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Explaining the significant variability of rainfall in orographically complex mountainous regions remains a challenging task even for modern raingauge networks. To address this issue, a real-time spatial rainfall field estimation model, called WREPN (WRF Rainfall-Elevation Parameterized Nowcasting), has been developed, incorporating the influence of mountain effect based on ground raingauge networks. In this study, we examined the effect of mountainous rainfall estimates on the uncertainty of flood model parameter estimation. As a comparison, an inverse distance weighting technique was applied to ground raingauge data to estimate the spatial rainfall field. To convert the spatial rainfall fields into flood volumes, we employed the ModClark model, a conceptual rainfall–runoff model with distributed rainfall input. Bayesian theory was applied for parameter estimation to incorporate uncertainty analysis. The ModClark model demonstrated good flood reproducibility regardless of the estimation method for spatial rainfall fields. Parameter estimation results indicated that the WREPN spatial rainfall field, which accounted for the influence of the mountain effect, led to lower curve numbers due to higher estimated rainfall compared to the IDW spatial rainfall field, while the concentration time and storage coefficient showed minimal differences.

The magnitude and frequency of extreme rainfall due to climate change is increasing. Increasing rainfall causes serious hydrological problems in cities. Rainfall does not infiltrate the soil, but mostly flows through the sewer pipes into the stream. Most old urban watersheds have combined sewer pipes. When rainfall exceeds the capacity of the combined sewer pipes, sewage mixed with stormwater overflows the sewer pipes and flows directly into the stream. This is called Combined Sewer Overflows (CSOs). CSOs enter the stream with non-point source pollutants accumulated on the surface and pollute the stream. CSOs are one of the major water quality problems in older urban watersheds. This can be solved by replacing the combined sewer pipes with separated sewer pipes, but in reality it requires astronomical costs. As an alternative, the Low Impact Development (LID) technique has recently been introduced. In this study, we analyzed the effects of climate change on CSOs in urban watersheds and applied LID techniques to offset the effects. The LID facility was applied with the most commonly used Bio-Retention cells.

Delving into cancer dormancy has been an inherent task that may drive the lethal recurrence of cancer after primary tumor relief. Cells in quiescence can survive for a short or long term in silence, may undergo genetic or epigenetic changes, and can initiate relapse through certain contextual cues. The state of dormancy can be induced by multiple conditions including cancer drug treatment, in turn, undergoes a life cycle that generally occurs through dissemination, invasion, intravasation, circulation, immune evasion, extravasation, and colonization. Throughout this cascade, a cellular machinery governs the fate of individual cells, largely affected by gene regulation. Despite its significance, a precise view of cancer dormancy is yet hampered. Revolutionizing advanced single cell and long read sequencing through analysis methodologies and artificial intelligence, the most recent stage in the research tool progress, is expected to provide a holistic view of the diverse aspects of cancer dormancy.

Using modelling approaches to predict stream flow from ungauged basins requires new model calibration strategies and evaluation methods that are different from the existing ones. Soil moisture information plays an important role in hydrological applications in basins. Increased availability of remote sensing data presents a significant opportunity to obtain the predictive performance of hydrological models (especially in ungauged basins), but there is still a limit to applying remote sensing soil moisture data directly to models. The Soil Moisture Active Passive (SMAP) satellite mission provides global soil moisture data estimated by assimilating remotely sensed brightness temperature to a land surface model. This study investigates the potential of a hydrological model calibrated using only global root zone soil moisture based on satellite observation when attempting to predict stream flow in ungauged basins. This approach’s advantage is that it is particularly useful for stream flow prediction in ungauged basins since it does not require observed stream flow data to calibrate a model. The modelling experiments were carried out on upstream watersheds of two dams in South Korea with high-quality stream flow data. The resulting model outputs when calibrated using soil moisture data without observed stream flow data are particularly impressive when simulating monthly stream flows upstream of the dams, and daily stream flows also showed a satisfactory level of predictive performance. In particular, the model calibrated using soil moisture data for dry years showed better predictive performance than for wet years. The performance of the model calibrated using soil moisture data was significantly improved under low flow conditions compared to the traditional regionalization approach. Additionally, the overall stream flow was also predicted better. In addition, the uncertainty of the model calibrated using soil moisture was not much different from that of the model calibrated using observed stream flow data, and showed more robust outputs when compared to the traditional regionalization approach. These results prove that the application of the global soil moisture product for predicting stream flows in ungauged basins is promising.

Many studies have applied the Long Short-Term Memory (LSTM), one of the Recurrent Neural Networks (RNNs), to rainfall-runoff modeling. These data-driven modeling approaches learn the patterns observed from input and output data. It is widely known that the LSTM networks are sensitive to the length and quality of observations used for learning. However, the discussion on a better composition of input data for rainfall-runoff modeling has not yet been sufficiently conducted. This study focuses on whether the composition of input data could help improve the performance of LSTM networks. Therefore, we first examined changes in streamflow prediction performance by various compositions of meteorological variables which are used for LSTM learning. Second, we evaluated whether learning by integrating data from all available basins can improve the streamflow prediction performance of a specific basin. As a result, using all available meteorological data strengthened the model performance. The LSTM generalized by the multi-basin integrated learning showed similar performance to the LSTMs separately learned for each basin but had more minor errors in predicting low flow. Furthermore, we confirmed that it is necessary to group by selecting basins with similar characteristics to increase the usefulness of the integrally learned LSTM.

