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(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image).The GERmanium Detector Array (Gerda) at the Gran Sasso Underground Laboratory (LNGS) searches for the neutrinoless double beta decay (...) of ...Ge. Germanium detectors made of material with an enriched ...Ge fraction act simultaneously as sources and detectors for this decay. During Phase I of theexperiment mainly refurbished semi-coaxial Ge detectors from former experiments were used. For the upcoming Phase II, 30 new ...Ge enriched detectors of broad energy germanium (BEGe)-type were produced. A subgroup of these detectors has already been deployed in Gerda during Phase I. The present paper reviews the complete production chain of these BEGe detectors including isotopic enrichment, purification, crystal growth and diode production. The efforts in optimizing the mass yield and in minimizing the exposure of the ...Ge enriched germanium to cosmic radiation during processing are described. Furthermore, characterization measurements in vacuum cryostats of the first subgroup of seven BEGe detectors and their long-term behavior in liquid argon are discussed. The detector performance fulfills the requirements needed for the physics goals of Gerda Phase II.

LArGe is a GERDA low-background test facility to study novel background suppression methods in a low-background environment, for future application in the GERDA experiment. Similar to GERDA, LArGe operates bare germanium detectors submersed into liquid argon (1 m3, 1.4tons), which in addition is instrumented with photomultipliers to detect argon scintillation light. The light is used in anti-coincidence with the germanium detectors to effectively suppress background events that deposit energy in the liquid argon. The background suppression efficiency was studied in combination with a pulse shape discrimination (PSD) technique using a BEGe detector for various sources, which represent characteristic backgrounds to GERDA. Suppression factors of a few times 103 have been achieved. First background data of LArGe with a coaxial HPGe detector (without PSD) yield a background index of the order 10−2 cts/(keV-kg-y), which is at the level of the GERDA phase I design goal. As a consequence of these results, the development of an active liquid argon veto in GERDA is pursued.

LArGe is a Gerda low-background test facility to study novel background suppression methods in a low-background environment, for future application in the Gerda experiment. Similar to Gerda, LArGe operates bare germanium detectors submersed into liquid argon (1 m , 1.4 tons), which in addition is instrumented with photomultipliers to detect argon scintillation light. The scintillation signals are used in anti-coincidence with the germanium detectors to effectively suppress background events that deposit energy in the liquid argon. The background suppression efficiency was studied in combination with a pulse shape discrimination (PSD) technique using a BEGe detector for various sources, which represent characteristic backgrounds to Gerda. Suppression factors of a few times have been achieved. First background data of LArGe with a coaxial HPGe detector (without PSD) yield a background index of (0.12 4.6) cts/(keV kg year) (90 % C.L.), which is at the level of Gerda Phase I. Furthermore, for the first time we monitor the natural Ar abundance (parallel to Gerda), and have indication for the -decay in natural germanium. These results show the effectivity of an active liquid argon veto in an ultra-low background environment. As a consequence, the implementation of a liquid argon veto in Gerda Phase II is pursued.

A discovery that neutrinos are Majorana fermions would have profound implications for particle physics and cosmology. The Majorana character of neutrinos would make possible the neutrinoless double-β (0νββ) decay, a matter-creating process without the balancing emission of antimatter. The GERDA Collaboration searches for the 0νββ decay of 76Ge by operating bare germanium detectors in an active liquid argon shield. With a total exposure of 82.4 kg·year, we observe no signal and derive a lower half-life limit of T 1/2 > 0.9 × 1026 years (90% C.L.). Our T 1/2 sensitivity, assuming no signal, is 1.1 × 1026 years. Combining the latter with those from other 0νββ decay searches yields a sensitivity to the effective Majorana neutrino mass of 0.07 to 0.16 electron volts.

Surgery and radiation are the mainstays of therapy for human gliomas that are the most common primary brain tumors. Most recently, cell culture and animal studies provided the first convincing evidence that radiation not only eliminates tumor cells, but also modulates the immune response and likely improves anti-tumor immunotherapy. We present an in vivo study that analyzes the effects of radiation on the immune response in tumor patients. As readout system, we utilized the reactivity of glioma patients' sera against antigen GLEA2 as the most frequent antigen immunogenic in glioblastoma patients. We established an ELISA assay to analyze reactivity of 24 glioblastoma patients over a period of several months. As control we used 30 sera from healthy donors as well as 30 sera from lung cancer patients. We compared the course of GLEA2 seroreactivity at different times prior, during and after radiation. The GLEA2 seroreactivity was increased by the time of surgery, decreased after surgery, increased again under radiation, and slightly decreased after radiation. Our results provide in vivo evidence for an increased antibody response against tumor antigens under radiation. Antigens that become immunogenic with an increased antibody response as result of radiation can serve as ideal targets for immunotherapy of human tumors.

