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Screening for cervical cancer is not a component of health care in rural India. This article reports on a trial of cervical-cancer screening by human papillomavirus (HPV) testing, cytologic analysis, or visual inspection of the cervix with acetic acid in rural villages. The results, as compared with those in a group that received no screening, showed that a single round of HPV testing significantly reduced the incidence of invasive cervical cancer and mortality in rural Indian villages. A trial in rural Indian villages of cervical-cancer screening by human papillomavirus (HPV) testing, cytologic analysis, or visual inspection of the cervix with acetic acid showed that a single round of HPV testing significantly reduced the incidence of invasive cervical cancer and mortality. In developing countries, there is a lack of effective screening programs for cervical cancer. In these countries, no clinically significant reduction in the incidence of cervical cancer has occurred during the past three decades. 1 – 4 In developed countries, by contrast, there has been a major decline in cervical-cancer mortality after the introduction of large-scale cytologic testing. The limited success of such screening in developing countries has stimulated evaluation of testing for human papillomavirus (HPV) and visual inspection of the cervix with acetic acid (VIA). In October 1999, we initiated a cluster-randomized, controlled trial to evaluate the effectiveness of a single . . .

A new and elaborate automatic vacuum protection system using fast acting valve has been installed to avoid accidental venting of accelerator from experimental chamber side. To cover all the beam lines and to reduce the system cost, it has been installed at a common point from where all the seven beam lines originate. The signals are obtained by placing fast response pressure sensing gauges (HV SENSOR) near all the experimental stations. The closing time of the fast valve is 10 milli-second. The fast closing system protects only one vacuum line at a time. At IUAC, we have seven beam lines so one sensor was placed in each of the beam lines near experimental chamber and a multiplexer was incorporated into the fast closing system. At the time of experiment, the sensor of the active beam line is selected through the multiplexer and the Fast closing valve is interlocked with the selected sensor. As soon as the pressure sensor senses the pressure rise beyond a selected pressure, the signal is transferred and the fast valve closes within 10 to 12 millisecond.

Local names: Amli, Imli, Chinch. Botanical name: Tamrindus indica Once the city of Mumbai had many tamarind trees Tamarind trees with dark stout bark and a large canopy were a familiar sight along the small roads and outskirts. But now they are much less seen due to...

The mixed ligand complexes of the type MAB, MA2B and MAB2 where M = Pr(III), A = histidine and B = ethanediol, prop-1,2-diol,2-butene-1,4-diol, but-2,3-diol, pent-1,5-diol and hex-1,6-diol have been investigated by alkalimetric titrations. The overall stability constants have been evaluated at 30 + 1°C. (μ = 0.2 M KNO3). The absorption spectra of some praseodymium (III) ternary complexes in solution have been used to calculate energy interaction and intensity parameters. The low intensity of the pseudohypersensitive transition suggests higher coordination number.

Alcohol is a dangerous substance causing global mortality and health issues, including mental health problems. Regular alcohol consumption can lead to depression, anxiety, cognitive decline, and increased risk of alcohol-related disorders. Thus, monitoring ethanol levels in biological samples could contribute to maintaining good health. Herein, we developed an electrochemical sensor for the determination of ethanol in human salivary samples. Initially, the tetra-chloroauric acid (HAuCl4) was chemically reduced using sparfloxacin (Sp) which also served as a stabilizing agent for the gold nanoparticles (AuNPs). As-prepared Sp-AuNPs were comprehensively characterized and confirmed by UV-visible spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and elemental mapping analysis. The average particle size (~25 nm) and surface charge (negative) of Sp-AuNPs were determined by using dynamic light scattering (DLS) and Zeta potential measurements. An activated screen-printed carbon electrode (A-SPE) was modified using Sp-AuNPs dispersion, which exhibited greater electrocatalytic activity and sensitivity for ethanol (EtOH) oxidation in 0.1 M sodium hydroxide (NaOH) as studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). DPV showed a linear response for EtOH from 25 µM to 350 µM with the lowest limit of detection (LOD) of 0.55 µM. Reproducibility and repeatability studies revealed that the Sp-AuNPs/A-SPEs were highly stable and very sensitive to EtOH detection. Additionally, the successful electrochemical determination of EtOH in a saliva sample was carried out. The recovery rate of EtOH spiked in the saliva sample was found to be 99.6%. Thus, the incorporation of Sp-AuNPs within sensors could provide new possibilities in the development of ethanol sensors with an improved level of precision and accuracy.

