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BackgroundDiabetic nephropathy (DN) is a frequent and long-lasting microvascular consequence that has an established connection with diabetes. It serves as the primary etiological agent of end-stage renal disease, a critical renal disorder that develops on a worldwide level. The molecular pathophysiology of DN is multifactorial, such as transforming growth factor-beta [TGF-β] which affects the expression of miRNAs such as miRNA-21 and miRNA-192 during renal fibrosis. However, to date, the clinical application is inadequate due to discrepancies observed in the published data. This cross-sectional investigation aimed to assess the correlation between serum TGF-β1, miRNA-21 and 192, and glycemic control, metabolic abnormalities, and renal function in patients with type II diabetes.MethodsBased on the albumin/creatinine ratio (ACR), fifty subjects with type II diabetes were divided into three categories: Group I consisted of individuals with normoalbuminuria (n = 16), Group II of microalbuminuria (n = 16), and Group III of overt proteinuria (n = 18). All participants were subjected to the estimation of mature miRNA-21 and miRNA-192 by TaqMan two-step stem loop qRT-PCR and serum TGFβ1 level by ELISA.ResultsThere was an upregulation in miRNA-21 expression in the 3 different groups of patients (p value = 0.043). The serum fold change (FC) of miRNA-21 showed significantly greater median values in patients with overt proteinuria compared to those with normoalbuminuria (5.57 FC versus 1.11 FC, p = 0.017). A positive correlation (r = 0.343) (p = 0.013) was observed between the ACR and the median levels of miRNA-21, which was statistically significant. No statistically significant distinctions were detected in the concentrations of serum TGF-β1 or miRNA-192 among the three patient groups (p values of 0.234 and 0.225, respectively).ConclusionThe findings of the present research implied that miRNA-21 might function as an early indicator of renal pathology associated with diabetes mellitus (DM).

Zinc (Zn) is a vital trace element that plays a pivotal role in protein synthesis, cellular growth, and differentiation and is involved as a cofactor of metalloenzymes, performing a wide variety of metabolic, immune, and synthesis roles. Zn is required at all stages of an infant’s and child’s development, and severe Zn deficiency has been reported to lead to slower physical, cognitive, and sexual growth. Preterm neonates are at a higher risk of developing zinc deficiency for a variety of reasons, including low Zn intake from enteral feeds containing breast milk, relative malabsorption due to immaturity of the gastrointestinal tract with limited absorptive capacity, increased urinary loss of zinc, and increased demand during the early developmental stages. Moreover, premature infants are at risk of gastrointestinal diseases like necrotizing enterocolitis (NEC), which can limit absorption capacity and potentially lead to malabsorption. TPN is frequently used in preterm infants to provide them with sufficient nutrients and calories. However, it has its own complications, including cholestasis, especially if used for prolonged periods. In this case report, we are presenting the case of a male preterm infant who was delivered by caesarean section at 26 weeks’ gestation. The baby developed an intestinal perforation due to NEC, for which he underwent surgery for resection of the necrotic bowel and the creation of a high ileal stoma and was put on prolonged total parenteral nutrition (TPN), which led to the development of zinc deficiency.

Background: Endometrial cancer (EC) is the sixth most common cancer among women globally, with an estimated 420,000 new cases diagnosed annually. Methods: This study comprised patients with endometrial cancer (EC) (n = 17), hyperplasia (HY) (n = 17), and controls (CO) (n = 20). Tissue was collected from the endometrium of all 54 patients, including patients with HY, EC, and CO, who underwent total hysterectomy. EC and HY diagnoses were confirmed based on histological examination. Untargeted metabolomics profiling was conducted using LC-HRMS. The partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models were used for univariate and multivariate statistical analysis. The fitness of the model (R2Y) and predictive ability (Q2) were used to create OPLS-DA models. ROC analysis was carried out, followed by network analysis using Ingenuity Pathway Analysis. Results: The top metabolites that can discriminate EC and HY from CO were identified. This revealed a decrease in the levels of the lipid species, specifically phosphatidic acid (PA) (PA (14:1/14:0), PA(10:0/17:0), PA(18:1-O(12,13)/12:0)), PG(a-13:0/a-13:0), ganglioside GA1 (d18:1/18:1), PS(14:1/14:0), TG(20:0/18:4/14:1), and CDP-DG(PGF2alpha/18:2), while the levels of 3-Dehydro-L-gulonate, Uridine diphosphate-N-acetylglucosamine, ganglioside GT2 (d18:1/14:0), gamma-glutamyl glutamic acid and oxidized glutathione were increased in cases of EC and HY as compared to CO. Bioinformatics analysis, specifically using Ingenuity Pathway Analysis (IPA), revealed distinct pathway enrichments for EC and HY. For EC, the most highly scored pathways were associated with cell-to-cell signaling and interaction, skeletal and muscular system development and function, and small-molecule biochemistry. In contrast, HY cases showed the highest scoring pathways related to inflammatory disease, inflammatory response, and organismal injury and abnormalities. Conclusions: Developing sensitive biomarkers could improve diagnosis and guide treatment decisions, particularly in identifying which patients with HY may safely avoid hysterectomy and be managed with hormonal therapy.

