Explore the vast range of titles available.

Individuals who are unable to walk independently spend most of the day in a wheelchair. This population is at high risk for developing pressure injuries caused by sitting. However, early diagnosis and prevention of these injuries still remain challenging. Herein, we introduce battery-free, wireless, multimodal sensors and a movable system for continuous measurement of pressure, temperature, and hydration at skin interfaces. The device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity, a temperature sensor for measuring skin temperature, and a galvanic skin response sensor for measuring skin hydration levels. The movable system enables power harvesting, and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body coverage. Experimental evaluations and numerical simulations of the devices, together with clinical trials for wheelchair patients, demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.

Xylose‐rich undefined broth, extracted from the dilute acid pretreatment wastes of barley straw, serves as resourceful media for Acremonium chrysogenum M35 culture and production of cephalosporin C (CPC). Concentrating the extract with proper reprocessing enables to prepare various concentrations of xylose broth (2%–8%). The undefined xylose media were prepared for CPC production from A. chrysogenum M35 by the addition of other nutrients. Cell growth and CPC production were the most effective at 6% xylose and additional 2% glycerol, with maximum CPC production of 9.07 g/L after 6 days, which is higher production than that in defined media prepared with laboratory‐level nutrients and reagents. Investigation of autotrophic and reverse trans‐sulfuration pathways for cysteine synthesis, a limited element of three precursors for CPC synthesis, supports the enhanced CPC production in undefined media. Abundance of xylose ensures a maintained NADPH concentration required for sulfate reduction and synthesis of amino sulfide such as cysteine. Cystathionine‐γ‐lyase activity profiling indicated more efficient biosynthesis in undefined media than in other cultures use glycerol and glucose, and the biosynthesis pathway of CPC production by the cephalosporin gene cluster (i.e. pcbC and cefG genes) was investigated. The process using undefined xylose media was designed, and process simulation program confirmed our results. Biorefinery byproducts, or wastes, can be utilized as a carbon source of microorganism. The use of the wastes could improve the economics of biorefinery, while simultaneously enhancing the environmental sustainability of the biorefinery process.

Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.

The purpose of the present study is to test whether symbol grounding for action verbs occurs in entrenched native verb forms, and whether they transfer to novel verb forms that are acquired as explicit translations of existing verbs. The entrenched and novel verbs were referred to here as L1 verbs and L2 verbs respectively, and were used as analogs of meanings in first and second language learning. Symbolic grounding was investigated by observing behavioral data in lexical decision tasks, and scalp electrophysiological signals using 128-channel EEG data. The present study used different kinds of action verbs (e.g., verbs of foot movement, such as kick or jump, and verbs of hand movement, such as swipe or grab) and abstract verbs, such as learn or plan. Previous researchers have provided empirical evidence showing that when action verbs are accessed in reading, there is concomitant activation of primary motor and/or somatosensory cortex. The established relationships of action verbs in L1 and their sensorimotor groundings as a reference were used to determine successful transfer of groundings of L1 words to L2 words. By observing the responses to the L2 words that are acquired through symbolic manipulation without perceptual or bodily experiences and examining, it can be determined if they produce similar neural activations as in those found in L1 words, and we can test whether the symbol-grounding-transfer occurs in part or in whole, given this minimal learning context. The behavioral measure was a lexical decision task where the participants respond to meaningful words (foot-related verbs or hand-related verbs) with two kinds of response modalities (button press with a finger or foot pedal press with a foot). Although either facilitation (foot verb to foot movement and hand verb to hand movement) or interference (Foot verb to hand movement and hand verb to foot movement) effect of action verbs was expected, the results showed that the participants consistently responded faster to the L1 English verbs than to the L2 verbs and responded faster with finger-pressing button box than foot-pressing pedal. However, at the slowest response times condition, the condition of foot-pedal pressing to L2 words, the facilitation effect of Foot related verbs was observed. The response times of foot pedal pressing to L2 Foot-related verbs were significantly faster than both L2 Hand-related verbs (p=.003) and abstract verbs (p=.005) at the paired t-test. This result is consistent with the research hypothesis and provides partial evidence supporting the assumption that the Foot-related action verbs have close link with sensorimotor cortex associated with foot movement and reading those verbs will facilitate corresponding body movement. The three kinds of EEG data analysis methods were used in the current study: Event Related Potential (ERP) component analysis, EEG topographic analysis, and EEG source localization with low resolution brain electromagnetic tomography (LORETA). The ERP components were used to examine the effect of language (L1 vs. L2) and lexicality (Word vs. Non-word) in terms of amplitudes and temporal points of ERP components. The EEG topographic analysis and EEG source localization with LORETA are methods for spatiotemporal analysis, which provide information on intracranial neural activations that are sources of scalp electric signals. When ERP components of the montaged electrodes placed on the central area of the scalp (vertex and neighboring 14 electrodes) were examined, the P3 component for L1 (at around 390∼400ms) reached its peak earlier that that of L2 (495∼505ms). Topographic analysis results that compared topographic maps created by different verb groups provided evidence that different configurations of the neuronal activations were created by the verb groups representing body movements of different body parts. In addition, by means of the source localization analysis with the LORETA, the differential neural activations at sensorimotor cortex were observed when the brain activations elicited by L1 Foot related and Hand related verbs were compared. At both temporal windows, early (126∼134ms) and late (318∼322ms), the regions of the sensorimotor cortex associated with Hand movement were activated significantly more by the Hand related verbs than Foot related verbs. In order to test Harnad's symbol grounding transfer hypothesis, the neural activations at the sensorimotor cortex elicited by L2 Foot verbs and the L2 Hand verbs were examined in comparison with those of the abstract verbs. Significant larger activations were elicited by both of the action verbs over the abstract verbs. To summarize, the current study provided the neurophysiological evidence on the symbol grounding at L1 word and the symbol grounding transfer at L2 words by exhibiting links between the regions of sensorimotor cortex and L1 and L2 action verbs in terms of differential neural activations elicited by the verb groups.

