Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
219,395
result(s) for
"Jing, Jing"
Sort by:
Fake Chinese sounds
\"Between homework, studying, and Chinese school, Měi Yīng's summer is shaping up to be a boring one. Her only bright spots are practice with her soccer team, the Divas, and the time spent with her năi nai, who is visiting from Taiwan. Although Měi Yīng's Mandarin isn't the best and Năi Nai doesn't speak English, they find other ways to connect, like cooking guōtiē together and doing tai chi in the mornings. By the end of the summer, Měi Yīng is sad to see Năi Nai go-she's the complete opposite of Měi Yīng serious professor mother-but excited to start fifth grade. Until new kid Sid starts making her the butt of racist jokes. Her best friend, Kirra, says to ignore him, but does everyone else's silence about the harassment mean they're also ignoring Sid . . . or her? As Sid's bullying fuels Měi Yīng's feelings of invisibility, she must learn to reclaim her identity and her voice.\"--Back cover.
Book
CHML promotes liver cancer metastasis by facilitating Rab14 recycle
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
Metastasis-associated recurrence is a major cause of poor prognosis in hepatocellular carcinoma. Here, the authors show that expression of choroideremia-like (CHML) is elevated and associates with poor prognosis in hepatocellular carcinoma, and mechanistically CHML promotes metastasis in a Rab14-dependent manner.
Journal Article
Consumer economic wellbeing
\"This timely text overviews theories, concepts, and contexts relating to the emerging field of behavioral economics. Research theories and data gathered across psychology, sociology, marketing, finance, and other relevant disciplines are synthesized to identify and elaborate on the defining aspects of consumer economic wellbeing. Against a background of consumer rights and responsibilities, the book discusses consumer phenomena of earning, spending, saving, and borrowing and their contributions to improving (and in some cases to worsening) economic wellness. In addition, the author presents effective ways consumers can be encouraged to navigate key economic environments such as the media, advertising, and the internet, and to change negative financial behaviors\"--Publisher's description.
Book
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers
Background
Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN family members, and diagnosis as well as the prognosis of digestive tract cancers.
Methods
Oncomine and Ualcan were used to analyze PTPN expressions. Data from The Cancer Genome Atlas (TCGA) were downloaded through UCSC Xena for validation and to explore the relationship of the PTPN expression with diagnosis, clinicopathological parameters and survival of digestive tract cancers. Gene ontology enrichment analysis was conducted using the DAVID database. The gene–gene interaction network was performed by GeneMANIA and the protein–protein interaction (PPI) network was built using STRING portal coupled with Cytoscape. The expression of differentially expressed PTPNs in cancer cell lines were explored using CCLE. Moreover, by histological verification, the expression of four PTPNs in digestive tract cancers were further analyzed.
Results
Most PTPN family members were associated with digestive tract cancers according to Oncomine, Ualcan and TCGA data. Several PTPN members were differentially expressed in digestive tract cancers. For esophageal carcinoma (ESCA), PTPN1 and PTPN12 levels were correlated with incidence; PTPN20 was associated with poor prognosis. For stomach adenocarcinoma (STAD), PTPN2 and PTPN12 levels were correlated with incidence; PTPN3, PTPN5, PTPN7, PTPN11, PTPN13, PTPN14, PTPN18 and PTPN23 were correlated with pathological grade; PTPN20 expression was related with both TNM stage and N stage; PTPN22 was associated with T stage and pathological grade; decreased expression of PTPN5 and PTPN13 implied worse overall survival of STAD, while elevated PTPN6 expression indicated better prognosis. For colorectal cancer (CRC), PTPN2, PTPN21 and PTPN22 levels were correlated with incidence; expression of PTPN5, PTPN12, and PTPN14 was correlated with TNM stage and N stage; high PTPN5 or PTPN7 expression was associated with increased hazards of death. CCLE analyses showed that in esophagus cancer cell lines, PTPN1, PTPN4 and PTPN12 were highly expressed; in gastric cancer cell lines, PTPN2 and PTPN12 were highly expressed; in colorectal cancer cell lines, PTPN12 was highly expressed while PTPN22 was downregulated. Results of histological verification experiment showed differential expressions of PTPN22 in CRC, and PTPN12 in GC and CRC.
Conclusions
Members of PTPN family were differentially expressed in digestive tract cancers. Correlations were found between PTPN genes and clinicopathological parameters of patients. Expression of PTPN12 was upregulated in both STAD and CRC, and thus could be used as a diagnostic biomarker. Differential expression of PTPN12 in GC and CRC, and PTPN22 in CRC were presented in our histological verification experiment.