Older men have the highest suicide rates worldwide, yet few interventions have been shown effective in reducing suicide risk in middle-age or older men (Lapierre et al., 2011). We developed and tested a novel, 12-session Meaning-Centered Men’s Group (MCMG) intervention with 100–120 cognitively-intact, community-residing men 55 years or older who were struggling to adjust to retirement, a transition associated for some with increased suicide risk. The intervention draws on research demonstrating negative associations of Meaning in Life (MIL) with depression and suicide ideation (Heisel & Flett, 2014, 2016), and aims to build camaraderie through group discussions about finding meaning in work, leisure, relationships, and generativity. This paper summarizes findings from this on-going study, including controlled analyses comparing MCMG with a current-events discussion group, and experiences disseminating MCMG to distant sites. Discussion will focus on helping men adjust meaningfully to retirement and preventing the onset or exacerbation of suicide ideation.

Many extensions of the Standard Model of particle physics explain the dominance of matter over antimatter in our Universe by neutrinos being their own antiparticles. This would imply the existence of neutrinoless double-β decay, which is an extremely rare lepton-number-violating radioactive decay process whose detection requires the utmost background suppression. Among the programmes that aim to detect this decay, the GERDA Collaboration is searching for neutrinoless double-β decay of Ge by operating bare detectors, made of germanium with an enriched Ge fraction, in liquid argon. After having completed Phase I of data taking, we have recently launched Phase II. Here we report that in GERDA Phase II we have achieved a background level of approximately 10 counts keV kg yr . This implies that the experiment is background-free, even when increasing the exposure up to design level. This is achieved by use of an active veto system, superior germanium detector energy resolution and improved background recognition of our new detectors. No signal of neutrinoless double-β decay was found when Phase I and Phase II data were combined, and we deduce a lower-limit half-life of 5.3 × 10 years at the 90 per cent confidence level. Our half-life sensitivity of 4.0 × 10 years is competitive with the best experiments that use a substantially larger isotope mass. The potential of an essentially background-free search for neutrinoless double-β decay will facilitate a larger germanium experiment with sensitivity levels that will bring us closer to clarifying whether neutrinos are their own antiparticles.

The Gerda collaboration is performing a sensitive search for neutrinoless double beta decay of 76Ge at the INFN Laboratori Nazionali del Gran Sasso, Italy. The upgrade of the Gerda experiment from Phase I to Phase II has been concluded in December 2015. The first Phase II data release shows that the goal to suppress the background by one order of magnitude compared to Phase I has been achieved. Gerda is thus the first experiment that will remain “background-free” up to its design exposure (100 kgyear). It will reach thereby a half-life sensitivity of more than 1026 year within 3 years of data collection. This paper describes in detail the modifications and improvements of the experimental setup for Phase II and discusses the performance of individual detector components.

Abstract Older adults have high rates of suicide and employ highly lethal means of self-harm (WHO, 2014). The aging of the population necessitates tools that quickly identify suicide risk and resiliency processes (Heisel & Duberstein, 2016). Linehan and colleagues (1983) initially identified Reasons for Living (RFL) as an adaptive psychological construct potentially preventive of suicide thoughts and behavior. Age-specific RFL scales have since been developed, including for older adults. The purpose of the present study was to develop and evaluate a brief version of the Reasons for Living Scale-Older Adults version (RFL-OA; Edelstein et al., 2009) for use in clinical and research contexts. A series of secondary analyses was conducted of a combined dataset (N=204) derived from three studies of late-life suicide ideation (Heisel & Flett, 2006; Heisel et al., 2015; Heisel, Neufeld, & Flett, 2016). We specifically assessed RFL-OA item distributions, and their contribution to internal consistency, construct validity, and social desirability. Thirty RFL-OA items were significantly associated with lifetime history of suicide attempt. Of these, 13 items were also associated with current suicide ideation. No item was highly correlated with social desirability. Findings supported the internal consistency, test-retest reliability, and construct and criterion validity of this abbreviated RFL scale. This study’s findings support the reliability and validity of a 13- item Reasons for Living-Suicide Risk scale (RFL-SR) for use with clinical and/or community-residing samples of older adults. These findings suggest promise for this abbreviated measure in assessing a psychological construct potentially protective against later-life suicide risk.

The GERmanium Detector Array (Gerda) is a low background experiment located at the Laboratori Nazionali del Gran Sasso in Italy, which searches for neutrinoless double-beta decay of \\[^{76}\\]Ge into \\[^{76}\\]Se+2e\\[^-\\]. Gerda has been conceived in two phases. Phase II, which started in December 2015, features several novelties including 30 new 76Ge enriched detectors. These were manufactured according to the Broad Energy Germanium (BEGe) detector design that has a better background discrimination capability and energy resolution compared to formerly widely-used types. Prior to their installation, the new BEGe detectors were mounted in vacuum cryostats and characterized in detail in the Hades underground laboratory in Belgium. This paper describes the properties and the overall performance of these detectors during operation in vacuum. The characterization campaign provided not only direct input for Gerda Phase II data collection and analyses, but also allowed to study detector phenomena, detector correlations as well as to test the accuracy of pulse shape simulation codes.