Explore the vast range of titles available.

The investigation of low Reynolds number flows is crucial, particularly for applications such as wind turbines and small-scale UAVs. This study compares the owl airfoil with the NACA0012 and hawk airfoils through wind tunnel testing, utilizing pressure sensors and force balance to examine the aerodynamic noise sources and aerodynamic performance of the airfoils. A total of six airfoils were investigated at various Reynolds numbers from 44 × 10 3 to 160 × 10 3 , considering the glide flight envelop for various owl species. Wind tunnel test results showed higher Cl and L/D ratio for the owl airfoil, outperforming the NACA0012 and hawk airfoils by up to 6.7% and 44.1%, respectively. This is attributed to the optimal camber of the owl airfoil compared to the two other airfoils, and its lower relative thickness too. This helps flight with this airfoil at lower AOA, which reduces noise. In addition, the stall angle for owl airfoil was ranging from 8° to 15° higher than NACA0012 airfoil, which stalled at 10°-11°, and higher than 6° to 12° hawk stall angle. This feature allowed owls to perform efficient flights in glide phase at lower AOA that minimized the main aerodynamic noise sources such as the separations and pressure fluctuations. Pressure measurements represented the initiation of LSB for the owl airfoil at around AOA = 6° to 10° at different Reynolds numbers, while the hawk airfoil shown the presence of LSB starting from AOA = 0°. A detailed analysis of the pressure fluctuations showed that the owl airfoil had fewer sources of aerodynamic noise, such as LSB, stall phenomena, and separated shear layers, on both its upper and lower surfaces, compared to other types of airfoils. Additionally, an analysis in the frequency domain showed that the amplitude of FFT for NACA0012 and hawk airfoil is generally higher compared with the owl airfoil. These findings shed light on the aerodynamic characteristics and noise generation mechanisms of owl airfoil for future research and design considerations.

The relationship between heavy metal exposure and risk of osteopenia or osteoporosis has biological plausibility, yet it remains inconclusive; therefore, we conducted a systematic review and meta-analysis to evaluate the associations between exposure to heavy metals (i.e., cadmium, lead, and mercury) and the risk of osteopenia or osteoporosis. Databases of MEDLINE, Embase, Scopus, and Web of Science were searched through November 2019, to identify studies that evaluated the relationship between exposure to cadmium, lead, and mercury and risk of osteopenia or osteoporosis in adults. Fourteen eligible studies were included. Effect sizes expressed as pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated using weighted random-effect models. Exposure to cadmium (OR = 1.35; 95% CI: 1.17 to 1.56; P ≤ 0.001) and lead (OR = 1.15; 95% CI: 1.00 to 1.32; P = 0.05) was associated with an increased risk of osteopenia or osteoporosis, unlike mercury. Subgroup analyses showed cadmium exposure increased the risk of osteopenia or osteoporosis in older (> 65 yrs.; OR = 1.43; 95%CI: 1.08 to 1.88, P = 0.01) compared with younger (18-65 yrs.; OR = 1.24; 95% CI: 1.02 to 1.52, P = 0.03) adults. Also, lead exposure increased the risk in men (OR = 1.55; 95% CI: 1.15 to 2.09, P = 0.007) unlike in women. By contrast to urinary levels, blood (OR = 1.26; 95% CI: 1.08 to 1.47, P = 0.003) and dietary (OR = 1.46; 95% CI: 1.28 to 1.67, P < 0.001) levels of cadmium were associated with an increased risk of osteopenia or osteoporosis. Exposure to cadmium and lead may be associated with an increased risk of osteopenia or osteoporosis, although high heterogeneity was detected.

The potential for manipulating characteristics of skyrmions in a CrI 3 monolayer using circularly polarised light is explored. The effective skyrmion-light interaction is mediated by bright excitons whose magnetization is selectively influenced by the polarization of photons. The light-induced skyrmion dynamics is illustrated by the dependencies of the skyrmion size and the skyrmion lifetime on the intensity and polarization of the incident light pulse. Two-dimensional magnets hosting excitons thus represent a promising platform for the control of topological magnetic structures by light.

