Journal Article

HPV Screening for Cervical Cancer in Rural India

Malvi, Sylla G, Kelkar, Rohini, Panse, Nandkumar, Hingmire, Sanjay, Shastri, Surendra S, Muwonge, Richard, Kothari, Ashok, Nene, Bhagwan M, Jayant, Kasturi, Dinshaw, Ketayun A, Sankaranarayanan, Rengaswamy, Chinoy, Roshan, Budukh, Atul M, Rajeshwarkar, Raghevendra, Desai, Sangeetha, Kane, Shubhada, Keskar, Vijay R, Thorat, Ranjit

2009

Overview

Screening for cervical cancer is not a component of health care in rural India. This article reports on a trial of cervical-cancer screening by human papillomavirus (HPV) testing, cytologic analysis, or visual inspection of the cervix with acetic acid in rural villages. The results, as compared with those in a group that received no screening, showed that a single round of HPV testing significantly reduced the incidence of invasive cervical cancer and mortality in rural Indian villages. A trial in rural Indian villages of cervical-cancer screening by human papillomavirus (HPV) testing, cytologic analysis, or visual inspection of the cervix with acetic acid showed that a single round of HPV testing significantly reduced the incidence of invasive cervical cancer and mortality. In developing countries, there is a lack of effective screening programs for cervical cancer. In these countries, no clinically significant reduction in the incidence of cervical cancer has occurred during the past three decades. 1 – 4 In developed countries, by contrast, there has been a major decline in cervical-cancer mortality after the introduction of large-scale cytologic testing. The limited success of such screening in developing countries has stimulated evaluation of testing for human papillomavirus (HPV) and visual inspection of the cervix with acetic acid (VIA). In October 1999, we initiated a cluster-randomized, controlled trial to evaluate the effectiveness of a single . . .

• Publisher: Massachusetts Medical Society
• Subject: Acetic Acid / Adult / Biological and medical sciences / Biopsy / Cervical cancer / Cervical Intraepithelial Neoplasia - diagnosis / Cervical Intraepithelial Neoplasia - epidemiology / Cervical Intraepithelial Neoplasia - virology / Colposcopy / Cytological Techniques / Developing countries / Female / General aspects / Health facilities / Human papillomavirus / Humans / Incidence / India / Industrialized nations / LDCs / Mass Screening - methods / Medical sciences / Middle Aged / Papillomaviridae - isolation & purification / Papillomavirus Infections - diagnosis / Predictive Value of Tests / Prevention and actions / Public health. Hygiene / Public health. Hygiene-occupational medicine / Uterine Cervical Neoplasms - diagnosis / Uterine Cervical Neoplasms - epidemiology / Uterine Cervical Neoplasms - mortality / Uterine Cervical Neoplasms - virology / Womens health