Objectives. Post exposure prophylaxis (PEP) with the hepatitis B vaccine (HBVac) in combination with HBV immunoglobulins (HBIG) significantly minimizes the odds of vertical transmission of HBV to newborn infants. In this retrospective study, we aimed to evaluate the compliance and efficacy of PEP in a tertiary care center in Saudi Arabia. Methods. Infants were tested with HBV serological markers at 7 months of age to assess their PEP protection rate. Results. Out of 13,125 mothers who delivered in KAMC, 105 (0.8%) mothers were found to have HBsAg positive, with a prevalence of 8 per 1000 live births. All infants (n = 100) completed their PEP as per protocol before discharge from the hospital (2 days after delivery). Among infants (n = 59; 56.2%) who were tested at 7 months of age, all (100%) were found to be negative for HBV. Conclusion. PEP achieved 100% efficacy among infants who complied with the study protocol at 7 months of follow-up. The prevalence of hepatitis B among pregnant women was 8 per 1000 live births.

Diabetic nephropathy (DN) is a frequent and long-lasting microvascular consequence that has an established connection with diabetes. It serves as the primary etiological agent of end-stage renal disease, a critical renal disorder that develops on a worldwide level. The molecular pathophysiology of DN is multifactorial, such as transforming growth factor-beta [TGF-] which affects the expression of miRNAs such as miRNA-21 and miRNA-192 during renal fibrosis. However, to date, the clinical application is inadequate due to discrepancies observed in the published data. This cross-sectional investigation aimed to assess the correlation between serum TGF-1, miRNA-21 and 192, and glycemic control, metabolic abnormalities, and renal function in patients with type II diabetes. Based on the albumin/creatinine ratio (ACR), fifty subjects with type II diabetes were divided into three categories: Group I consisted of individuals with normoalbuminuria (n = 16), Group II of microalbuminuria (n = 16), and Group III of overt proteinuria (n = 18). All participants were subjected to the estimation of mature miRNA-21 and miRNA-192 by TaqMan two-step stem loop qRT-PCR and serum TGF1 level by ELISA. There was an upregulation in miRNA-21 expression in the 3 different groups of patients (p value = 0.043). The serum fold change (FC) of miRNA-21 showed significantly greater median values in patients with overt proteinuria compared to those with normoalbuminuria (5.57 FC versus 1.11 FC, p = 0.017). A positive correlation (r = 0.343) (p = 0.013) was observed between the ACR and the median levels of miRNA-21, which was statistically significant. No statistically significant distinctions were detected in the concentrations of serum TGF-1 or miRNA-192 among the three patient groups (p values of 0.234 and 0.225, respectively). The findings of the present research implied that miRNA-21 might function as an early indicator of renal pathology associated with diabetes mellitus (DM).