As a significant portion of the available water resources in volcanic terrains such as Jeju Island are dependent on groundwater, reliable groundwater level forecasting is one of the important tasks for efficient water resource management. This study aims to propose deep-learning-based methods for groundwater level forecasting that can be utilized in actual management works and to assess their applicability. The study suggests practical forecasting methodologies through the Gyorae area of Jeju Island, where the groundwater level is highly volatile and unpredictable. To this end, the groundwater level data of the JH Gyorae-1 point and a total of 12 kinds of daily hydro-meteorological data from 2012 to 2021 were collected. Subsequently, five factors (i.e., mean wind speed, sun hours, evaporation, minimum temperature, and daily precipitation) were selected as hydro-meteorological data for groundwater level forecasting through cross-wavelet analysis between the collected hydro-meteorological data and groundwater level data. The study simulated the groundwater level of the JH Gyorae-1 point using the long short-term memory (LSTM) model, a representative deep-learning technique, with the selected data to show that the methodology is adequately applicable. In addition, for its better utilization in actual practice, the study suggests and analyzes (i) a derivatives-based groundwater level learning model which is defined as derivatives-based learning to forecast derivatives (gradients) of the groundwater level, not the target groundwater time series itself, and (ⅱ) an ensemble forecasting methodology in which groundwater level forecasting is performed repetitively with short time intervals.

Frequency regulation (FR) using a battery energy storage system (BESS) has been expanding because of the growth of renewable energy. This study introduces the wear density function, which considers battery degradation factors such as the rate of current, temperature, and depth of discharge (DOD) to provide a precise lifespan prediction. Furthermore, an equivalent system model is developed to evaluate the FR performance of the BESS for various operating parameters. Finally, a quantitative tradeoff relationship between performance and battery lifecycle is derived from the analysis using operational data of the actual BESS for FR.

In the context of hydrological model calibration, observational data play a central role in refining and evaluating model performance and uncertainty. Among the critical factors, the length of the data records and the associated climatic conditions are paramount. While there is ample research on data record length selection, the same cannot be said for the selection of data types, particularly when it comes to choosing the climatic conditions for calibration. Conceptual hydrological models inherently simplify the representation of hydrological processes, which can lead to structural limitations, which is particularly evident under specific climatic conditions. In this study, we explore the impact of climatic conditions during the calibration period on model predictive performance and uncertainty. We categorize the inflow data from AnDong Dam and HapCheon Dam in southeastern South Korea from 2001 to 2021 into four climatic conditions (dry years, normal years, wet years, and mixed years) based on the Budyko dryness index. We then use data from periods within the same climatic category to calibrate the hydrological model. Subsequently, we analyze the model’s performance and posterior distribution under various climatic conditions during validation periods. Our findings underscore the substantial influence of the climatic conditions during the calibration period on model performance and uncertainty. We discover that when calibrating the hydrological model using data from periods with wet climatic conditions, achieving comparable predictive performance in validation periods with different climatic conditions remains challenging, even when the calibration period exhibits excellent model performance. Furthermore, when considering model parameters and predicted streamflow uncertainty, it is advantageous to calibrate the hydrological model under dry climatic conditions to achieve more robust results.

River runoff predictions in ungauged basins are one of the major challenges in hydrology. In the past, the approach using a physical-based conceptual model was the main approach, but recently, a solution using a data-driven model has been evaluated as more appropriate through several studies. In this study, a new data-driven approach combining various recurrent neural networks and decision tree-based algorithms is proposed. An advantage of recurrent neural networks is that they can learn long-term dependencies between inputs and outputs provided to the network. Decision tree-based algorithms, combined with recurrent neural networks, serve to reflect topographical information treated as constants and can identify the importance of input features. We tested the proposed approach using data from 25 watersheds publicly available on the Korean government’s website. The potential of the proposed approach as a regional hydrologic model is evaluated in the view that one regional model predicts river runoff in various watersheds using the leave-one-out cross-validation regionalization setup.

Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (ASD), that are caused by multiple etiologies, including genetic heterogeneity, epigenetic dysregulation, and aberrant morphological and biochemical conditions. Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have been renewed as fascinating treatment options and have gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions of psychiatric disorders resulting from individuality, complex genetic interplay, and intricate neural circuits impact the systemic pharmacology of psychedelics, which disturbs the integration of mechanisms that may result in dissimilar medicinal efficiency. The precise prescription of psychedelic drugs remains unclear, and advanced approaches are needed to optimize drug development. Here, recent studies demonstrating the diverse pharmacological effects of psychedelics in mental disorders are reviewed, and emerging perspectives on structural function, the microbiota‐gut‐brain axis, and the transcriptome are discussed. Moreover, the applicability of deep learning is highlighted for the development of drugs on the basis of big data. These approaches may provide insight into pharmacological mechanisms and interindividual factors to enhance drug discovery and development for advanced precision medicine. Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.