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Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques
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Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques
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Journal Article
Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques
2016
Overview
Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors implicated in secondary complications of diabetes. Scientists are focusing on discovering new compounds that may be used as potential AGEs inhibitors without affecting the normal structure and function of biomolecules. A number of natural and synthetic compounds have been proposed as AGE inhibitors. In this study, we investigated the inhibitory effects of AgNPs (silver nanoparticles) in AGEs formation. AgNPs (~30.5 nm) synthesized from Aloe Vera leaf extract were characterized using UV-Vis spectroscopy, energy-dispersive X-ray spectroscopy (EDX), high resolution-transmission electron microscopy, X-ray diffraction and dynamic light scattering (DLS) techniques. The inhibitory effects of AgNPs on AGEs formation were evaluated by investigating the degree of reactivity of free amino groups (lysine and arginine residues), protein-bound carbonyl and carboxymethyl lysine (CML) content and the effects on protein structure using various physicochemical techniques. The results showed that AgNPs significantly inhibit AGEs formation in a concentration dependent manner and that AgNPs have a positive effect on protein structure. These findings strongly suggest that AgNPs may play a therapeutic role in diabetes-related complications.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/699
/ 96/35
/ Advanced glycosylation end products
/ Arginine
/ Chromatography, High Pressure Liquid
/ Diabetes
/ Glycation End Products, Advanced - antagonists & inhibitors
/ Humanities and Social Sciences
/ Lysine
/ Metal Nanoparticles - chemistry
/ Proteins
/ Science
/ Silver
/ Silver - administration & dosage
/ Structure-function relationships
/ Studies
