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"Jalaluddin"
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Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress
The micro- and macro-complications in diabetes mellitus (DM) mainly arise from the damage induced by Amadori and advanced glycation end products, as well as the released free radicals. The primary goal of DM treatment is to reduce the risk of micro- and macro-complications. In this study, we looked at the efficacy of aminoguanidine (AG) to prevent the production of early glycation products in alloxan-diabetic rabbits. Type1 DM was induced in rabbits by a single intravenous injection of alloxan (90 mg/kg body weight). Another group of rabbits was pre-treated with AG (100 mg/kg body weight) prior to alloxan injection; this was followed by weekly treatment with 100 mg/kg of AG for eight weeks. Glucose, insulin, and early glycation products (HbA1 C and fructosamine) were measured in control, diabetic and AG treated diabetic rabbits. The effects of hyperglycemia on superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), reduced glutathione (rGSH), nitric oxide, lipid peroxides, and protein carbonyl were investigated. Alloxan-diabetic rabbits had lower levels of SOD, CAT, Gpx, and rGSH than control rabbits. Nitric oxide levels were considerably greater. AG administration restored the activities of SOD, CAT, Gpx enzymes up to 70–80% and ameliorated the nitric oxide production. HbA1c and fructosamine levels were considerably lower in AG-treated diabetic rabbits. The observed control of hyperglycemia and amadori adducts in alloxan-diabetic rabbits by AG may be attributed to decrease of stress and restoration of antioxidant defenses.
Journal Article
Hana Khan carries on
\"A young woman juggles pursuing her dream job in radio while helping her family compete with the new halal restaurant across the street, in this sparkling new rom-com by the author of Ayesha at Last. Sales are slow at Three Sisters Biryani Poutine, the only halal restaurant in the close-knit Golden Crescent neighborhood of Toronto. Hana waitresses there part time, but what she really wants is to tell stories on the radio. If she can just outshine her fellow intern at the city radio station, she may have a chance at landing a job. In the meantime, Hana pours her thoughts and dreams into a podcast, where she forms a lively relationship with one of her listeners. But soon she'll need all the support she can get: a new competing restaurant, a more upscale halal place, is about to open in the Golden Crescent, threatening her mother's restaurant. When her mysterious aunt and her teenage cousin arrive from India for a surprise visit, they draw Hana into a long-buried family secret. A hate-motivated attack on their neighborhood complicates the situation further, as does Hana's growing attraction for Aydin, the young owner of the rival restaurant-who might not be a complete stranger after all. As life on the Golden Crescent unravels, Hana must learn to use her voice, draw on the strength of her community and decide what her future should be\"-- Provided by publisher.
BOOK
Social Inclusion Indicators for Building Citizen-Centric Smart Cities: A Systematic Literature Review
Despite the rhetoric of “citizen-first,” which has been tokenized in recent years by the smart city administrations, what it means has long been unclear to many, including the public at large. Put simply, this rhetoric concerns the mindset of the members of a local community and places them at the heart of the smart city initiatives. In order to bring further clarity to this issue under the current neoliberal urbanism, this study aimed to identify the key indicators of citizen-centric smart cities from the perspective of participative governance practices and citizens’ responsibilities. To achieve this aim, this study involved a systematic literature review of the social inclusion indicators for building citizen-centric smart cities. The social inclusion indicators that were formed were verified by practitioners to suit the local contexts of an emerging and developing country, in this case, Malaysia. The findings of the review revealed that: (a) the acceptance of social inclusion indicators was mainly limited to the realm of democratic developed countries, leaders’ understanding of citizenship, the delegation of decision-making power in governance practices, the participative culture of societies, and individual citizens’ self-discipline; (b) the social inclusion indicators may not be welcomed in emerging and developing countries; (c) in the long term, these indicators would shed light on the rise of self-organizing cities that will gain popularity in potential city developments, be it in developed or developing countries.
Journal Article
Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques
Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors implicated in secondary complications of diabetes. Scientists are focusing on discovering new compounds that may be used as potential AGEs inhibitors without affecting the normal structure and function of biomolecules. A number of natural and synthetic compounds have been proposed as AGE inhibitors. In this study, we investigated the inhibitory effects of AgNPs (silver nanoparticles) in AGEs formation. AgNPs (~30.5 nm) synthesized from Aloe Vera leaf extract were characterized using UV-Vis spectroscopy, energy-dispersive X-ray spectroscopy (EDX), high resolution-transmission electron microscopy, X-ray diffraction and dynamic light scattering (DLS) techniques. The inhibitory effects of AgNPs on AGEs formation were evaluated by investigating the degree of reactivity of free amino groups (lysine and arginine residues), protein-bound carbonyl and carboxymethyl lysine (CML) content and the effects on protein structure using various physicochemical techniques. The results showed that AgNPs significantly inhibit AGEs formation in a concentration dependent manner and that AgNPs have a positive effect on protein structure. These findings strongly suggest that AgNPs may play a therapeutic role in diabetes-related complications.
