Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
29,586
result(s) for
"J -H Yu"
Sort by:
Identification of Five Driver Gene Mutations in Patients with Treatment-Naïve Lung Adenocarcinoma in Taiwan
It is important to select appropriate targeted therapies for subgroups of patients with lung adenocarcinoma who have specific gene alterations.
This prospective study was a multicenter project conducted in Taiwan for assessment of lung adenocarcinoma genetic tests. Five oncogenic drivers, including EGFR, KRAS, BRAF, HER2 and EML4-ALK fusion mutations, were tested. EGFR, KRAS, BRAF and HER2 mutations were assessed by MALDI-TOF MS (Cohort 1). EML4-ALK translocation was tested by Ventana method in EGFR-wild type patients (Cohort 2).
From August 2011 to November 2013, a total of 1772 patients with lung adenocarcinoma were enrolled. In Cohort 1 analysis, EGFR, KRAS, HER2 and BRAF mutations were identified in 987 (55.7%), 93 (5.2%), 36 (2.0%) and 12 (0.7%) patients, respectively. Most of these mutations were mutually exclusive, except for co-mutations in seven patients (3 with EGFR + KRAS, 3 with EGFR + HER2 and 1 with KRAS + BRAF). In Cohort 2 analysis, 29 of 295 EGFR-wild type patients (9.8%) were positive for EML4-ALK translocation. EGFR mutations were more common in female patients and non-smokers and KRAS mutations were more common in male patients and smokers. Gender and smoking status were not correlated significantly with HER2, BRAF and EML4-ALK mutations. EML4-ALK translocation was more common in patients with younger age.
This was the first study in Taiwan to explore the incidence of five oncogenic drivers in patients with lung adenocarcinoma and the results could be valuable for physicians in consideration of targeted therapy and inclusion of clinical trials.
Journal Article
Direct observations of anomalous resistivity and diffusion in collisionless plasma
Coulomb collisions provide plasma resistivity and diffusion but in many low-density astrophysical plasmas such collisions between particles are extremely rare. Scattering of particles by electromagnetic waves can lower the plasma conductivity. Such anomalous resistivity due to wave-particle interactions could be crucial to many processes, including magnetic reconnection. It has been suggested that waves provide both diffusion and resistivity, which can support the reconnection electric field, but this requires direct observation to confirm. Here, we directly quantify anomalous resistivity, viscosity, and cross-field electron diffusion associated with lower hybrid waves using measurements from the four Magnetospheric Multiscale (MMS) spacecraft. We show that anomalous resistivity is approximately balanced by anomalous viscosity, and thus the waves do not contribute to the reconnection electric field. However, the waves do produce an anomalous electron drift and diffusion across the current layer associated with magnetic reconnection. This leads to relaxation of density gradients at timescales of order the ion cyclotron period, and hence modifies the reconnection process.
It is suggested that waves can provide both diffusion and resistivity that can potentially support the reconnection electric field in low-density astrophysical plasmas. Here, the authors show, using direct spacecraft measurements, that the waves contribute to anomalous diffusion but do not contribute to the reconnection electric field.
Journal Article
Effect of Salt Substitution on Cardiovascular Events and Death
In a cluster-randomized trial, villages were assigned in a 1:1 ratio to use a salt substitute (75% sodium chloride and 25% potassium chloride by mass) or regular salt. Among persons who had a history of stroke or were 60 years of age or older and had hypertension, rates of stroke, major cardiovascular events, and death were lower with the salt substitute, which had no apparent serious adverse effects.
Journal Article
علم السموم والكيمياء الحيوية للمبيدات الحشرية
يتناول هذا الكتاب مباشرة سمية المبيدات الحشرية ضد الحشرات بصورة مركزة من ناحية مجاميع المبيدات الحشرية وطرق تأثيرها واختيارية العديد من هذه المبيدات ضد الآفات المستهدفة وعدم سميتها لبعض الأعداء الحيوية المهمة وأسباب هذه الاختيارية وكيفية استغلال ذلك في برامج المكافحة المتكاملة للحفاظ على الأعداء الحيوية. ويوضح الكتاب أيضا الأسس الكيموحيوية لتأثير العديد من المبيدات على الآفات وعدم سميتها للثدييات. وتناول الكتاب أيضا العديد من المبيدات التي لها تأثيرات ضارة على الأعداء الحيوية لتجنب استخدامها في البيئات التي توجد فيها هذه الكائنات النافعة. كما يذكر الكتاب بعض النباتات المقاومة للحشرات والمواد التي تفرزها للدفاع عن نفسها ضد هذه الحشرات. ويضم الكتاب فكرة عن القوانين المنظمة للمبيدات وصور تجهيزاتها ومقاومة الآفات لها وأيضا مصير المبيدات في البيئة وتمثيلها في الحشرات وطرق تقسيم المبيدات الحشرية، والمجاميع الحديثة للمبيدات الحشرية والأكاروسية واستعمالاتها.
BOOK
Emergence and Persistent Dominance of SARS-CoV-2 Omicron BA.2.3.7 Variant, Taiwan
Since April 2022, waves of SARS-CoV-2 Omicron variant cases have surfaced in Taiwan and spread throughout the island. Using high-throughput sequencing of the SARS-CoV-2 genome, we analyzed 2,405 PCR-positive swab samples from 2,339 persons and identified the Omicron BA.2.3.7 variant as a major lineage within recent community outbreaks in Taiwan.
Journal Article
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs
G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals. Although several structures have been solved for GPCR–G protein complexes, few are in a lipid membrane environment. Here, we report cryo-EM structures of complexes of neurotensin, neurotensin receptor 1 and Gα
i1
β
1
γ
1
in two conformational states, resolved to resolutions of 4.1 and 4.2 Å. The structures, determined in a lipid bilayer without any stabilizing antibodies or nanobodies, reveal an extended network of protein–protein interactions at the GPCR–G protein interface as compared to structures obtained in detergent micelles. The findings show that the lipid membrane modulates the structure and dynamics of complex formation and provide a molecular explanation for the stronger interaction between GPCRs and G proteins in lipid bilayers. We propose an allosteric mechanism for GDP release, providing new insights into the activation of G proteins for downstream signaling.
Structures of GPCR neurotensin receptor 1 (NTSR1) in complex with neurotensin and Gα
i1
β
1
γ
1
in a lipid bilayer environment and without stabilizing antibodies reveal extensive interactions at the GPCR–G protein interface.
Journal Article