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Effect of Salt Substitution on Cardiovascular Events and Death

by Hao, Zhixin , Feng, Xiangxian , Zhang, Ruijuan , Yin, Xuejun , Wang, Faxuan , Zhao, Yi , Yan, Lijing L , Zhang, Yuhong , Zhang, Jianxin , Li, Zhifang , Stepien, Sandrine , Yu, Jie , Duan, Peifen , Huang, Liping , Di Tanna, Gian Luca , Tian, Maoyi , Li, Ka-Chun , Zhang, Xinyi , Elliott, Paul , Ma, Bing , Neal, Bruce , Liu, Yishu , Wu, Yangfeng , Shan, Sana , Shi, Jingpu , Labarthe, Darwin , Zhou, Bo , Shi, Weiwei , Sun, Jixin , Pearson, Sallie-Anne , Yu, Yan , Li, Nicole

in Acute coronary syndromes / Adverse events / Aged / Blood pressure / Cardiology / Cardiovascular Diseases - epidemiology / Cardiovascular Diseases - prevention & control / China / Chloride / COVID-19 / Death / Diet / Diet, Sodium-Restricted - adverse effects / Female / Food preservation / Gastroenterology / Humans / Hyperkalemia / Hyperkalemia - complications / Hypertension / Hypertension - complications / Hypertension - diet therapy / Hypertension - epidemiology / Kidney diseases / Male / Medical research / Middle Aged / Mortality / Neurology / Neurosurgery / Nutrition / Potassium / Potassium chloride / Potassium, Dietary - adverse effects / Rural areas / Salt / Secondary Prevention / Sodium / Sodium chloride / Statistical analysis / Stroke / Stroke - epidemiology / Stroke - prevention & control

2021

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2021

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2021

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Journal Article

Effect of Salt Substitution on Cardiovascular Events and Death

Hao, Zhixin,

Feng, Xiangxian,

Zhang, Ruijuan,

Yin, Xuejun,

Wang, Faxuan,

Zhao, Yi,

Yan, Lijing L,

Zhang, Yuhong,

Zhang, Jianxin,

Li, Zhifang,

Stepien, Sandrine,

Yu, Jie,

Duan, Peifen,

Huang, Liping,

Di Tanna, Gian Luca,

Tian, Maoyi,

Li, Ka-Chun,

Zhang, Xinyi,

Elliott, Paul,

Ma, Bing,

Neal, Bruce,

Liu, Yishu,

Wu, Yangfeng,

Shan, Sana,

Shi, Jingpu,

Labarthe, Darwin,

Zhou, Bo,

Shi, Weiwei,

Sun, Jixin,

Pearson, Sallie-Anne,

Yu, Yan,

Li, Nicole

2021

Overview

In a cluster-randomized trial, villages were assigned in a 1:1 ratio to use a salt substitute (75% sodium chloride and 25% potassium chloride by mass) or regular salt. Among persons who had a history of stroke or were 60 years of age or older and had hypertension, rates of stroke, major cardiovascular events, and death were lower with the salt substitute, which had no apparent serious adverse effects.

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Publisher

Massachusetts Medical Society

Subject

Acute coronary syndromes

/ Adverse events

/ Aged

/ Blood pressure

/ Cardiology

/ Cardiovascular Diseases - epidemiology

/ Cardiovascular Diseases - prevention & control