In this thesis, we propose a stimulus-responsive paradigm which integrates electromagnetic (EM) and molecular communication (MC) by stimulating proteins in the human body. Our model, which consists of a nanoantenna transmitter (Tx) and a protein receiver (Rx), capitalizes on the fact that proteins act as an interface between both mediums, in which triggering proteins by THz waves changes their conformational structure.In the first part of the thesis, we adopt a Markov chain model to account for the protein stochasticity with transition rates governed by the nanoantenna force. Both two-state and multi-state protein models are presented to depict different biological configurations. A closed form expression for the mutual information of each scenario is derived and maximized to find the capacity between the input force and the protein state.In the second part of the thesis, we formulate a selectivity metric for both single and multiple proteins. The metric serves as an indicator that quantifies the system performance. It provides a score between −1 and 1 to capture the capability of the nanoantenna in stimulating a conformational change in the desired protein population, without provoking untargeted proteins to fold.In the third part of the thesis, we study the impact of the intra-body environment on the THz induced protein interactions. Specifically, we consider the channel between the Tx and Rx to be a blood vessel composed of moving red blood cells (RBCs). The cells act as obstacles that attenuate the signal power, giving rise to both shadowing and fading. We thereby investigate the effect of the medium’s stochastic nature on the previously developed selectivity metric to evaluate the nanoantenna-protein interaction.In the final part of the thesis, we study the thermal effect of THz radiation on protein networks, particularly under resonant conditions. To do so, we adopt the heat diffusion model, where we conduct a parametric study explaining the impact of the signal power, pulse duration, and inter-particle distance on the protein thermal analysis. Finally, we demonstrate the relationship between the change in temperature and the opening probability of thermally-gated ion channels.

Responses to a polar question have recently received much attention in the syntactic literature (e.g., Yaisomanag, 2012 on Thi; Wu, 2016 on Taiwanese, Servidio et al., 2018 on Italian; among others). However, the syntax of yes-no questions in Arabic has been undermined in the literature. The present study provides a syntactic analysis of answers to positive/neutral polar questions in Jordanian Arabic. Jordanian Arabic is particularly relevant here because its system allows for a variety of answer expressions. For example, an answer to a polar question could be in the form of a particle (a: 'yes' and la? 'No') or a finite verb echoing the verb of the question. Following Holmberg (2016), we demonstrate that these expressions are full sentences derived by ellipses. We assume that a yes-no question has an unvalued, free polarity variable [±Pol] that needs to be assigned a value. Deriving the answer would provide a value for this variable. This involves copying the TP of the question and merging an answer particle or an abstract polarity feature (affirmative or negative) in spec-Foc to value the unvalued feature of Pol; then the TP of the answer gets deleted at the PF component under identity with the TP of the question.

Evaluation for E-learning was and is still a problem for many educators and lecturers in universities and even schools in Palestine especially nowadays after COVID-19. Based on this fact, the current study aimed at diagnosing the validity of the E- learning assessment tools applied by the ministry of education in secondary schools and also developing new E- learning evaluation tools for assessing students' learning at the secondary schools in Palestine from teachers, supervisors and university lecturers' points of view. The research followed a descriptive analytic research method in order not only describing the problem under investigation, but also providing numerical data that identify the extent to which the sample agree on the items exposed. To achieve the aim of the study, the researcher distributed a questionnaire for surveying the points' of view of (40) teachers, supervisors regarding the E-learning evaluation tools applied lately in high schools in Palestine throughout the pandemic and then a semi structured interview conducted with (5) supervisors and university lecturers for giving solutions and suggestions concerning the best E- learning assessment tools that can be used for evaluating the E-learning process from their points of view. SPSS package was used to validate tools and analyze data. The results showed that only 59.6% believed that \"The ministry mechanism for E-learning was clear\". Moreover, only 15.9% agreed that this mechanism was efficient. In fact, the results showed that this mechanism encountered many obstacles during its implementation. It was found that only 21.7% agreed that \"E-learning evaluation mechanism was completely free from any obstacles during the implementation process.\" Based on the results, the researcher recommended the ministry of education to approve standardizing electronic exams and deciding about firm procedures to be used with those who are non-committed, make a deal with tele-communication companies to restrict the search ability via google throughout exams times, and connect students' emails with Rawafed G-suit in order not to allow students to join the exams with unreal emails. Also, teachers were recommended to prepare questions that measure the high level of thinking.

The engineering community is witnessing a new frontier in the communication industry. Among others, the tools provided by nanotechnologies enable the development of novel nanosensors and nanomachines. On the one hand, nanosensors are capable of detecting events with unprecedented accuracy. On the other hand, nanomachines are envisioned to accomplish tasks ranging from computing and data storing to sensing and actuation. Recently, in vivo wireless nanosensor networks (iWNSNs) have been presented to provide fast and accurate disease diagnosis and treatment. These networks are capable of operating inside the human body in real time and will be of great benefit for medical monitoring and medical implant communication. Despite the fact that nanodevice technology has been witnessing great advancements, enabling the communication among nanomachines is still a major challenge.