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"Husband, R"
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الزوج : رواية
هذه رواية \"الزوج The Husband\" للكاتب الأميركي \"دين كونتز Dean Koontz\" وهي الرواية التي احتلت المرتبة الأولى على قائمة \"نيويورك تايمز\" للكتب الأكثر مبيعا وكعادته في كل ما يكتب يدخلنا \"كونتز\" في عالم التشويق والغموض والترقب في آن معا، في رواية تحمل معنى الانتظار الذي لا يخلو من مسحة من رعب وعبر إيقاع سريع اعتمد أسلوب الفلاش باك يطرح \"كونتز\" في روايته هذه سؤالا هاما : ماذا تفعل لأجل الحب ؟ هل تموت من أجل الحب ؟ هل تقتل ؟ بعد ظهر يوم عادي يتلقى \"ميتش رافيرتي\" البستاني المفتون بجمال الطبيعة اتصالا هاتفيا شكل له أسوأ كابوس في حياته حيث بدا له أن المتصل جاد إلى أقصى الحدود ولكن لم يبال المتصل إن كان بوسع ميتش جمع هذا القدر من المال، إنه واثق بأنه سيجد طريقة ما، إذا كان يحب زوجته كفاية، وميتش يحب زوجته كثيرا، يحبها أكثر من الحياة نفسها، وهو يملك ستين ساعة فقط لإثبات ذلك، وعليه تأمين المليوني دولار قبل الوقت المحدد، لكنه مستعد ليدفع أكثر من ذلك بكثير، سيدفع أي شيء، من بدايتها إلى ذروتها المرهقة للأعصاب، تأخذك رواية الزوج في رحلة مثيرة تحبس الأنفاس عند كل منعطف، ومع كل صدمة، وعند كل بوح.
Book
Magnetic field screening in hydrogen-rich high-temperature superconductors
In the last few years, the superconducting transition temperature,
T
c
, of hydrogen-rich compounds has increased dramatically, and is now approaching room temperature. However, the pressures at which these materials are stable exceed one million atmospheres and limit the number of available experimental studies. Superconductivity in hydrides has been primarily explored by electrical transport measurements, whereas magnetic properties, one of the most important characteristic of a superconductor, have not been satisfactory defined. Here, we develop SQUID magnetometry under extreme high-pressure conditions and report characteristic superconducting parameters for
Im-3m
-H
3
S and
Fm-3m
-LaH
10
—the representative members of two families of high-temperature superconducting hydrides. We determine a lower critical field
H
c1
of ∼0.82 T and ∼0.55 T, and a London penetration depth
λ
L
of ∼20 nm and ∼30 nm in H
3
S and LaH
10
, respectively. The small values of
λ
L
indicate a high superfluid density in both hydrides. These compounds have the values of the Ginzburg-Landau parameter
κ
∼12–20 and belong to the group of “moderate” type II superconductors, rather than being hard superconductors as would be intuitively expected from their high
T
c
s.
Superconductivity in hydrides has been primarily explored by electrical transport measurements. Here, the authors perform SQUID magnetometry under extreme high-pressure and report characteristic superconducting parameters for
Im
-
3m
-H
3
S and
Fm
-
3m
- LaH
10
—the representative members of two families of high-temperature superconducting hydrides.