The incidence of cardiovascular diseases (CVD) is increased in rheumatoid arthritis (RA) patients. It remains unclear whether the load of RA increases cardiovascular (CV) risk especially in female and in younger RA patients. In the present study we aim to analyse the influence of age and gender on CV risk in RA relative to the general population, using meta-analysis of direct comparative studies. Systematic literature search was performed in MEDLINE for studies reporting on occurrence of CV events in RA as compared to the general population, stratified for gender and/or age. Quality was appraised using the Newcastle-Ottawa scale. Meta-analysis was performed on rate ratios using inverse variance methods. There were 1372 records screened and 13 studies included. RA females and males have a similar higher risk (95%CI) to develop stroke with RR 1.35 (1.30-1.40) and RR 1.31 (1.21-1.43); coronary artery disease with RR 1.65 (1.54-1.76) versus RR 1.55 ((1.41-1.69) in men; cardiovascular disease with RR 1.56 (1.49-1.62) versus 1.50 (1.41-1.60). The highest incidence of CV events was observed in the youngest patients, RR 2.59 (1.77-3.79), whereas older patients had the lowest relative risk when compared to the general population, RR 1.27 (1.16-1.38). The relative risk of RA patients for CVD is age dependent, but does not depend on gender: the relative risk on CVD appears to be equally raised for males and females, while relatively young RA patients (<50 years) have the highest, and older patients the lowest relative risk.

The present study aimed to evaluate the effects of different supplemental fat sources (soyabean oil (SBO) as a source of n-6 fatty acid (FA) and fish oil (FO) as a source of n-3 FA) in the starter feed of milk-fed dairy calves during the hot season. Forty Holstein calves (3 d of age; 39·67 kg of body weight; ten calves per group) were randomly assigned to the experimental treatments as follows: (1) starter feed supplemented with no fat source (CON), (2) starter feed supplemented with 3 % SBO (DM basis), (3) starter feed supplemented with 3 % FO (DM basis) and (4) starter feed supplemented with an equal mixture of SBO and FO (1·5 % each, DM basis). The milk feeding schedule was constant for treatments and all calves were weaned on day 65 of age. Results show that calves had greater starter intake, average daily gain and body length when fed SBO compared with the other treatments. However, feed efficiency was increased and inflammatory indicators (TNF-α, serum amyloid A and haptoglobin) concentrations were reduced in the calves fed FO compared with the other treatments. In summary, it was revealed that SBO rich in n-6 FA improved starter intake and growth performance, while FO rich in n-3 FA could improve the immune function of calves. Due to the current experimental condition, an equal mixture of SBO and FO (1·5 % each, DM basis) can be recommended to have an optimum growth performance and immune function while the calves are reared under the heat conditions.

This study was conducted to investigate the effects of supplementation of different fat sources in calf starters on growth performance, health, blood fatty acid profiles, and inflammatory markers during the cold season in dairy calves. A total of 48 Holstein calves (24 males and 24 females) were randomly assigned to 1 of 4 starter diets throughout the experiment (d 3 to 65): (1) no supplemented fat (CON), (2) 3% calcium-salts of soybean oil (Ca-SBO), (3) 3% calcium-salts of fish oil (Ca–FO), and (4) 3% mixture of Ca-SBO and Ca–FO (1.5% each, DM basis; MIX). Calves were given free access to starter feed and water and were raised individually in pens from 3 to 65 d of age. Calves fed Ca-SBO consumed a greater proportion of n-6 FA, while calves fed Ca–FO consumed a greater level of n-3 FA compared to the other dietary treatments. Fat supplementation increased the intake of linoleic acid, the major n-6 FA, with the greater intake observed in the Ca-SBO group compared to the other dietary treatments. Calves fed the Ca–FO and MIX diets consumed more long-chain n-3 FA than the other diets. In addition, calves fed Ca-SBO and Ca–FO diets consumed more starter feed and total dry matter than calves fed MIX and CON throughout the experiment (d 3 to 65). Calves fed Ca–FO had higher average daily gain throughout the trial (d 3 to 65) than the other treatment groups. Of all treatment groups, calves fed Ca–FO achieved the highest final body weight and showed the greatest feed efficiency. Random forest analysis revealed that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid were the serum levels of FA most affected by the diets. The principal component analysis of blood FA profile, blood parameters, and inflammatory markers showed distinct differences between dietary treatments. Calves fed Ca-SBO had higher plasma concentrations of linoleic acid, while calves fed Ca–FO had higher plasma concentrations of long-chain n-3 polyunsaturated fatty acids (PUFA), such as EPA, docosapentaenoic acid (DPA), and DHA than the other treatment groups. Plasma inflammatory markers were lower in calves fed Ca–FO and higher in calves fed CON than in the other treatment groups. The Ca–FO group had lower levels of inflammatory markers, including serum amyloid A, tumor necrosis factor-alpha, Interferon-γ, haptoglobin, and interleukin-6 compared to the other experimental treatments. Also, the blood malondialdehyde levels, an indicator of oxidative stress, were lower in calves fed Ca–FO compared with calves fed the other treatment diets. In conclusion, the performance of preweaned dairy calves can be improved by adding fat to their starter feed under cold conditions. Overall, the type of fat in milk may affect growth and inflammation of dairy calves before weaning under cold conditions, with n-3 FA (Ca–FO) promoting growth and reducing inflammation more effectively than n-6 FA (Ca-SBO).

