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"Klein, J R"
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Global business
In the wake of the Brexit vote and the election of Donald Trump, globalization has found itself increasingly under the microscope. An active international discussion is underway, and the ideological viewpoint that the reversal of globalization and a return to protectionism and isolation will cure the world's ills is touted by many. In the midst of the growing prominence of international interconnectivity and contradicting attention attained by skewed misinformation about global impact, Global Business is a straightforward commentary on mega trends in globalization. With insights and observations from academics, practitioners, and practical thinkers from around the world, Global Business demystifies the economic, social, and cultural impacts of globalism and globalization, and presents a balanced explanation of what is happening and how it affects everyone. It highlights that technology and change are not new, and explores the path taken to reach our current interconnected global state. It encourages a realistic examination of where we are and invites a dialogue on where we can go together. -- From dust jacket.
Book
Private finance for adaptation: do private realities meet public ambitions?
The private sector’s role in climate finance is increasingly subject to political and scientific debate. Yet there is poor empirical evidence of private engagement in adaptation and its potential contribution to the industrialised countries’ mobilisation of USD 100 billion of annual climate finance from 2020 onwards to support developing countries to address climate change. This paper analysed 101 case studies of private sector adaptation under the Private Sector Initiative (PSI) of the UNFCCC Nairobi work programme, and examined these against ten ‘adaptation finance criteria’ that were distilled from UN climate negotiation outcomes. Results show that private adaptation interventions complement public adaptation activities. Yet the ten adaptation finance criteria are not met, which demonstrates that the diplomatic UNFCCC conceptualisation of financing adaptation is dissonant from the private sector reality. For example, while the case studies’ investments are ‘new and additional’ to Official Development Assistance (ODA), their ‘predictability’ remains unclear. And despite some commitment for ‘up-scaling’, plans and associated costs for doing so remain undisclosed. Developed countries’ role in ‘mobilising’ private financial resources under the PSI seems limited. It is unrealistic to expect that the UNFCCC alters existing criteria to suit private initiatives, or that the private sector aligns its initiatives to meet existing criteria. This paper advocates monitoring and reporting only of those private investments that principally finance adaptation. This practical way forward would allow private finance to meet criteria such as predictability, transparency, and mobilisation, but would drastically reduce the amount of private investment that could contribute to reaching the USD 100 billion climate finance target.
Journal Article
Batman, Knightsend
\"Bruce Wayne returns to Gotham City only to find that his replacement, Jean-Paul Valley, has become increasingly violent and reckless. Now he must confront and defeat Jean-Paul in order to win back the mantle of the Bat. Following the events of Batman: Knightquest: The Search, Bruce Wayne is ready to return to his role as Gotham's greatest protector, Batman. Including never-before-collected material! Bruce Wayne completes his improbable recovery from his broken back and is ready to resume his role as Gotham's protector. But Jean-Paul Valley, the man who now patrols the night as a vicious and violent Batman, is not willing to give up his new identity. Driven to the brink of madness by inner demons, the new Batman seeks to destroy Bruce as they meet in mortal combat.\"-- Provided by publisher.
Book
Biogas Purification by Methane and Acetate Manufacturing
Wastewater treatment plants have two persistent financial and energetic drains, the carbon dioxide content of biogas, which limits its commercial sale, and the presence of trace organics in the wastewater effluent, which damages the aquatic ecosystem, like the Great Barrier Reef. Biogas is a renewable methane resource that is underutilized due to the variable CO2 content (~40%). Biogas is energy intensive to purify and limited by the economy of scale (> 8.85 GJ/h) to large‐scale purification methods, thus small‐scale processes require development. Electrocatalytic microbes native to wastewater have been shown to convert CO2 to CH4 and acetate, however complete conversion of the CO2 content to CH4 is energy intensive. Here we show a low power bioelectrochemical fuel cell design to purify biogas to pipeline quality methane (98%), manufacture methane and/or acetate, and remove trace organics, using HCO3− as the transport charge carrier from dissolved CO2 from the biogas through an anion exchange membrane. This decreased the power required to separate CO2 from methane in biogas on a molar basis, resulting in a net energy recovery similar to current industrial systems. Magnesium anode use resulted in an energy positive system. Tests evaluated the influence of cathode potential on the current density, HCO3− ion flux and the rates and efficiencies of methane production, resulting in optimization at −0.7 V versus standard hydrogen electrode (SHE). A techno‐economic analysis modeled a positive return on investment for scaled‐up production to purify small biogas streams that are otherwise financially unrecoverable. Carbon sequestration by production of methane, acetate and solid fertilizers demonstrated profitable and energy efficient waste‐to‐resource conversion. Methane is manufactured from carbon dioxide simultaneous to biogas purification for carbon neutral energy production in a biological fuel cell during the final process step of wastewater treatment. Lab tests demonstrate proof of concept during wastewater treatment. The techno‐economic analysis (financial and manufacturing model) demonstrates industrial scale operation can make a profit at manufacturing renewable methane and/or acetate.
