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1 result(s) for "Le Ray, Laure Fournier"
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atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
by Revest, Matthieu , Bonnet, Isabelle , Aubry, Alexandra in Antimicrobial agents , Antitubercular Agents - pharmacology , Antitubercular Agents - therapeutic use
2022
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
Journal Article
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