors (PARPi) in patients with BRCA mutations, and new immunotherapies such as PD1 blockade, have shown a promising impact on pCR. In addition, the investigational use of (bio)markers, such as high levels of tumor-infiltrating lymphocytes (TILs), low levels of tumor-associated macrophages (TAMs), and complete remission on imaging, also look promising. In this review, we cover the current standard of care systemic treatment of early TNBC and review the opportunities for treatment de-escalation based on clinical risk factors, biomarkers, mutational status, and molecular subtype.
Journal Article
Surface Engineering of Titanium Using Anodization and Plasma Treatment
Ti64 alloy is a well-known material for biomedical applications due to high corrosion resistance and biocompatibility properties. Surface properties of implants plays a vital role in bone and cell growth in the human body. With the anodization process, we can increase the surface porosity, which will be adequate for surface fascination of the implant screw to the bone and appropriate mechanical properties. Hence, the present study attempted to improve the surface properties of Ti64 by anodization and plasma treatment that may be promising method to increase the biocompatibility of Ti materials. Anodization process is the cheapest one to improve the surface properties of Ti alloy and riskless process. To intensify the open pores on the Ti64 surface plasma treatment was performed. Also, the aim of this study was to improve the aesthetic appearance of the dental implants and reproduce interference of colours. With the help of UV-VIS spectrophotometer the colour and spectral reflectance were investigated. The oxide layer thickness, chemical composition and nanosurface roughness was measured. These results suggests the surface modification of Ti64 alloy by anodization can produce interference of colours and are dependent on the applied voltage, oxide layer thickness. The surface oxidation consisting of anatase and rutile phase and change in nanosurface roughness, may improve the biocompatibility of Ti64.
Journal Article
An Empirical Analysis of the Effects of Energy Price Shocks for Sustainable Energy on the Macro-Economy of South Asian Countries
Energy prices (EPs) play an imperative role in South Asian Country (SAC) Gross Domestic Product (GDP). This research empirically examines the influence of sustainable energy price shocks (EPSs) on macroeconomic indicators. The study is to forecast the impact of EPS on macroeconomic indicators from 1980 to 2020. The analysis is carried out by employing the Vector Auto-Regression (VAR) approach. Impulse Response Functions (IRFs) results indicate that EPS decreases Gross Domestic Product (GDP). They exist in the short run and the long run. This research study’s overall findings suggest that high EPSs have a negative impact on GDP. The study implies that policymakers should develop, adopt, and initiate some imperatives to control the unanticipated volatility and movements in EP. The study highlights that policy should be designed to prevent fluctuations in sustainable EP and plan conservative energy policies that motivate discovering alternative energy sources to meet increasing energy demand and improve economic growth.
Journal Article
Maximization of injected power and efficiency based optimal location of DPFC using iterative procedure
Among the FACTS device, the distributed power flow controller (DPFC) is a superior device. This can be evaluated after eliminating the dc capacitor between shunt and series convertors of the unified power flow controller (UPFC) and placing a number of low rating single phase type distributed series convertors in the line instant of using single large rating three phase series convertors as in the UPFC. The power flow through this dc capacitor as in the UPFC now takes place through the transmission line at a third harmonic frequency in the DPFC. The DPFC uses the D-FACTS that allows the replacement of a large three-phase converter as in the UPFC by several small-size series convertors present in the DPFC. The redundancy of several series convertors increases the system’s reliability of the power system. Also, there is no requirement for high voltage isolation as series convertors of the DPFC are hanging as well as single-phase types. Consequently, the DPFC system has a lower cost than the UPFC system. In this paper, the equivalent ABCD parameters of the latest FACTSdeviceDPFChave been formulated with the help of an equivalent circuit model of the DPFC at the fundamental frequency component. Further, the optimal location in the transmission line and maximum efficiency of the DPFC along with Thyristor Controlled Series Compensator (TCSC), Static Synchronous Shunt Compensator (STATCOM) and UPFC FACTS devices have been investigated using an iteration program developed in MATLAB under steady-state conditions. The results obtained depict that the DPFC when placed slightly off-center at 0.33 fraction distance from the sending end comes up with higher performance. Whereas, when the TCSC, STATCOM and UPFC are placed at 0.16, 0.2815, 0.32 fraction distances from sending end respectively give their best performance.