Journal Article
Recent Progress on Nanocarriers for Topical-Mediated RNAi Strategies for Crop Protection—A Review
To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops from these pests and other pathogens such as viruses and fungi. An alternative pathogen control mechanism that is more “friendly” to the environment can be developed by externally applying double-stranded RNAs (dsRNAs) to suppress gene expression. However, the use of dsRNA sprays in open fields is complicated with respect to variable efficiencies in the dsRNA delivery, and the stability of the dsRNA on and in the plants, and because the mechanisms of gene silencing may differ between plants and between different pathogen targets. Thus, nanocarrier delivery systems have been especially used with the goal of improving the efficacy of dsRNAs. Here, we highlight recent developments in nanoparticle-mediated nanocarriers to deliver dsRNA, including layered double hydroxide, carbon dots, carbon nanotubes, gold nanoparticles, chitosan nanoparticles, silica nanoparticles, liposomes, and cell-penetrating peptides, by review of the literature and patent landscape. The effects of nanoparticle size and surface modification on the dsRNA uptake efficiency in plants are also discussed. Finally, we emphasize the overall limitation of dsRNA sprays, the risks associated, and the potential safety concerns for spraying dsRNAs on crops.
Journal Article
Ethical and legal implications of gene editing in plant breeding: a systematic literature review
Biotechnology policies and regulations must be revised and updated to reflect the most recent advances in plant-breeding technology. New Plant Breeding Techniques (NPBT) such as gene editing have been applied to address the myriad of challenges in plant breeding, while the use of NPBT as emerging biotechnological tools raises legal and ethical concerns. This study aims to highlight how gene editing is operationalized in the existing literature and examine the critical issues of ethical and legal issues of gene editing for plant breeding. We carried out a systematic literature review (SLR) to provide the current states of ethical and legal discourses surrounding this topic. We also identified critical research priority areas and policy gaps that must be addressed when designing the future governance of gene editing in plant breeding.
Journal Article
3-Deoxyglucosone: A Potential Glycating Agent Accountable for Structural Alteration in H3 Histone Protein through Generation of Different AGEs
Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One of the consequences of the Maillard reaction is attributed to the production of reactive intermediate products such as α-oxoaldehydes. 3-deoxyglucosone (3-DG), an α-oxoaldehyde has been found to be involved in accelerating vascular damage during diabetes. In the present study, calf thymus histone H3 was treated with 3-deoxyglucosone to investigate the generation of AGEs (Nε-carboxymethyllysine, pentosidine), by examining the degree of side chain modifications and formation of different intermediates and employing various physicochemical techniques. The results clearly indicate the formation of AGEs and structural changes upon glycation of H3 by 3-deoxyglucosone, which may hamper the normal functioning of H3 histone, that may compromise the veracity of chromatin structures and function in secondary complications of diabetes.
Journal Article
Innovative Governance of Blue Economy in Coastal Community Empowerment Bintan Regency
This study explores the application of blue economy principles to empower coastal communities in Bintan Regency, which possesses abundant marine resources. Through qualitative methods, including in-depth interviews, field observations, and document reviews, the research identifies key challenges such as external interference, financial constraints, and a lack of skilled human resources. Despite these barriers, initiatives like job skills training, financial aid, and eco-tourism development are underway. The findings highlight the importance of community involvement in governance, emphasizing that local populations must actively participate in decision- making processes. Additionally, the study recommends robust monitoring and evaluation systems to support adaptive policies, with collaboration between government, the private sector, and local communities being essential. Ultimately, the research provides policy recommendations to foster an inclusive and sustainable blue economy that addresses socio- economic disparities and positions communities as active agents of change in their own empowerment.
Journal Article
Scale-up fermentation of Escherichia coli for the production of recombinant endoglucanase from Clostridium thermocellum
Endoglucanase (EC 3.2.1.4) catalysing the hydrolysis of β-1.4-glycosidic linkage of cellulose molecules is an enzyme of tremendous industrial importance. The present study describes a response surface methodology based predicted model to deduce a set of fermentation conditions for optimum growth and activity of recombinant endoglucanase in
E. coli
BL21 (DE3). Numerous significant parameters including fermentation media composition, temperature (Celsius), pH and agitation rate (rpm) were analysed systemically by employing central composite design. This effort reports highly efficient recombinant endoglucanase overproduction (6.9 gl
−1
of biomass) with 30% expression by
E. coli
in modified M9NG media incubated at 37 °C and pH 7 agitated at 200 rpm. Addition of 3 mM glucose and 24 mM glycerol in the M9NG media has shown positive effect on the enzyme yield and activity. The CMCase activity experimentally estimated was found to be 1185 U/mg with the optimized parameters. The outcomes of both the responses by the predicted quadratic model were found in consensus with the obtained values. Our results well depicted the favourable conditions to further scale-up the volumetric yield of other relevant recombinant enzymes and proteins.
Journal Article