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Robert Edmund Jones, a pillar of stage design, once wrote a comment about design that summarizes my design drive upon entering graduate school, “Realism is something we practice when we aren't feeling very well. When we don't feel up to the extra effort”. In an effort to break the traditional mold many American scenic designers fall into, myself included, I choose to learn and grow from a European designer and Professor, Nic Ularu. His European based teaching principles of scenography have taught me to explore every option available and ignore initial instinct to create symmetry and structure. Through exploration, analysis, and visual arts my ability to become a influential scenographer will be forever strengthened.

Gerard Schellenberg and colleagues report a genome-wide association study of late-onset Alzheimer's disease (LOAD), as part of the Alzheimer Disease Genetics Consortium. They identify common variants in MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 associated with LOAD. The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P ( P M ) = 1.7 × 10 −9 , joint analysis P ( P J ) = 1.7 × 10 −9 ; stages 1, 2 and 3, P M = 8.2 × 10 −12 ), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 −9 ), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 −10 ) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 −9 ). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 −10 , P J = 5.2 × 10 −11 ), CLU (rs1532278; P M = 8.3 × 10 −8 , P J = 1.9 × 10 −8 ), BIN1 (rs7561528; P M = 4.0 × 10 −14 , P J = 5.2 × 10 −14 ) and PICALM (rs561655; P M = 7.0 × 10 −11 , P J = 1.0 × 10 −10 ), but not at EXOC3L2 , to late-onset Alzheimer's disease susceptibility 1 , 2 , 3 .