Journal Article
كيف اختفينا /
الاختفاء هنا لم يكن فقط عن البلاد التي تعرضت للإباده الجماعيه حتي تختفي معالمها من علي وجه الأرض، البعد الأهم الذي ركزت عليه الكاتبه في الروايه كان عن إختفاء قصص النساء من الرواية المعترف بها في الكتب المدرسية والبرامج والروايات حينما يتم الحديث عن معاناة تلك الفتره وكأن هناك اتفاق جمعي علي تجاهل ما حدث للنساء وما تعرضن له من قهر واعتداء جنسي بأن يتحولن الي أداة متعه لجنود المحتل الياباني في الفتره بين عامي 1942 و1945 أثناء الحرب العالمية الثانيه أو كما أطلق عليهن \"فتيات المتعة\" وهو المصطلح المهذب للإغتصاب والإعتداء الجنسي الذي حدث لنساء الدول التي احتلتها اليابان في تلك الفتره بإجبار النساء علي تقديم الخدمات الجنسية مقابل وجبة ساخنة أو تجنبا للضرب والتعذيب والموت جوعا. الأغرب أنه كانت هناك حالة جماعيه من الإختفاء الإختياري لما تعرضت له النساء حيث اختارت نساء تلك البلاد إخفاء العنف الجنسي الذي تعرضن له فالأهم أن لا يعرف أحد أنهن تعرضن للإغتصاب حتي لا يعرضن نفسهن للعار والإدانه لبقية حياتهن. وتظل بطلة الروايه تتذكر نصيحة أمها في الليله السابقه لزفافها : (تذكري لا تخبري أحدا بما حدث لا أحد وخصوصا زوجك) وتظل الحكايات مختفيه حتي تقرر بعض الجدات أن يروين قصصهن فكانت تلك الرواية.
Book
Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis
Recurrence and metastasis remain the major obstacles to successful treatment of hepatocellular carcinoma (HCC). Chromatin remodeling factor ARID2 is commonly mutated in HCC, indicating its important role in cancer development. However, its role in HCC metastasis is largely elusive. In this study, we find that ARID2 expression is significantly decreased in metastatic HCC tissues, showing negative correlation with pathological grade, organ metastasis and positive association with survival of HCC patients. ARID2 inhibits migration and invasion of HCC cells in vitro and metastasis in vivo. Moreover, ARID2 knockout promotes pulmonary metastasis in different HCC mouse models. Mechanistic study reveals that ARID2 represses epithelial–mesenchymal transition (EMT) of HCC cells by recruiting DNMT1 to Snail promoter, which increases promoter methylation and inhibits Snail transcription. In addition, we discover that ARID2 mutants with disrupted C2H2 domain lose the metastasis suppressor function, exhibiting a positive association with HCC metastasis and poor prognosis. In conclusion, our study reveals the metastasis suppressor role as well as the underlying mechanism of ARID2 in HCC and provides a potential therapeutic target for ARID2-deficient HCC.
Journal Article
Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) Analysis for the Identification of Pathogenic Microorganisms: A Review
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been used in the field of clinical microbiology since 2010. Compared with the traditional technique of biochemical identification, MALDI-TOF MS has many advantages, including convenience, speed, accuracy, and low cost. The accuracy and speed of identification using MALDI-TOF MS have been increasing with the development of sample preparation, database enrichment, and algorithm optimization. MALDI-TOF MS has shown promising results in identifying cultured colonies and rapidly detecting samples. MALDI-TOF MS has critical research applications for the rapid detection of highly virulent and drug-resistant pathogens. Here we present a scientific review that evaluates the performance of MALDI-TOF MS in identifying clinical pathogenic microorganisms. MALDI-TOF MS is a promising tool in identifying clinical microorganisms, although some aspects still require improvement.
Journal Article
Selective functionalization of methane, ethane, and higher alkanes by cerium photocatalysis
The methane, ethane, and propane in natural gas are mostly inert under ambient conditions. Mainly they are burned to produce heat. Hu et al. show that a simple cerium salt paired with an alcohol can catalytically transform these and other simple hydrocarbons into reactive radicals at room temperature (see the Perspective by Kanai). The reactions rely on light to photolytically cleave cerium alkoxide bonds, producing alkoxy radicals that strip H atoms from the hydrocarbons and regenerate the alcohol. The resultant alkyl radicals readily add to azo compounds, olefins, and aromatics. Science , this issue p. 668 ; see also p. 647 Photolysis of cerium alkoxides forms alkoxy radicals that strip H atoms from hydrocarbons to produce reactive alkyl radicals. With the recent soaring production of natural gas, the use of methane and other light hydrocarbon feedstocks as starting materials in synthetic transformations is becoming increasingly economically attractive, although it remains chemically challenging. We report the development of photocatalytic C–H amination, alkylation, and arylation of methane, ethane, and higher alkanes under visible light irradiation at ambient temperature. High catalytic efficiency (turnover numbers up to 2900 for methane and 9700 for ethane) and selectivity were achieved using abundant, inexpensive cerium salts as photocatalysts. Ligand-to-metal charge transfer excitation generated alkoxy radicals from simple alcohols that in turn acted as hydrogen atom transfer catalysts. The mixed-phase gas/liquid reaction was adapted to continuous flow, enabling the efficient use of gaseous feedstocks in scalable photocatalytic transformations.
Journal Article