Journal Article
Toward an Operational Anthropogenic CO₂ Emissions Monitoring and Verification Support Capacity
Under the Paris Agreement (PA), progress of emission reduction efforts is tracked on the basis of regular updates to national greenhouse gas (GHG) inventories, referred to as bottom-up estimates. However, only top-down atmospheric measurements can provide observation-based evidence of emission trends. Today, there is no internationally agreed, operational capacity to monitor anthropogenic GHG emission trends using atmospheric measurements to complement national bottom-up inventories. The European Commission (EC), the European Space Agency, the European Centre for Medium-Range Weather Forecasts, the European Organisation for the Exploitation of Meteorological Satellites, and international experts are joining forces to develop such an operational capacity for monitoring anthropogenic CO₂ emissions as a new CO₂ service under the EC’s Copernicus program. Design studies have been used to translate identified needs into defined requirements and functionalities of this anthropogenic CO₂ emissions Monitoring and Verification Support (CO₂MVS) capacity. It adopts a holistic view and includes components such as atmospheric spaceborne and in situ measurements, bottom-up CO₂ emission maps, improved modeling of the carbon cycle, an operational data-assimilation system integrating top-down and bottom-up information, and a policy-relevant decision support tool. The CO₂MVS capacity with operational capabilities by 2026 is expected to visualize regular updates of global CO₂ emissions, likely at 0.05° × 0.05°. This will complement the PA’s enhanced transparency framework, providing actionable information on anthropogenic CO₂ emissions that are the main driver of climate change. This information will be available to all stakeholders, including governments and citizens, allowing them to reflect on trends and effectiveness of reduction measures. The new EC gave the green light to pass the CO₂MVS from exploratory to implementing phase.
Journal Article
Phase transition kinetics of superionic H2O ice phases revealed by Megahertz X-ray free-electron laser-heating experiments
H
2
O transforms to two forms of superionic (SI) ice at high pressures and temperatures, which contain highly mobile protons within a solid oxygen sublattice. Yet the stability field of both phases remains debated. Here, we present the results of an ultrafast X-ray heating study utilizing MHz pulse trains produced by the European X-ray Free Electron Laser to create high temperature states of H
2
O, which were probed using X-ray diffraction during dynamic cooling. We confirm an isostructural transition during heating in the 26-69 GPa range, consistent with the formation of SI-bcc. In contrast to prior work, SI-fcc was observed exclusively above ~50 GPa, despite evidence of melting at lower pressures. The absence of SI-fcc in lower pressure runs is attributed to short heating timescales and the pressure-temperature path induced by the pump-probe heating scheme in which H
2
O was heated above its melting temperature before the observation of quenched crystalline states, based on the earlier theoretical prediction that SI-bcc nucleates more readily from the fluid than SI-fcc. Our results may have implications for the stability of SI phases in ice-rich planets, for example during dynamic freezing, where the preferential crystallization of SI-bcc may result in distinct physical properties across mantle ice layers.
The authors perform heating experiments using femtosecond X-ray free electron laser pulses to explore the phase stability of superionic H
2
O. The absence of a face-centered cubic phase below 50 GPa, where superionic ice forms from the melt, is attributed to the short heating time and may help understanding the stability of superionic phases in ice-rich planets.
Journal Article
Observation of a mixed close-packed structure in superionic water
The study of superionic (SI) water has been a highly active research area since its theoretical prediction. Despite significant experimental and computational efforts, its melting curve and the stability of different oxygen lattices remain debated, impacting our understanding of SI ice’s peculiar transport properties. Experimental results at lower pressures show disagreement, whereas data at higher pressures are scarce due to the extreme challenges of such experiments. In this work, we present ultrafast X-ray diffraction results of water compressed by multiple shocks to pressures up to ~ 180 GPa. At pressures exceeding 150 GPa and temperatures around 2500 K, our diffraction patterns challenge the pure FCC-SI phase model, providing experimental evidence of the mixed close-packed superionic phase predicted by advanced ab initio calculations. At lower pressures, we observe simultaneous signatures of BCC and FCC structures within a pressure-temperature range consistent with some static-compression experiments, helping to resolve contradictory results in literature. These insights offer new constraints on the stability domains of SI phases and reveal detailed structural features, such as stacking faults. Our results advance the structural understanding of high-pressure SI ice to a level approaching that of ice I polymorphs, with potential implications for water-rich interiors of giant planets.
X-ray study of compressed water shows that superionic ice adopts mixed close-packed structures rather than a single phase - a far more complex behaviour than expected, mirroring solid ice’s rich phases and informing planetary interior models.
