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Built for growth : how builder personality shapes your business, your team, and your ability to win
Many factors shape the success or failure of a new business, whether it's a stand-alone start-up or a new venture inside a larger corporation. But the most important and least understood of these factors is the personality of the builder--the founder or leader's particular combination of beliefs and preferences that drives his or her motivation, decision making, and leadership style. And it's the one factor you, as a business builder yourself, can directly control. This book decodes the interplay between builder personality and new business success or failure. Using a patented analytic methodology, authors Chris Kuenne and John Danner discovered four distinct types of highly successful \"business builder\" personalities--the Driver, the Explorer, the Crusader, and the Captain--each displaying special gifts and predictable gaps or shortcomings in growing their companies and new ventures. Built for Growth blends exclusive research findings, personal interviews, and experienced analysis to illustrate how each type handles the five dynamic challenges of building businesses of lasting value: converting an idea into reality, recruiting inspired talent, transforming buyers into partners, aligning financial and other supporters, and scaling the business. With vivid stories and practical tools, this book gives you unprecedented insight into the personalities of each Builder Type and how you can use that insight to assess yourself and others and improve your odds of success. Built for Growth is the ultimate guide for how to play to your strengths, complement and compensate for your gaps, and build successful businesses--from start-up to scale-up.-- Provided by publisher.
Book
The Role of Myeloid-Derived Cells in the Progression of Liver Disease
Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to maintain tissue architecture. Studies in humans and rodents have revealed a heterogeneous population of myeloid cells that respond to the local environment by either promoting regeneration or driving the inflammatory processes that can lead to hepatitis, fibrogenesis, and the development of cirrhosis and malignancy. Such plasticity of myeloid cell responses presents unique challenges for therapeutic intervention strategies and a greater understanding of the underlying mechanisms is needed. Here we review the role of myeloid cells in the establishment and progression of liver disease and highlight key pathways that have become the focus for current and future therapeutic strategies.
Journal Article
Accretion and Outflow in Orion-KL Source I
We present Atacama Large Millimeter/submillimeter Array observations of SiO, SiS, H2O, NaCl, and SO line emission at ∼30–50 mas resolution. These images map the molecular outflow and disk of Orion Source I (SrcI) on ∼12–20 au scales. Our observations show that the flow of material around SrcI creates a turbulent boundary layer in the outflow from SrcI, which may dissipate angular momentum in the rotating molecular outflow into the surrounding medium. Additionally, the data suggest that the proper motion of SrcI may have a significant effect on the structure and evolution of SrcI and its molecular outflow. As the motion of SrcI funnels material between the disk and the outflow, some material may be entrained into the outflow and accrete onto the disk, creating shocks that excite the NaCl close to the disk surface.
Journal Article
Swarm intelligence unravels the confinement effects for tiny noble gas clusters within carbon nanotubes
Inspired by the myriad manifestations of confinement effects for atoms and molecules encapsulated within carbon nanotubes (CNTs), herein, we explore the role of the physical dimensions of the CNTs in controlling the optimal configurations of confined noble gas clusters. We utilize the particle swarm optimization (PSO) technique together with the continuum approximation for CNTs to arrive at the minimum energy configurations of the encapsulated He, Ne and Ar clusters in the size range 2–10. The ease with which a global search technique such as PSO can track down the minima on complex potential energy surfaces within reasonable computational times enables probing a wide spectrum of CNTs covering nanotubes with lengths in the 10–50 Å range and possessing radii of 3–6 Å. Our findings indicate a strong correlation between the most stable cluster configuration and the physical dimensions of the CNT within which it is confined. Notably, the confined cluster geometries encompass linear, zigzag and spiral configurations, in striking contrast to their isolated geometries. Guided by the chemical intuition, we have further expanded the search space and examined the possibility of exohedral binding in necessary cases. The implementation of the PSO along with the continuum approximation can generate excellent starting geometries amenable for further analysis using highly accurate first-principles calculations.
Journal Article
The final hurdle : single best answers in clinical pharmacology and therapeutics
This book focuses on reinforcing core concepts, improving exam technique and developing confidence in answering the style of questions used in the examinations.
