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•We here report two new cases of insulin autoimmune syndrome (IAS) triggered by alpha lipoic acid in two Caucasian women.•This new cases are associated with HLA-DRB1*04:03, confirming the evidence that HLADRB1*04:03, rather than HLA-DRB1*04:06, is specifically related to IAS susceptibility in Europeans.•Case reports of ALA-induced hypoglycemic episodes impose the need of greater attention in prescribing alpha lipoic acid supplementation, identifying specific and personalized therapeutic targets. Insulin autoimmune syndrome (IAS) or Hirata disease is a rare cause of autoimmune hypoglycemia with apparent high insulin levels and anti-insulin autoantibodies and was first described by Hirata in Japan in 1970. IAS cases are usually related to exposure to sulfhydryl-containing drugs, which stimulate the production of insulin autoantibodies. Among sulfhydryl-containing compounds, alpha lipoic acid (ALA) has recently emerged as a cause of IAS. After the first observations of ALA-induced IAS were reported in Japan in 2006, an increasing number of cases related to ALA administration have been described. An Italian group recently reported on six cases of IAS of which one was associated with HLA-DRB1*04:06 and the remaining five with HLA-DRB1*04:03. This suggests that the latter is potentially involved in the genetic susceptibility of people of European descent to IAS. Here, we describe two new cases of IAS in women that were triggered by ALA. Both cases are associated with HLA-DRB1*04:03 and confirm the evidence that HLA-DRB1*04:03 rather than HLA-DRB1*04:06 is specifically related to IAS susceptibility in Europeans. Case reports of ALA-induced hypoglycemic episodes highlight the need for greater care in prescribing ALA supplementation as well as the identification of specific and personalized therapeutic targets.

This study investigates the combined use of electron beam irradiation (EBI) and nanotechnology to develop improved food packaging films. EBI, commonly applied for sterilization, can alter polymer microstructure, while irradiated cellulose nanocrystals (CNCs) offer enhanced functionality when incorporated into biopolymer matrices. Here, CNCs were irradiated with doses up to 50 kGy, leading to the formation of carboxyl and aldehyde groups, confirmed by FTIR analysis, as a consequence of the initial formation of free radicals and peroxides that may subsist in that original form or be converted into various carbonyl groups. Flexible films were obtained by incorporating pristine and EB-irradiated CNCs in an internal mixer, using minute amounts of poly(ethylene oxide) (PEO) to facilitate the dispersion of the filler within the polymer matrix. The resulting PLA/PEO/CNC films were evaluated for their mechanical, thermal, barrier, and antioxidant properties. The results showed that structural modifications of CNCs led to significant enhancements in the performance of the composite films, including a 30% improvement in water barrier properties and a 50% increase in antioxidant activity. These findings underscore the potential of irradiated CNCs as effective additives in biopolymer-based active packaging, offering a sustainable approach to reduce dependence on synthetic preservatives and potentially extend the shelf life of food products.

Developmental data suggested that mental simulation skills become progressively dissociated from overt motor activity across development. Thus, efficient simulation is rather independent from current sensorimotor information. Here, we tested the impact of bodily (sensorimotor) information on simulation skills of adolescents with Autism Spectrum Disorders (ASD). Typically-developing (TD) and ASD participants judged laterality of hand images while keeping one arm flexed on chest or while holding both arms extended. Both groups were able to mentally simulate actions, but this ability was constrained by body posture more in ASD than in TD adolescents. The strong impact of actual body information on motor simulation implies that simulative skills are not fully effective in ASD individuals.

Carbon Fibre Reinforced Polymer (CFRP) composites are widely used in aerospace applications that require severe quality parameters. To simplify the assembly operations and reduce the associated costs, the current trend in industry is to optimize the drilling processes. However, the machining of CFRP composites is very challenging compared with metals, and several defect types can be generated by drilling. The emerging process of orbital drilling can greatly reduce the defects associated with the traditional drilling of CFRP, but it is a more complex process requiring careful process parameters selection and it does not allow for the complete elimination of the thrust force responsible for delamination damage. As an alternative to traditional and orbital drilling, this work presents a new hole making process, where the hole is realized by a combination of drilling and peripheral milling performed using the same cutting tool following a novel tool path strategy. An original tool design principle is proposed to realize a new drill-milling tool, made of a first drilling and a subsequent milling portion. Two different tool configurations are experimentally tested to evaluate the performance of the newly-conceived combined drill-milling process. This process is quick and easy, and the experimental results show an improvement in the drilled hole quality.

Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS.

Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are fundamental non-pharmacological components of T2DM therapy. Exercise interventions are strongly recommended for people with or at risk of developing or already with overt diabetes, but adherence to PA guidelines in this population is still challenging. Furthermore, the heterogeneity of T2DM patients, driven by differing residual β-cell functionality, as well as the possibility of practicing different types and intensities of PA, has led to the need to develop tailored exercise and training plans. Investigations on blood glucose variation in response to exercise could help to clarify why individuals do not respond in the same way to PA, and to guide the prescription of personalized treatments. The aim of this review is to offer an updated overview of the current evidence on the effects of different regimens and modalities of PA regarding glucose sensing and β-cell secretory dynamics in individuals with prediabetes or T2DM, with a special focus on β-cell function.