We have designed a tunneling source follower (TSF) for image sensors that achieves high voltage gain ( A v ) and low 1/ f noise simultaneously. The TSF is composed of N-P-N-N, especially the p-doped grounded area, which serves to amplify the insufficient tunneling current, allowing the source follower (SF) to utilize band-to-band tunneling (BTBT). Compared to thermionic emission, tunneling based structures contribute to increasing A v through lower channel length modulation and lower body effect. As a result, TSF achieves a higher A v (~ 1.0 V/V) than conventional SF (~ 0.9 V/V). Moreover, the n-doped channel makes the buried conductive channel farther from the interface, lowering the noise. The input-referred voltage noise spectral density ( S V ) is approximately 10 times lower in TSF than that of in conventional SF. Therefore, our TSF can be a possible candidate for High A v and low 1/ f noise image sensors.

Decreased total CO 2 (tCO 2 ) is significantly associated with all-cause mortality in critically ill patients. Because of a lack of data to evaluate the impact of tCO 2 in patients with COVID-19, we assessed the impact of tCO 2 on all-cause mortality in this study. We retrospectively reviewed the data of hospitalized patients with COVID-19 in two Korean referral hospitals between February 2020 and September 2021. The primary outcome was in-hospital mortality. We assessed the impact of tCO 2 as a continuous variable on mortality using the Cox-proportional hazard model. In addition, we evaluated the relative factors associated with tCO 2  ≤ 22 mmol/L using logistic regression analysis. In 4,423 patients included, the mean tCO 2 was 24.8 ± 3.0 mmol/L, and 17.9% of patients with tCO 2  ≤ 22 mmol/L. An increase in mmol/L of tCO 2 decreased the risk of all-cause mortality by 4.8% after adjustment for age, sex, comorbidities, and laboratory values. Based on 22 mmol/L of tCO 2 , the risk of mortality was 1.7 times higher than that in patients with lower tCO 2 . This result was maintained in the analysis using a cutoff value of tCO 2 24 mmol/L. Higher white blood cell count; lower hemoglobin, serum calcium, and eGFR; and higher uric acid, and aspartate aminotransferase were significantly associated with a tCO 2 value ≤ 22 mmol/L. Decreased tCO 2 significantly increased the risk of all-cause mortality in patients with COVID-19. Monitoring of tCO 2 could be a good indicator to predict prognosis and it needs to be appropriately managed in patients with specific conditions.

Our previous studies have shown that supplementation of low-dose antibiotic growth promoter (AGP) exacerbated growth performance and systemic inflammation of weaned pigs infected with pathogenic Escherichia coli (E. coli). The objective of this experiment, which is extension of our previous report, was to investigate the effect of low-dose AGP on gene expression in ileal mucosa of weaned pigs experimentally infected with F18 E. coli. Thirty-four pigs (6.88 ± 1.03 kg BW) were individually housed in disease containment rooms and randomly allotted to one of three treatments (9 to 13 pigs/treatment). The three dietary treatments were control diet (control), and 2 additional diets supplemented with 0.5 or 50 mg/kg of AGP (carbadox), respectively. The experiment lasted 18 d [7 d before and 11 d after first inoculation (d 0)]. The F18 E. coli inoculum was orally provided to all pigs with the dose of 1010 cfu/3 mL for 3 consecutive days. Total RNA [4 to 6 pigs/treatment on d 5; 5 to 7 pigs/treatment on 11 post-inoculation (PI)] was extracted from ileal mucosa to analyze gene expression profiles by Batch-Tag-Seq. The modulated differential gene expression were defined by 1.5-fold difference and a cutoff of P < 0.05 using limma-voom package. All processed data were statistically analyzed and evaluated by PANTHER classification system to determine the biological process function of genes in these lists. Compared to control, supplementation of recommended-dose AGP down-regulated genes related to inflammatory responses on d 5 and 11 PI; whereas, feeding low-dose AGP up-regulated genes associated with negative regulation of metabolic process on d 5, but down-regulated the genes related to immune responses on d 11 PI. The present observations support adverse effects of low-dose AGP in our previous study, indicated by exacerbated the detrimental effects of E. coli infection on pigs’ growth rate, diarrhea and systemic inflammation.