In the current research, different configurations of wing-equipped diffusers at the rear of the standard Ahmed body were investigated to identify the optimal model for drag reduction and downforce enhancement. The investigations were conducted at Reynolds numbers ranging from 0.33×106 to 2.01×106. Initially, the optimal diffuser is found to be 10°, achieving significant reductions in drag and increases in downforce. Thereafter, a rectangular wing with a high-cambered airfoil was integrated into the diffuser region in eight different configurations, varying in angle of attack and horizontal and vertical positioning. The configuration with the wing at 10° angle of attack and positioned vertically at 1/4 of the underbody height and horizontally at the beginning of the diffuser demonstrated the most desirable aerodynamic performance regarding drag reduction. The second case, with the wing at 10° angle of attack and positioned vertically at 1/2 of the underbody height and horizontally at the end of the diffuser, achieved the most desirable aerodynamic performance regarding downforce enhancement.

Colorectal cancer (CRC) is the third leading cause of cancer-related death and has an extremely poor prognosis. Dysregulation of microRNAs (miRNAs) has been shown to be involved in the pathogenesis and progression of many malignancies. Recent data suggest that microRNA-21 (miR-21) is significantly elevated in different types of cancer, especially colon adenocarcinoma. Against this background, locked nucleic acid (LNA)-modified oligonucleotides have recently been suggested as a novel approach for targeting miRNAs as antisense-based gene silencing. The aim of the current study was to explore the functional role of LNA-anti-miR-21 in a colon adenocarcinoma LS174T cell line. LS174T cells were transfected with LNA-anti-miR-21 for 24, 48 and 72 h. Quantitative real-time reverse transcriptase-PCR (qRT-PCR) was performed to assess miR-21 expression by LNA-anti-miR-21. The viability of the cells was evaluated by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay and Annexin V/propidium iodide staining assay was used to detect apoptosis. Moreover, invasive behavior of the cells was evaluated before and after therapy by transwell assay. LNA-anti-miR-21 was successfully transfected in human LS174T cells and suppressed the endogenous miR-21. LNA-anti-miR-21 inhibited the cells' growth followed by induction of apoptosis. LNA-anti-miR-21 (50 pmol/μl) reduced the invasive behaviors of LS174T cells after 24 h, compared with untreated cells and scrambled LNA-transfected cells. However, this effect was more pronounced after 72 h. Our findings suggest the therapeutic potential of LNA-anti-miR-21 in a colon adenocarcinoma for targeting miR-21 expression. Further studies are warranted to investigate the molecular mechanisms underlying this novel inhibitor in colorectal cancer to establish its potential value for treatment of CRC patients with high miR-21 expression.

By giving a brief definition and example of Kenmotsu-like statistical manifolds, we investigate the geometry of invariant submanifolds of Kenmotsu-like statistical manifolds. We show that invariant submanifolds of these manifolds inherit Kenmotsu-like and Kaehler-like structure if the characteristic vector field be tangent and normal, respectively. Moreover, we prove that in tangent case, the submanifold is a statistical minimal submanifold.

The potential for manipulating characteristics of skyrmions in a CrI$$_3$$3 monolayer using circularly polarised light is explored. The effective skyrmion-light interaction is mediated by bright excitons whose magnetization is selectively influenced by the polarization of photons. The light-induced skyrmion dynamics is illustrated by the dependencies of the skyrmion size and the skyrmion lifetime on the intensity and polarization of the incident light pulse. Two-dimensional magnets hosting excitons thus represent a promising platform for the control of topological magnetic structures by light.