This research explores the development of highly durable flexible electronic textiles (e-textiles) for wearable electronics, focusing on improving their washability and performance. A conductive graphene-based ink was screen-printed onto a polyester textile. Water-based polyurethane (PU) coatings with variable crosslinker ratios and thickener were applied to solve washability issues. The results show that the PU coatings significantly enhanced the electrical stability and durability of the printed pathways after multiple washing cycles. The conductivity remained intact after 120 washing cycles, indicating that the final properties of the e-textile, which contained 6 wt% thickener and 3 wt% crosslinker, provided effective water protection. The results highlight the promise of these coated e-textiles for wearable electronics applications, especially in the occupational and healthcare sectors, where long-term flexibility and washability are critical.

This contribution shows part of a research activity aimed at supporting data documentation related to artworks and decorative apparatuses that characterize the architectural heritage using bSDD as a methodological tool. The proposal approach aims to provide specific information in SCAN-to-BIM processes, implementing HBIM models of decorative apparatuses or artworks with data on the state of conservation and morphological-structural composition according to the material of each component of the system (Lanzara and Scandurra, 2023). The main goal of this activity is the creation of open and detailed information models shareable and consultable via IFC exchange format (ISO 16739:2018), supporting conservation, prevention, maintenance and restoration of historical-artistic heritage. The use of codes, manuals, vocabularies and thesauri, and the multidisciplinary knowledge of specialists, shared within the theoretical and operational framework of the restoration and conservation of cultural heritage, informally contribute to supplement existing codes and to implement/define new datasets for information about deficient and not codified conservation states for specific materials. The structuring of the Data Dictionary is supported by ACCA software's usBIM.bSDD application, accessible via a collaborative web-based platform (Scandurra and di Luggo, 2023). According to the proposed workflow, shared terms and definitions can be integrated within the graphic model of the manufacts and structured within a CDE – Common Data Environment. The system, which has already been tested in the context of historical architecture, is currently being tested on movable and immovable decorative apparatuses and artworks, selected for their constituent materials and compositional complexity. This contribution presents the experimentation on the decorative apparatus of the major altar of the Church of Santa Maria di Costantinopoli in Naples.

To explore the neuropsychological and neurobehavioral profile in adult patients affected by nonsymptomatic (cryptogenic and idiopathic) occipital lobe epilepsy (OLE), with normal intelligence, we enrolled 20 adult patients with nonsymptomatic OLE and 20 age-, sex-, and education-matched healthy subjects. All participants underwent neuropsychiatric assessment scales, and standardized neuropsychological tests tapping memory, executive functions, constructional, visuospatial and visuoperceptual skills. After Bonferroni correction for multiple comparisons, patients performed significantly worse than controls on several tests tapping complex visuospatial skills and frontal lobe functions. The analysis of single patients’ performance revealed that a significantly higher number of OLE patients achieved age- and education-adjusted pathological scores on three tests (Benton Judgment of Line Orientation Test, Freehand Copying of Drawings Test, color-word interference task of Stroop test) with respect to controls. Patients did not differ from control subjects on neuropsychiatric aspects. The direct comparison between OLE subtypes showed that cryptogenetic OLE patients tended to achieve lower scores than idiopathic OLE patients on most tests, but no difference between the two groups was fully significant. In summary, patients with nonsymptomatic OLE can be affected by clinically relevant impairments in selected neuropsychological domains: complex visuospatial skills and executive functions. It could be speculated that frontal and visuospatial cognitive deficits might be the result of epileptic activity spreading within a neural network that includes structures far beyond the occipital lobe.

Aim To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer. Patients and methods In a multi-centric prospective study, the International Index of Erectile Function (IIEF) questionnaire-based potency of 91 hormone-naïve and potent patients (IIEF1-5 > 11 before radiotherapy) was assessed. At the time of this analysis, information on potency 1 year after treatment was available for 62 of 91 patients (42 treated with hypofractionation: 2.35–2.65 Gy/fr, 70–74.2 Gy; 20 with conventional fractionation: 74–78 Gy). Prospectively collected individual information and D max /D mean to the penile bulb were available; the corresponding 2 Gy-equivalent values (EQD2 _max /EQD2 _mean ) were also considered. Predictors of 1‑year impotency were assessed through uni- and multi-variable backward logistic regression: The best cut-off values discriminating between potent and impotent patients were assessed by ROC analyses. The discriminative power of the models and goodness-of-fit were measured by AUC analysis and the Hosmer–Lemeshow (H&L) test. Results At 1‑year follow-up, 26 of 62 patients (42 %) became impotent. The only predictive variables were baseline IIEF1-5 values (best cut-off baseline IIEF1-5 ≥ 19), D max ≥ 68.5 Gy and EQD2 _max ≥ 74.2 Gy. The risk of 1‑year impotence may be predicted by a two-variable model including baseline IIEF1-5 (OR: 0.80, p  = 0.003) and EQD2 _max ≥ 74.2 Gy (OR: 4.1, p  = 0.022). The AUC of the model was 0.77 (95% CI: 0.64–0.87, p  = 0.0007, H&L: p  = 0.62). The 1‑year risk of impotency after high-dose radiotherapy in potent men depends on the EQD2 _max to the penile bulb and on baseline IIEF1-5 values. Conclusion A significant reduction in the risk may be expected mainly when sparing the bulb in patients with no/mild baseline impotency (IIEF1-5 > 17).