Our previous studies have shown that supplementation of low-dose antibiotic growth promoter (AGP) exacerbated growth performance and systemic inflammation of weaned pigs infected with pathogenic Escherichia coli (E. coli). The objective of this experiment, which is extension of our previous report, was to investigate the effect of low-dose AGP on gene expression in ileal mucosa of weaned pigs experimentally infected with F18 E. coli. Thirty-four pigs (6.88 ± 1.03 kg BW) were individually housed in disease containment rooms and randomly allotted to one of three treatments (9 to 13 pigs/ treatment). The three dietary treatments were control diet (control), and 2 additional diets supplemented with 0.5 or 50 mg/kg of AGP (carbadox), respectively. The experiment lasted 18 d [7 d before and 11 d after first inoculation (d 0)]. The F18 E. coli inoculum was orally provided to all pigs with the dose of 1010 cfu/3 mL for 3 consecutive days. Total RNA [4 to 6 pigs/treatment on d 5; 5 to 7 pigs/treatment on 11 post-inoculation (PI)] was extracted from ileal mucosa to analyze gene expression profiles by Batch-Tag-Seq. The modulated differential gene expression were defined by 1.5-fold difference and a cutoff of P < 0.05 using limma-voom package. All processed data were statistically analyzed and evaluated by PANTHER classification system to determine the biological process function of genes in these lists. Compared to control, supplementation of recommended-dose AGP down-regulated genes related to inflammatory responses on d 5 and 11 PI; whereas, feeding low-dose AGP up-regulated genes associated with negative regulation of metabolic process on d 5, but down-regulated the genes related to immune responses on d 11 PI. The present observations support adverse effects of low-dose AGP in our previous study, indicated by exacerbated the detrimental effects of E. coli infection on pigs' growth rate, diarrhea and systemic inflammation.

Introduction Regdanvimab, a neutralising monoclonal antibody (mAb) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), received approval for the treatment of coronavirus disease 2019 (COVID-19) in South Korea in 2021. The Ministry of Food and Drug Safety in South Korea mandate that new medications be re-examined for safety and effectiveness post-approval in at least 3000 individuals. This post-marketing surveillance (PMS) study was used to evaluate the safety and effectiveness of regdanvimab in real-world clinical care. Methods This prospective, multicentre, phase 4 PMS study was conducted between February 2021 and March 2022 in South Korea. Eligible patients were aged ≥ 18 years with confirmed mild COVID-19 at high risk of disease progression or moderate COVID-19. Patients were hospitalised and treated with regdanvimab (40 mg/kg, day 1) and then monitored until discharge, with a follow-up call on day 28. Adverse events (AEs) were documented, and the COVID-19 disease progression rate was used to measure effectiveness. Results Of the 3123 patients with COVID-19 infection identified, 3036 were eligible for inclusion. Approximately 80% and 5% of the eligible patients were diagnosed with COVID-19 during the delta- and omicron-dominant periods, respectively. Median (range) age was 57 (18–95) years, and 50.6% of patients were male. COVID-19 severity was assessed before treatment, and high-risk mild and moderate COVID-19 was diagnosed in 1030 (33.9%) and 2006 (66.1%) patients, respectively. AEs and adverse drug reactions (ADRs) were experienced by 684 (22.5%) and 363 (12.0%) patients, respectively. The most common ADR was increased liver function test ( n  = 62, 2.0%). Nine (0.3%) patients discontinued regdanvimab due to ADRs. Overall, 378 (12.5%) patients experienced disease progression after regdanvimab infusion, with extended hospitalisation/re-admission ( n  = 300, 9.9%) as the most common reason. Supplemental oxygen was required by 282 (9.3%) patients. Ten (0.3%) patients required intensive care monitoring and 3 (0.1%) died due to COVID-19. Conclusion This large-scale PMS study demonstrated that regdanvimab was effective against COVID-19 progression and had an acceptable safety profile when used in real-world clinical practice.