Journal Article
Correlation of Molecular Markers, Pfmdr1-N86Y and Pfcrt-K76T, with In Vitro Chloroquine Resistant Plasmodium falciparum, Isolated in the Malaria Endemic States of Assam and Arunachal Pradesh, Northeast India
The mechanism of chloroquine (CQ) resistance in Plasmodium falciparum is not clearly understood. However, CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1. These genes encode for digestive vacuole transmembrane proteins Pfcrt and Pgh1, respectively. The present study was carried out to analyze the association of Pfcrt-K76T and Pfmdr1-N86Y mutations with CQ resistance in Northeast Indian P. falciparum isolates. 115 P. falciparum isolates were subjected to in vitro CQ sensitivity testing and PCR-RFLP analysis for the Pfmdr1-N86Y and Pfcrt-K76T mutations. 100 isolates of P. falciparum were found to be resistant to CQ by the in vitro susceptibility test (geometric mean EC50 2.21 µM/L blood) while 15 were found to be CQ sensitive (geometric mean EC50 0.32 µM/L blood). All the CQ resistant isolates showed the presence of Pfmdr1 and Pfcrt mutations. CQ sensitive isolates were negative for these mutations. Strong linkage disequilibrium was observed between the alleles at these two loci (Pfmdr1-N86Y and Pfcrt-K76T). The results indicate that Pfmdr1-N86Y and Pfcrt-K76T mutations can be used as molecular markers to identify CQ resistance in P. falciparum. The result necessitates the evaluation of CQ in vivo therapeutic efficacy in endemic areas for more effective malaria control strategies.
Journal Article
Acyl Homoserine Lactones from Culture Supernatants of Pseudomonas aeruginosa Accelerate Host Immunomodulation
The virulence of Pseudomonas aeruginosa is multifactorial and under the control of quorum sensing signals, such as acyl homoserine lactones (AHLs). The importance of these molecules in the establishment of infection has been previously reported. These molecules either improve the virulence potential of P. aeruginosa or modulate the host immune response. To establish the immune modulating potential of quorum sensing signal molecules, previous studies have only used synthetic AHLs. However, there can be differences in the biological properties of synthetic and natural AHLs. The use of naturally extracted AHLs from the culture supernatant of P. aeruginosa is likely to simulate natural conditions more than the use of synthetic AHLs. Therefore, in the present study, the immune modulating potential of synthetic and naturally extracted AHLs was compared using a thymidine uptake assay, immunophenotyping and sandwich ELISA in order to assess mouse T-cell proliferation and production of Th1 and Th2 cytokines. Natural AHLs were able to suppress T-cell proliferation, even at low concentrations, compared to synthetic AHLs. The majority of cells undergoing proliferation were CD4+, as revealed by immunophenotyping. The inhibition of T-cells was stronger with natural AHLs compared to synthetic AHLs. Moreover, the natural AHLs were also able to shift immune responses away from host protective Th1 responses to pathogen protective Th2 responses.
Journal Article
Telerobot: Failure Detection Using Imaging Technique for Piping Internal Surfaces
Pipelines are the energy lifelines of almost every activity of everyday life. It is a safe way of transporting water, gas and oil over long distances. It is also the most practical way to deliver oil and gas across countries as being an extremely safe and economically viable solution to transport energy. Cracking and corrosion on the external and/or internal surfaces of in-service pipes, reduces the integrity of the material and potentially reduces the service life of the transportation system and equipment. Defects in pipelines may have various forms and may be initiated by one or more mechanisms potentially resulting in corrosion and/or cracking. In this paper we propose a system that detects the internal cracks in pipelines through a telerobot which can be inserted into the pipelines and detects the internal Failures (cracks) through a special modern high resolution digital camera and image processing techniques. The telerobot is a programmable and can be controlled as per the requirements such as speed and direction of the telerobot and sensors using mobile application and can be connected to a computer and smart phone. The telerobot captures a high definition images and also captures the precise location. These images are transferred to a computing facility for the analyses and to detect cracks.
Journal Article