Journal Article
Batman Knightfall omnibus
\"This classic storyline that led to the birth of a new Batman begins as the Dark Knight's greatest enemies have all simultaneously escaped from Arkham Asylum and are preying on Gotham City. With his city under siege, Batman pushes his body to its physical breaking point as he takes on the Joker, the Mad Hatter, Poison Ivy, Killer Croc, the Riddler and the Scarecrow, one after another. But things get much worse, when Bane, the man behind all of this madness, confronts an exhausted Batman and cripples him by breaking his back.\"-- Provided by publisher.
Book
Roquin—a multifunctional regulator of immune homeostasis
Roquin-1 (
Rc3h1
) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice. A single base-pair mutation in the
Rc3h1
gene resulted in the manifestation of autoantibody production and sustained immunological inflammation characterized by excessive T follicular helper cell activation and formation of germinal centers. Subsequent studies have uncovered a multifactorial process by which Roquin-1 contributes to the maintenance of immune homeostasis. Through its interactions with partner proteins, Roquin-1 targets mRNAs for decay with inducible costimulator being a primary target. In this review, we discuss newly discovered functions of Roquin-1 in the immune system and inflammation, and in disease manifestation, and discuss avenues of further research. A model is presented for the role of Roquin in health and disease.
Journal Article
Genetic architecture of prostate cancer in the Ashkenazi Jewish population
Background:
Recently, numerous prostate cancer risk loci have been identified, some of which show association in specific populations. No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population.
Methods:
A total of 29 known prostate cancer risk SNPs were genotyped in 963 prostate cancer cases and 613 controls of AJ ancestry. These data were combined with data from 1241 additional Ashkenazi controls and tested for association with prostate cancer. Correction for multiple testing was performed using the false discovery rate procedure.
Results:
Ten of twenty-three SNPs that passed quality control procedures were associated with prostate cancer risk at a false discovery rate of 5%. Of these, nine were originally discovered in studies of individuals of European ancestry. Based on power calculations, the number of significant associations observed is not surprising.
Conclusion:
We see no convincing evidence that the genetic architecture of prostate cancer in the AJ population is substantively different from that observed in other populations of European ancestry.
Journal Article
Adaptation decision-making in the Nordic countries: assessing the potential for joint action
In a global context, the outlook for the Nordic region is relatively favourable, given its relatively stronger resiliency to climate change impacts in comparison to many other geo-political regions of the world. Overall, the projected climatic changes include increases in mean temperatures and in precipitation, although regional variations can be significant. The countries’ robust institutions and economies give them a strong capacity to adapt to these changes. Still, the need for adaptation to the changing climate has been and still is substantial, and in most of the region, there has been progress on the issue. This paper explores the potential for Nordic cooperation on adaptation; specifically, for the development of a regional adaptation strategy. In particular, it addresses two questions (1) What is the current state of adaptation in the Nordic countries? and (2) What are the potential benefits and weaknesses of a Nordic strategy for adaptation? In order to answer these two questions, this paper examines reviews the current national adaptation policies of each Nordic country and discusses the challenges facing a Nordic strategy and finally assesses the potential for common Nordic adaptation policy and further cooperation.
Journal Article
An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality
Background:
Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.
Methods:
We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.
Results:
Seven SNPs showed associations on multivariable analysis (
P
<0.05), rs13385191 with both biochemical recurrence (BR) and castrate metastasis (CM), rs339331 (BR), rs1894292, rs17178655 and rs11067228 (CM), and rs11902236 and rs4857841 PCa-specific mortality. After applying a Bonferroni correction for number of SNPs (
P
<0.0008), the only persistent significant association was between rs17632542 (
KLK3
) and PSA levels at diagnosis (
P
=1.4 × 10
−5
).
Conclusions:
We confirmed that rs17632542 in
KLK3
is associated with PSA at diagnosis. No significant association was seen between loci and disease-specific end points when accounting for multiple testing. This provides further evidence that known PCa risk SNPs do not predict likelihood of disease progression.
Journal Article
Creation and functionalization of defects in SiC by proton beam writing
Proton beam writing (PBW) a with 1.7 MeV proton micro beam was carried out into high purity semi-insulating 4H-SiC bulk substrates. Luminescent defects created in the SiC were investigated at room temperature using a confocal laser scanning microscope. A peak around 900 nm associated with the silicon vacancy was observed for the irradiated SiC without any post-implantation processing such as annealing. The overall depth profile of photon counts detected from irradiated areas is in good agreement with simulated vacancy depth profile. This suggests that the silicon vacancy can be applied as an ion tracking detector. In addition, since the silicon vacancy is known as a single photon source with a spin that can be controlled at room temperature, PBW is expected to be a useful tool to fabricate spin qubits.
Conference Proceeding