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Investigators in China report the results of an open-label, randomized clinical trial of lopinavir–ritonavir for the treatment of Covid-19 in 199 infected adult patients. The primary end point was the time to clinical improvement.

Ge-containing Lewis acidic zeolites are typically synthesized using a conventional hydrothermal strategy from amorphous silica sources, through a long time- and energy-consuming approach limiting their wide applications. This study reports a rapid synthesis strategy for a series of IWV aluminogermanosilicate zeolites ( T- x -Al ) with a wide range of Si/Ge molar ratios (5–15) by interzeolite transformation of dealuminated FAU (DA-FAU). Notably, Ge-rich IWV could be obtained with crystallization time as short as one day by the equimolecular Si/Ge ratio gel. The effect of synthetic parameters was investigated and the obtained T- x -Al samples were characterized by XRD, SEM, EDS, ICP, 29 Si and 27 Al MAS NMR, FTIR, and N 2 physisorption analyses. Compared with a previously reported IWV germanosilicate (H-3), T- x -Al displayed a better catalytic activity in Baeyer-Villiger (BV) oxidation, attributed to the presence of the active framework Ge sites with the assistance of the extra-framework Al species. The cyclic catalysis tests revealed that the presence of framework Al species contributed to the stability of the T- x -Al . Specifically, T- x -Al , with 14-membered ring (MR) supercages, outperformed the typical 12-MR Sn-beta catalyst in the BV oxidation of large ketone-like 2-admantanone, indicating a promising potential application in the macromolecular catalytic process.

This study proposes an improved stiffness ellipsoid method to enhance the stiffness and precision of robotic arms in friction stir welding (FSW) operations. The method involves establishing a joint stiffness model through static identification experiments and developing a novel stiffness index derived from the improved stiffness ellipsoid method. This index provides a refined metric for evaluating the robot’s performance under variable loads during FSW. Simulation experiments demonstrate significant improvements in welding trajectory precision and computational efficiency. The findings highlight the potential of this method to elevate FW quality and consistency.

This study reports the first complete mitochondrial genome assembly of Hippophae salicifolia, an ecologically and economically important plant endemic to the Himalayas. The 475,105 bp genome has a 44.80% GC content and an overall AT bias, comprising 74 genes (37 protein-coding, 31 tRNA, three rRNA, and three pseudogenes). We identified extensive repetitive elements, including 188 SSRs, 20 tandem repeats, and 455 dispersed repeats, and explored their potential roles in genome evolution. Codon usage analysis showed a bias for codons ending in A or U, while RNA editing analysis revealed 415 sites that mostly convert hydrophilic to hydrophobic amino acids. Phylogenetic and collinearity analyses clarified evolutionary relationships within Hippophae and uncovered genome rearrangements. In addition, extensive gene transfer was detected between the mitochondrial and chloroplast genomes. Ka/Ks and nucleotide diversity analyses indicate that most genes are under purifying selection, with some possibly undergoing positive selection. Overall, these findings enhance our understanding of the structural and evolutionary features of the H. salicifolia mitochondrial genome and provide valuable insights for the genetic improvement and conservation of Hippophae species.

T-cell acute lymphoblastic leukemia (T-ALL) represents an area of highly unmet medical needs. Once relapsed, patients have limited treatment options and poor prognosis. T-ALL antigens such as CD7 is extensively expressed in normal T cells and natural killer (NK) cells, and extending the success of CAR-T therapy to T cell malignancies was challenged by CAR-T cell fratricide, high production cost, and potential product contaminations. GC027 is an “off-the-shelf” allogeneic CD7 targeted CAR-T therapeutic product for T cell malignancies. It demonstrated superior cell expansion and antileukemia efficacy in mouse xenograft model. In our previous study, we observed promising efficacy results in the first two relapsed and refractory(R/R) T-ALL patients treated with GC027. In the expanded study, 11 out of 12 patients had rapid eradication of T-lymphoblasts and reached complete response within 1-month after GC027 infusion. GC027 cells expanded quickly beginning at infusion and reached to peak around 5–10 days after infusion. For most patients with a response(9/11), GC027 could not be detected via flow cytometry or qPCR 4 weeks after infusion. One patient had progression free survival of >3 years. With manageable toxicity profile, GC027 demonstrated superior clinical efficacy to standard chemotherapy regimens in (R/R) T cell malignancies.

As a clean energy, Liquefied Petroleum Gas (LPG) is consistent with the coordinated and sustainable development of both the economy and environment. However, LPG is a hazardous material (hazmat) and is thus always transported in cylinders by vehicles on urban road networks to meet varying demand. This transport can threaten the surrounding citizens, vehicles, and even the whole urban area. Hence, LPG transportation should be focused on maintaining its security while simultaneously minimizing shipping costs. When LPG is moved through an urban area, its threat level fluctuates with the network congestion level, which continually varies by different time periods. So, variation in the magnitude of the threat posed by LPG transportation causes additional changes in the safe-related cost as well as the shipping cost. This study aims to solve the problem of an LPG transportation operation on an urban road network according to congested periods; the solution is based on cutting its two types of cost. In general, we should choose an LPG transport period that results in a lower safety cost, however optimization of an LPG transportation operation must minimize both the safety cost and shipping cost. This paper presents the problem of LPG flow distribution and vehicle dispatch scheme by “period-security” to rationalize the LPG transport risk level. Firstly, the impedance function of LPG flow distribution was constructed with a focus on the safety cost in different periods. Meanwhile, a bi-level programming model was built, in which the upper mixed binary integer programming model aims to minimize the shipping cost and the lower model is a user-equilibrium model that is aimed at calculating the distribution of the LPG demands on the given lines and in feasible periods. Then, we designed a heuristic algorithm based on the Genetic Algorithm to solve the upper model and embedded the Frank-Wolfe Algorithm to get the optimal LPG flow distribution solution. Numerical examples are presented which validate that the LPG optimal operation can realize a minimal safety cost and the minimum shipping cost for three LPG demand values by considering the congestion situation.