Journal Article
Model‐based evaluation of image‐guided fractionated whole‐brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts
Radiation therapy (RT) is currently the standard treatment for diffuse intrinsic pontine glioma (DIPG), the most common cause of death in children with brain cancer. A pharmacodynamic model was developed to describe the radiation‐induced tumor shrinkage and overall survival in mice bearing DIPG. CD1‐nude mice were implanted in the brain cortex with luciferase‐labeled patient‐derived orthotopic xenografts of DIPG (SJDIPGx7 H3F3AWT/K27 M and SJDIPGx37 H3F3AK27M/K27M). Mice were treated with image‐guided whole‐brain RT at 1 or 2 Gy/fraction 5‐days‐on 2‐days‐off for a cumulative dose of 20 or 54 Gy. Tumor progression was monitored with bioluminescent imaging (BLI). A mathematical model describing BLI and overall survival was developed with data from mice receiving 2 Gy/fraction and validated using data from mice receiving 1 Gy/fraction. BLI data were adequately fitted with a logistic tumor growth function and a signal distribution model with linear radiation‐induced killing effect. A higher tumor growth rate in SJDIPGx37 versus SJDIPGx7 xenografts and a killing effect decreasing with higher tumor baseline (p < 0.0001) were identified. Cumulative radiation dose was suggested to inhibit the tumor growth rate according to a Hill function. Survival distribution was best described with a Weibull hazard function in which the hazard baseline was a continuous function of tumor BLI. Significant differences were further identified between DIPG cell lines and untreated versus treated mice. The model was adequately validated with mice receiving 1 Gy/fraction and will be useful in guiding future preclinical trials incorporating radiation and to support systemic combination therapies with RT.
Journal Article
Molecular diversity of arbuscular mycorrhizal fungi colonising arable crops
We used differences in small subunit ribosomal RNA genes to identify groups of arbuscular mycorrhizal fungi that are active in the colonisation of plant roots growing in arable fields around North Yorkshire, UK. Root samples were collected from four arable fields and four crop species, fungal sequences were amplified from individual plants by the polymerase chain reaction using primers NS31 and AM1. The products were cloned and 303 clones were classified by their restriction pattern with
HinfI or
RsaI; 72 were subsequently sequenced. Colonisation was dominated by
Glomus species with a preponderance of only two sequence types, which are closely related. There is evidence for seasonal variation in colonisation in terms of both level of colonisation and sequence types present. Fungal diversity was much lower than that previously reported for a nearby woodland.
Journal Article
Ploughing up the wood-wide web?
Key species groups that affect major ecological processes are vital components of community diversity. Many such key groups are found in the soil, including the mycorrhizal fungi that may connect plants into a functional “wood-wide web”
1
. Arbuscular mycorrhizal associations are formed by fungi of the order Glomales with 90% of land plant families, and many arbuscular mycorrhizal fungi are thought to have a broad host range
2
. Here we show that, despite this broad host range, the diversity of arbuscular mycorrhizal fungi is strikingly low in arable sites compared with a woodland.
Journal Article
Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique
Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery.
Patients were prospectively recruited between May 2017 and June 2018. Inclusion criteria stipulated biopsy-proven metastatic cervical squamous cell carcinoma, with negative findings on magnetic resonance imaging and positron emission tomography/computed tomography, in addition to examination under anaesthetic, tonsillectomy and 'blind' tongue base biopsies without tumour identification, prior to mucosectomy.
Of nine patients, a mucosal primary was identified in four (44.4 per cent), for which ipsilateral intensity-modulated radiotherapy was advocated in three and completion tongue base resection in the fourth. Dysplasia was demonstrated in two further patients, which provided information relevant to radiotherapy fields and post-treatment surveillance. No surgical complications were identified.
Tongue base mucosectomy using electrocautery and conventional tonsillectomy equipment is a safe, effective technique in the identification of cervical metastasis from an unknown primary site. It expands the potential breadth of use, quickens prolonged diagnostic pathways and obviates the necessity for pan-mucosal irradiation.
Journal Article