Book
Quantitative Ethnobotany and Species Use Patterns in Ngao Model Forest, Northern Thailand
Understanding how ecological dominance aligns with culturally and economically valued plant use is critical for participatory forest management. This study integrated vegetation structure and ethnobotanical valuation to assess angiosperm importance across three forest strata (Mixed Deciduous Forest (MDF), Dry Dipterocarp Forest site 1 (DDF1), and Dry Dipterocarp Forest site 2 (DDF2)) within the Ngao Model Forest, Northern Thailand. Fifteen 10 × 10 m vegetation plots (five per forest stratum) were surveyed to calculate the Importance Value Index (IVI), and 198 semi-structured interviews were conducted to derive the Use Value Index (UVI) and a standardized Socio-Economic Value Index (SEVI). A total of 112 angiosperm species were recorded across forest types, with strong structural dominance by dipterocarps in DDF sites and greater compositional heterogeneity in MDF. Spearman rank correlation analysis supported the working hypothesis that ecological dominance is only weakly associated with cultural and socio-economic importance. IVI showed weak but significant positive correlations with UVI (ρ = 0.288, p < 0.05) and SEVI (ρ = 0.300, p < 0.05), indicating partial but limited alignment between structural abundance and livelihood value. Several species with moderate or low IVI exhibited disproportionately high UVI and SEVI scores, reflecting their importance in food, medicinal, and commercial use categories. Conversely, certain canopy dominants showed limited ethnobotanical significance. These findings demonstrate that ecological abundance alone is an insufficient proxy for community-defined species value. Integrating structural, cultural, and socio-economic indices provides a more comprehensive framework for identifying priority species in community-managed forest systems. The IVI–UVI–SEVI comparative approach offers practical insights for model forest governance by distinguishing ecological dominants, multipurpose livelihood species, and culturally significant taxa occurring outside forest interiors. This multidimensional valuation framework strengthens participatory forest management and biodiversity prioritization in heterogeneous tropical landscapes.
Journal Article
Change of seasons : a memoir
\"John Oates was born at the perfect time, paralleling the birth of rock and roll. Raised in a small Pennsylvania town, he was exposed to folk, blues, soul, and R & B. After he met and teamed up with Daryl Hall in the late 1960s, they developed a style of music that was uniquely their own, but never abandoned their roots. In his memoir, John uncovers the grit and struggle it took to secure a recording contract with legendary Atlantic Records, and chronicles the artistic twists and turns that resulted in a DJ discovering an obscure album track that would become their first hit record\"--Back cover.
Book
Collaborative case-based learning with programmatic team-based assessment: a novel methodology for developing advanced skills in early-years medical students
Background
Imperial College London launched a new, spiral undergraduate medical curriculum in September 2019. Clinical & Scientific Integrative cases (CSI) is an innovative, flagship module, which uses pioneering methodology to provide early-years learning that [1] is patient-centred, [2] integrates clinical and scientific curriculum content, [3] develops advanced team-work skills and [4] provides engaging, student-driven learning. These aims are designed to produce medical graduates equipped to excel in a modern healthcare environment.
Methods
CSI has adopted a novel educational approach which utilises contemporary digital resources to deliver a collaborative case-based learning (CBL) component, paired with a team-based learning (TBL) component that incorporates both learning and programmatic assessment. This paper serves to explore how first-year students experienced CSI in relation to its key aims, drawing upon quantitative and qualitative data from feedback surveys from CSI’s inaugural year. It provides a description and analysis of the module’s design, delivery, successes and challenges.
Results
Our findings indicate that CSI has been extremely well-received and that the majority of students agree that it met its aims. Survey outputs indicate success in integrating multiple elements of the curriculum, developing an early holistic approach towards patients, expediting the development of important team-working skills, and delivering authentic and challenging clinical problems, which our students found highly relevant. Challenges have included supporting students to adapt to a student-driven, deep learning approach.
Conclusions
First-year students appear to have adopted a patient-centred outlook, the ability to integrate knowledge from across the curriculum, an appreciation for other team members and the self-efficacy to collaboratively tackle challenging, authentic clinical problems. Ultimately, CSI’s innovative design is attractive and pertinent to the needs of modern medical students and ultimately, future doctors.
Journal Article