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IntroductionGestational diabetes mellitus (GDM) is one of the most common health complications during pregnancy. Medical nutrition therapy is the mainstay of treatment for GDM, however, there is no current consensus on optimal dietary approaches to prevent or control hyperglycaemia in pregnancy. The aim of this systematic review is to assess the relationships between plant-based dietary patterns, plant foods and botanical dietary supplements with GDM and maternal glycaemic biomarkers.Methods and analysisA predefined search strategy was used on 16 June 2021, to search PubMed, Embase and CINAHL Plus with Full Text (EBSCOhost), as well as ClinicalTrials.gov, for studies published as original articles in English. Articles will be included if they are human observational studies or clinical trials and will be excluded if they are review articles or conference abstracts. We will use Cochrane’s risk of bias tools for interventions that are parallel arm (Risk of Bias tool for randomised trials version 2 (RoB 2)) and single arm, non-randomised intervention studies (Risk of Bias In Non-randomised Studies-of Interventions (ROBINS-I)). For observational, case–control and cross-sectional studies, we will use the National Heart, Lung and Blood Institute’s quality assessment tools. Data will be synthesised in a narrative format describing significant results as well as presenting the results of the quality assessment of studies.Ethics and disseminationThis systematic review does not require ethical approval as primary data will not be collected. The review will be published in a peer-reviewed journal and disseminated electronically and in print.PROSPERO registration numberCRD42022306915.

This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge® analysis. Data were analyzed using Spearman’s correlation analysis and the Mann–Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = −0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = −0.897, p = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed.

Cancer survivors suffer from multiple symptoms, including fatigue, pain, insomnia symptoms, and cognitive dysfunction. Exercise, especially a personalized program, may relieve symptoms and improve overall well-being. While many personalized exercise interventions were face-to-face, most interventions transitioned to telehealth visits during the C OVID-19 pandemic. Further studies are needed to determine the efficacy of virtual interventions in comparison to in-person ones. This study compares the effect of a telehealth personalized exercise program on fatigue, pain, cognitive function, insomnia, self-efficacy, and well-being compared to an in-person personalized exercise program. A secondary data analysis was conducted on two 12-week randomized control pilot studies (JHM-IRB00154198 and IRB00175781) for solid tumor cancer survivors. The hrst study involved face-to-face home visits with phone follow-ups for exercise recommendations. The second employed a completely virtual approach and weekly exercise recommendations via a smartphone app. Symptoms (e.g., fatigue, pain, cognitive function, and sleep), self-efficacy, and well-being were measured at baseline and completion of the 12-week program. Analysis using SPSS involved a paired t-test for intervention effects and ANCOVA for group differences, adjusting for age. A total of 75 participants who completed the program were included in this analysis. Fifteen participants received in-person personalized exercise, 39 were in telehealth personalized exercise, and 21 were in usual care control. After 12 weeks, No significant differences in symptoms at program completion compared to baseline between the face-to-face and telehealth groups. The study supports the effectiveness of personalized exercise programs on fatigue and sleep. Additionally, the findings suggest the effectiveness of this program on symptoms was compatible between in-person and telehealth visits. Healthcare providers should consider telehealth-based interventions as viable alternatives to in-person visits, especially when direct interactions are challenging. Despite these strengths, this study is limited by its small sample size, which can constrain the generalization of the findings. It is essential to conduct further research with a larger cohort to ascertain the long-term effects.

Patients with cancer commonly experience a variety of symptoms, both physically and mentally including fatigue, pain, sleep disturbance, depression, and anxiety etc. Acupressure has gained recognition in clinical and community practice. However, there is a need for more empirical support for its potential benefits in alleviating cancer-related symptoms. Objectives were to examine the effect of a 12-week acupressure intervention on multiple symptoms in cancer patients. This is a secondary data analysis of a pilot randomized controlled trial (JHM - IRB00154198) that examined the feasibility and compared the effects of 12-week combined non-pharmacological interventions on cancer-related symptoms among solid tumor cancer patients aged 21 or older. For this report, we included participants in the acupressure intervention and control groups. Cancer-related symptoms were measured using PROMIS-29 and Insomnia Severity Index (ISI). Descriptive analysis using STATA was conducted to examine changes in symptoms before and after the intervention. A total of 29 acupressure or control group participants were enrolled (mean age 56.8 ± 11.6, age range 33-74) and completed the study. The majority were white (n=23,79.3%) and participants with breast cancer diagnosed (n=i2, 41.4%). A total of 22 participants (75.9%) received acupressure treatment. Among participants who received acupressure, 36.4% of participants reported improvement in physical function, 31.8% in anxiety, 36.4% in depression, 45.5% in fatigue and 40.9% in sleep disturbance. Additionally, the average change in self-reported fatigue was decreased by 7% from baseline. This secondary analysis provides initial evidence to support the potential benefit of acupressure on multiple physical symptoms in cancer survivors including fatigue, sleep disturbance, pain intensity depression and anxiety. The result of this study is limited due to a small sample size and the nature of patient's self-reported outcomes. Larger sample size and additional measures of each symptom should be included and investigated in future studies.

Background/Objectives: This study evaluates the effects of a personalized exercise program on symptoms (pain, fatigue, sleep, cognitive function, physical function), resilience, and health-related quality of life (HRQOL) and compares the effectiveness of in-person versus telehealth delivery. Methods: A secondary data analysis was conducted on two 12-week randomized control pilot studies for solid tumor cancer survivors. One study involved in-person home visits with telephone follow-ups. The second utilized weekly exercise recommendations via a smartphone app. Both studies had control participants who received the standard care. Symptoms, resilience, and HRQOL were measured at baseline and after 12 weeks. Paired t-tests were conducted for intervention effects and ANCOVA for group differences, adjusting for age and education. Results: The analysis included 75 program completers: 15 in-person (iHBE), 38 telehealth (TEHE), and 22 who received standard care. Those receiving exercise interventions reported improvements in physical (t = 3.0, p < 0.01) and mental fatigability (t = 3.1, p < 0.01) at program completion compared to baseline. Comparing the mean changes between participants receiving exercise interventions in-person and via telehealth, there were no significant differences between the two delivery methods except perceived visuo-perceptual cognitive difficulty (F = 3.55, p = 0.027), where telehealth showed a slight advantage. Conclusions: The study provides initial evidence of the effectiveness of a telehealth personalized exercise on fatigability and cognitive difficulty, suggesting it is a potential viable alternative to in-person intervention. Further research with a larger cohort is essential to ascertain the effects of these interventional modalities on cancer-related health outcomes.