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\"Investigative reporter Nora Hesper spends her nights cloaked in shadows. As Indigo, she's become an urban myth, a brutal vigilante who can forge darkness into weapons and travel across the city by slipping from one patch of shadow to another. Her primary focus both as Nora and as Indigo has become a murderous criminal cult called the Children of Phonos. Children are being murdered in New York, and Nora is determined to make it stop, even if that means Indigo must eliminate every member. But in the aftermath of a bloody battle, a dying cultist makes claims that cause Indigo to question her own origin and memories\"-- Provided by publisher.

This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1981.

These collaborative stories unite two beloved characters from two different urban fantasy series in each of ten electrifying new stories.

While many studies have shown the benefits of later school starts, including better student attendance, higher test scores, and improved sleep duration, few have used starting times later than 9:00 a.m. Here we report on the implementation and impact of a 10 a.m. school start time for 13 to 16-year-old students. A 4-year observational study using a before-after-before (A-B-A) design was carried out in an English state-funded high school. School start times were changed from 8:50 a.m. in study year 0, to 10 a.m. in years 1-2, and then back to 8:50 a.m. in year 3. Measures of student health (absence due to illness) and academic performance (national examination results) were used for all students. Implementing a 10 a.m. start saw a decrease in student illness after 2 years of over 50% ( < 0.0005 and effect size: Cohen's = 1.07), and reverting to an 8:50 a.m. start reversed this improvement, leading to an increase of 30% in student illness ( < 0.0005 and Cohen's = 0.47). The 10:00 a.m. start was associated with a 12% increase in the value-added number of students making good academic progress (in standard national examinations) that was significant (<0.0005) and equivalent to 20% of the national benchmark. These results show that changing to a 10:00 a.m. high school start time can greatly reduce illness and improve academic performance. Implementing school start times later than 8:30 a.m., which may address the circadian delay in adolescents' sleep rhythms more effectively for evening chronotypes, appears to have few costs and substantial benefits.

This paper analyses the effect of income inequality on Europeans' quality of life, specifically on their overall well-being (happiness, life satisfaction), on their financial quality of life (satisfaction with standard of living, affordability of goods and services, subjective poverty), and on their health (self-rated health, satisfaction with health). The simple bivariate correlations of inequality with overall well-being, financial quality of life, and health are negative. But this is misleading because of the confounding effect of a key omitted variable, national economic development (GDP per capita): Unequal societies are on average much poorer (r = 0.46) and so disadvantaged because of that. We analyse the multi-level European Quality of Life survey conducted in 2003 including national-level data on inequality (Gini coefficient) and economic development (GDP) and individual-level data on overall well-being, financial quality of life, and health. The individual cases are from representative samples of 28 European countries. Our variance-components multi-level models controlling for known individual-level predictors show that national per capita GDP increases subjective well-being, financial quality of life, and health. Net of that, the national level of inequality, as measured by the Gini coefficient, has no statistically significant effect, suggesting that income inequality does not reduce well-being, financial quality of life, or health in advanced societies. These result all imply that directing policies and resources towards inequality reduction is unlikely to benefit the general public in advanced societies.

In the last decade advances in human neuroscience have identified the critical importance of time in creating long-term memories. Circadian neuroscience has established biological time functions via cellular clocks regulated by photosensitive retinal ganglion cells and the suprachiasmatic nuclei. Individuals have different circadian clocks depending on their chronotypes that vary with genetic, age, and sex. In contrast, social time is determined by time zones, daylight savings time, and education and employment hours. Social time and circadian time differences can lead to circadian desynchronization, sleep deprivation, health problems, and poor cognitive performance. Synchronizing social time to circadian biology leads to better health and learning, as demonstrated in adolescent education. In-day making memories of complex bodies of structured information in education is organized in social time and uses many different learning techniques. Research in the neuroscience of long-term memory (LTM) has demonstrated in-day time spaced learning patterns of three repetitions of information separated by two rest periods are effective in making memories in mammals and humans. This time pattern is based on the intracellular processes required in synaptic plasticity. Circadian desynchronization, sleep deprivation, and memory consolidation in sleep are less well-understood, though there has been considerable progress in neuroscience research in the last decade. The interplay of circadian, in-day and sleep neuroscience research are creating an understanding of making memories in the first 24-h that has already led to interventions that can improve health and learning.

To ensure consistent performance of additively manufactured metal parts, it is advantageous to identify alloys that are robust to process variations. This paper investigates the effect of steel alloy composition on mechanical property robustness in laser-directed energy deposition (L-DED). In situ blending of ultra-high-strength low-alloy steel (UHSLA) and pure iron powders produced 10 compositions containing 10–100 wt% UHSLA. Samples were deposited using a novel configuration that enabled rapid collection of hardness data. The Vickers hardness sensitivity of each alloy was evaluated with respect to laser power and interlayer delay time. Yield strength (YS) and ultimate tensile strength (UTS) sensitivities of five select alloys were investigated in a subsequent experiment. Microstructure analysis revealed that cooling rate-driven phase fluctuations between lath martensite and upper bainite were a key factor leading to high hardness sensitivity. By keeping the UHSLA content ≤20% or ≥70%, the microstructure transformed primarily to ferrite or martensite, respectively, which generally corresponded to improved robustness. Above 70% UHSLA, the YS sensitivity remained low while the UTS sensitivity increased. This finding, coupled with the observation of auto-tempered martensite at lower cooling rates, may suggest a strong response of the work hardening capability to auto-tempering at higher alloy contents. This work demonstrates a methodology for incorporating robust design into the development of alloys for additive manufacturing.

