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atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
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atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
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Journal Article
atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
2022
Overview
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
Publisher
U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
Subject
/ Antitubercular Agents - pharmacology
/ Antitubercular Agents - therapeutic use
/ atpE
/ Diarylquinolines - pharmacology
/ Diarylquinolines - therapeutic use
/ Drug resistance in microorganisms
/ Humans
/ MDR TB
/ Mutation
/ Mycobacterium tuberculosis - genetics
/ Not Always Predictive of Bedaquiline Treatment Failure
/ Rv0678
/ Tuberculosis, Multidrug-Resistant - diagnosis
/ Tuberculosis, Multidrug-Resistant - drug therapy
/ XDR TB
