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"Koehler, Jeff"
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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon
Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination of type I and type II interferon (IFN) responses are highly susceptible to ZIKV infection; however, the absence of a competent immune system limits their usefulness for studying medical countermeasures. Here we employ a murine model for ZIKV using wild-type C57BL/6 mice treated with an antibody to disrupt type I IFN signaling to study ZIKV pathogenesis. We observed 40% mortality in antibody treated mice exposed to ZIKV subcutaneously whereas mice exposed by intraperitoneal inoculation were highly susceptible incurring 100% mortality. Mice infected by both exposure routes experienced weight loss, high viremia, and severe neuropathologic changes. The most significant histopathological findings occurred in the central nervous system where lesions represent an acute to subacute encephalitis/encephalomyelitis that is characterized by neuronal death, astrogliosis, microgliosis, scattered necrotic cellular debris, and inflammatory cell infiltrates. This model of ZIKV pathogenesis will be valuable for evaluating medical countermeasures and the pathogenic mechanisms of ZIKV because it allows immune responses to be elicited in immunologically competent mice with IFN I blockade only induced at the time of infection.
Journal Article
The North African cookbook
\"Extensively researched and twenty years in the making, The North African Cookbook is the largest collection of traditional North African for home cooks. Focusing on the Maghreb region - Morocco, Algeria, Tunisia, and Libya - The North African Cookbook explores the territory's vast culinary diversity and history. From Berber, Arabic, and Ottoman influences as well as French, Spanish, and Italian, this cookbook offers a comprehensive overview of how native, as well as European colonialism, influenced the region's traditions today. A wide network of culinary voices from across North Africa guided the project. In a region so vast and so diverse, James Beard award-winning food writer Jeff Koehler looked to many hundreds of experts and locals. Following two decades of travel across North Africa and a career spent writing in depth about the region and its food, Koehler's extensively researched collection is an exhaustive look at traditional recipes across the Maghreb. Filled with delicious and authentic North African dishes that can easily be recreated at home, this treasure trove of a book brings to life an exciting cuisine that is as varied and fascinating as the countries it covers.\"--Amazon.
BOOK
حيث تنمو القهوة البرية : القصة غير المروية للقهوة من غابات إثيوبيا المكللة بالغمام الى فنجانك
يقدم كتاب (حيث تنمو القهوة البرية) والذي قام بتأليفه \"جيف كوهلير\" معلومات تاريخية وقصص رحالة ويعمل بأسلوب الصحافة الاستقصائية ويبدو البحث عن أصول القهوة مثل قصة شائقة، فهذا الكتاب هو أحد أهم الأعمال عن البن وأكثرها إقناعا في وقتنا الحالي. حكاية غنية بالتفاصيل تلائم الانتشار الواسع للقهوة في مجتمعنا اليوم. لقد أثبت كوهلير بأنه أحد أفضل الكتاب المعاصرين في مجال ثقافة الطعام والشراب وبمقدوره تحويل معلومات تاريخية وعلمية وواقعية إلى سرد مشوق يجعلك تقلب الصفحات باهتمام. سواء كنت تشرب قهوة دنكين دونات من كوب تحمله معك، أو قيشا نمت تحت الظل من كيمكس، ستجعل قصة كوهلير المحبوكة بدقة كوبك الآتي أكثر إمتاعا.
BOOK
How Chocolate Became A Sweet (But Not So Innocent) Consort To Valentine's Day
The company combined cacao powder and sugar with cacao butter (the fat extracted from cacao beans) to form a moldable paste. According to the National Confectioners Association, U.S. consumers will shell out around $1 billion for Valentine's Day candy this year.
Web Resource
When Mr. Coffee Was The Must-Have Christmas Gift For Java Snobs
Holiday wish lists for foodies and coffee snobs this year include Hario V60 ceramic pour-over dripper cones, highly sensitive digital brewing scales, burr grinders and, for stocking stuffers, bags of small-lot Ethiopian and Panamanian beans. In 1977, with ads running during the first commercial break of Roots, Mr. Coffee held a 50 percent share of the American coffee maker market.
Web Resource
How Lipton Built An Empire By Selling 'Farm To Table' Tea
[...]it was sold with the catchy slogan \"direct from tea garden to tea pot.\" [...]the island was still reeling from the collapse of the coffee industry, and land was going for fire-sale prices.
Web Resource
Autumn Flush: The Best Darjeeling Tea You'll (Likely Never) Taste
First flush teas, made as new leaves, stimulated by the first moisture after a winter of dormancy, start appearing on the bushes. Among the top North America purveyors of fine teas that sell Darjeeling tea by estate and flush, neither Harney & Sons nor Tea Trekker offer any, while Upton Tea Imports has just a single autumn flush among the 26 Darjeelings it stocks.
Web Resource