How tightly linked are the strength of a country’s welfare state and its residents’ support for income redistribution? Multilevel model results (with appropriate controls) show that the publics of strong welfare states recognize their egalitarian income distributions, i.e., the stronger the welfare state, the less the actual and perceived inequality; but they do not differ from their peers in liberal welfare states/market-oriented societies in their preferences for equality. Thus, desire for redistribution bears little overall relationship to welfare state activity. However, further investigation shows a stronger relationship under the surface: Poor people’s support for redistribution is nearly constant across levels of welfarism. By contrast, the stronger the welfare state, the less the support for redistribution among the prosperous, perhaps signaling “harvest fatigue” due to paying high taxes and longstanding egalitarian policies. Our findings are not consistent with structuralist/materialist theory, nor with simple dominant ideology or system justification arguments, but are partially consistent with a legitimate framing hypothesis, with an atomistic self-interest hypothesis, with a reference group solidarity hypothesis, and with the “me-and-mine” hypothesis incorporating sociotropic and egotropic elements. Database: the World Inequality Study: 30 countries, 71 surveys, and over 88,0000 individuals.

Rationale Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is a retrograde neuronal messenger that participates in synaptic plasticity, including late-phase long-term potentiation (LTP) and long-term memory (LTM) formation. Our recent studies have shown that nNOS knockout (KO) mice have a severe deficit in contextual fear conditioning compared to wild type (WT) counterparts (Kelley et al. 2009 ). Objectives Given the role of the nNOS gene in fear conditioning, we investigated whether systemic administration of modulators of NO signaling affect the formation of contextual and cued fear memories and the effects of these modulators on cyclic 3′5′-guanosine monophosphate (cGMP) levels in the hippocampus and amygdala. Methods The preferential nNOS inhibitor S-methyl- l -thiocitrulline (SMTC; 10–200 mg/kg) was administered (IP) to WT mice, and the NO donor molsidomine (10 mg/kg) was administered (IP) to nNOS KO mice either 30 min pretraining or immediately posttraining. Results Pretraining SMTC administration to WT mice impaired both short- and long-term memories of contextual (36% inhibition) but not cued fear conditioning. Pretraining molsidomine administration to nNOS KO mice improved their deficit in short- and long-term memories of contextual fear conditioning (46% increase). Posttraining drug administration had no effect on WT and nNOS KO mice. The systemic administration of SMTC dose-dependently decreased cGMP concentrations down to 25% of control, while molsidomine increased cGMP concentration (three- and five-fold) in amygdala and hippocampus, respectively. Conclusions These findings suggest that neuronal NO and its downstream second messenger cGMP are important for acquisition and subsequent consolidation of LTM of contextual fear conditioning.

Introduction Radioligand imaging is a powerful in vivo method to assess the molecular basis of Alzheimer's Disease. We therefore aimed to visualize the pathological deposition of fibrillar amyloid-[beta] and neuronal dysfunction in aged double transgenic mice. Methods Using non-invasive positron emission tomography (PET) we assessed brain glucose utilization with [.sup.18F]FDG and fibrillar amyloidosis with [.sup.11C]PiB and [.sup.18F]AV45 in 12 month old APPPS1-21 (n = 10) mice and their age-matched wild-type controls (n = 15). PET scans were analyzed with statistical parametric mapping (SPM) to detect significant differences in tracer uptake between genotypes. After imaging, mice were sacrificed and ex vivo measures of amyloid-[beta] burden with immunohistochemistry as well as glucose utilization with [.sup.14C]-2DG autoradiography were obtained as gold standards. Results Voxel-wise SPM analysis revealed significantly decreased [.sup.18F]FDG uptake in aged APPPS1-21 mice in comparison to WT with the thalamus (96.96 %, maxT = 3.35) and striatum (61.21 %, maxT = 3.29) demonstrating the most widespread reductions at the threshold of p < 0.01. [.sup.11C]PiB binding was significantly increased in APPPS1-21 mice, most notably in the hippocampus (87.84 %, maxT = 7.15) and cortex (69.08 %, maxT = 7.95), as detected by SPM voxel-wise analysis at the threshold of p < 0.01. Using the same threshold [.sup.18F]AV45 uptake was comparably lower with less significant differences. Compared to their respective ex vivo equivalents [.sup.18F]FDG demonstrated significant positive correlation to [.sup.14C]2-DG autoradiography (r = 0.67, p <0.0001) while [.sup.11C]PiB and [.sup.18F]AV45 binding did not correlate to ex vivo immunohistochemistry for amyloid-[beta] (r = 0.25, p = 0.07 and r = 0.17, p = 0.26 respectively). Lastly no correlation was observed between regions of high amyloid burden and those with decreased glucose utilization (r = 0.001, p = 0.99). Conclusions Our findings support that fibrillar amyloid-[beta] deposition and reduced glucose utilization can be visualized and quantified with in vivo [mu]PET imaging in aged APPPS1-21 mice. Therefore, the combined use of [.sup.18F]FDG and amyloid [mu]PET imaging can shed light on the underlying relationship between fibrillar amyloid-[beta] pathology and neuronal dysfunction.