D.V. Cowen in his popular book \"Flowering trees and shrubs in India\" (1950). writes the following lines while looking at this beautiful Indian Tree.

Introduction: Patient in critical care units (CCUs) are admitted with multiple clinical problems and busy environment with critical situations makes nurses prone to commit mistakes. Thus, the quality checklist helps the staff in providing adequate, safe, and efficient client care. The objective of the present study was to develop quality improvement checklist for nurses working in CCU. Methods: A methodological study was carried out to develop quality improvement checklist for CCU in different phases. Validity was measured in terms of face, content, and construct validity. Modified Delphi technique used for content validity. Construct validity was analyzed by factor analysis. Reliability was investigated in terms of internal consistency of checklist and inter-rater reliability. Results: There were a total of 32 items in the final draft of the checklist. Cronbach’s alpha which 0.78 was. Cohen’s kappa was 0.88. Inter-item correlation was found between 0.2 and 0.7. The content validity index (CVI) was 0.98. All items were loaded in 8 factors and accounted for 60.7% of variance. Conclusion: Quality improvement checklist has good validity and reliability and it can be used to evaluate and improve the quality of CCU.

Perforation peritonitis remains a significant cause of morbidity and mortality in emergency surgical patients. Conventionally, open laparotomy has been the preferred approach. However, with advancements in minimally invasive techniques, laparoscopic management has emerged as a potential alternative. The study aims to assess the feasibility and effectiveness of laparoscopic surgery compared to open laparotomy in managing perforation peritonitis. A prospective observational study was conducted from January 2022 to May 2023 for patients diagnosed with perforation peritonitis. A total of 140 patients were recruited, 110 patients underwent laparotomy while 30 patients underwent laparoscopic management. Propensity score matching (PSM) in 1:1 ratio was applied to balance confounding variables, resulting in two matched groups of 28 patients each. Operative time, length of post-operative stay, post-operative Visual Analogue Scale score, morbidity and mortality rates were compared. The mean operative time was significantly longer in the laparoscopic group (217.43 ± 86.10 min) compared to the laparotomy group (182.46 ± 31.63 min; P = 0.049). However, patients in the laparoscopic group experienced a significantly shorter hospital stay (4.39 ± 2.04 days vs. 8.68 ± 3.45 days; P < 0.001) and lower post-operative pain scores at all time points (P < 0.012). The 30-day morbidity rate was lower in the laparoscopic group (10% vs. 32%), with fewer surgical site infections and reoperations. Laparoscopy is a feasible and effective alternative to laparotomy in selected cases of perforation peritonitis, offering benefits such as reduced post-operative pain and shorter hospital stay. Despite technical challenges, improved surgical expertise and patient selection can enhance its role in emergency surgical settings.

 Anasarca is well-known and refers to generalized edema caused by underlying clinical conditions and unknown risk factors in the patient. However, it is a relatively unexplored postoperative symptom following major abdominal surgeries. It is associated with poor patient outcomes in terms of delayed recovery and associated severe complications. Pedal edema is an early sign of post-operative anasarca, which progresses into an unfavorable clinical condition due to generalized edema followed by multiple organ dysfunction.  Aim: This study aimed to assess risk factors and complications associated with postoperative anasarca among patients undergoing major abdominal surgery.  The prospective observational study included 241 patients undergoing major abdominal surgeries from July 2019 to February 2021 in a tertiary care health centre in Rajasthan, India. Risk factors like age, nutritional parameters, addictions like smoking, alcohol intake, opium intake, leukocytosis, and Charlson Comorbidity Index were assessed. Postoperative complications were graded by the Clavien-Dindo grading system. Mean, standard deviation, percentages, Pearson's Chi-square test and Student's t-test were used to analyze the data.  Results: The incidence of anasarca was found to be 29.87%. Nutritional risk screening (NRS) 2002 score, albumin, age > 60 years and raised leukocyte counts were found to significantly correlate (p-value <0.05) with the development of anasarca postoperatively. Postoperative complications, according to Clavien-Dindo grading, were 16.67% in grade I (p value=0.002), 13.89% in grade II (p-value =0.199), 1.39% in grade III (p value=0.049), 20.83% in grade IV (p value<0.001), and 41.67% in grade V (p value<0.001).  Higher NRS 2002 score, low albumin levels, age > 60 years and raised leukocyte counts are significantly correlated with the development of postoperative anasarca. Postoperative anasarca is found to be a significant predictor of poor prognosis of patients undergoing major abdominal surgery.