Explore the vast range of titles available.

A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.

En un mundo en el que el éxito es cada vez más fugaz, las organizaciones y las personas que aspiran a triunfar necesitan incorporar la innovación como parte de su estilo de vida. Sin embargo, ¿cómo se puede fomentar el comportamiento innovador?Ingenio y pasión proporciona una eficaz metodología y una herramienta indispensable para que emprendedores, directivos y responsables de equipos que necesiten inventar y reinventarse encuentren el impulso transformador en su propia fuerza motriz. Para ello aporta herramientas de diagnóstico, directrices de aplicación y lecciones aprendidas por cientos de empresas y profesionales que han triunfado o fracasado en el intento. Gracias a ellas, muestra cómo gestionar con eficacia tres dimensiones esenciales: personas, organización y motivación, contemplando en todo momento las diferencias de género.Esta eficaz metodología, de la que se han hecho eco publicaciones internacionales como Forbes, permite abordar la innovación de una manera rigurosa y práctica, logrando que empresas y profesionales crezcan a pesar de las turbulencias, construyendo las condiciones que garanticen, más allá de la supervivencia, una buena dosis de éxito.

Background/Aims: Heavy ethanol consumption is a risk factor for hypertension and prompts organ damage. There is no information regarding the impact of long-term heavy ethanol consumption on kidney structure and function linking to their hypertensive effects nor the repercussions after withdrawal. Methods: Rats were exposed to ethanol for 24 weeks and, afterwards, a group was assigned to withdrawal for 8 weeks. Blood pressure (BP) was measured and serum biochemical parameters were quantified. Glomerular volume density, areal density of glomerular tuft and renal corpuscles were determined. Angiotensin II type 1 receptor (AT1R) protein expression was evaluated. Results: Twenty-four weeks of ethanol consumption causes atrophy of renal corpuscles and glomeruli and reduces the volume of glomeruli. Glomerular changes induced by ethanol consumption were still evident after withdrawal. Renal AT1R levels were increased in ethanol-treated rats and returned to control levels during withdrawal. Ethanol consumption also induced an increase in BP, uric acid and albumin levels. Upon withdrawal, systolic and mean arterial pressures decreased, but were still higher than in controls rats. Conclusion: Ethanol consumption induces changes in glomerular morphology associated with increased BP and AT1R expression. Long-term withdrawal was inefficient to restore the structural integrity of renal corpuscles and in lowering systolic pressure.

This paper contributes to a better comprehension of the role that place the theory of the creation of the universe in al-Fārābī. To him, God creates the world while thinking about himself. This theory is an adaptation of Plotino's. The al-Fārābī's theory is a rational one, which, in that epoch meant to be according with Science and Philosophical ideas from the Greeks. In those times any theory that purported an explanation of the universe had to attach to the Almagest, which in turn contained the mathematical model from Apolonius and the cosmology according to Ptolemy, although al-Fārābī reduces the celestial spheres to only eleven, and the functioning of these spheres does not obey the physical laws. Al-Fārābī's explanation is rather a psychological one, for he attributes the celestial bodies both an intelligence and a soul similar to the human one, which would gobern its course. This theory is not an adaptation from that of Aristotle, since this supposes an Immobil First Motor, to which all the celestial spheres obey. Also he postulates the impossibility of the universe to be wrotten, since this universe was not created and is eternal. On the contrary, al-Fārābī needs an explanation for the creation of the universe. To this purpose he has resource to the ideas of Plato's Demiurg, which had already been developed by Plotino, in such a way that they were made addaptable to the ideas of Aristotle. God Creator identifies those both with the First Intelligence of Plotino and with the Immobile Motor of Aristotle. Also, al-Fārābī was in the need of explaining this sublunar world, within which the Earth is immerse. For the sake of this purpose he extended to the Moon the same properties than those of the other celestial beings. In this article, it is described the way in which al-Fārābī conects the sublunar world with the terrestrial phenomena. The methodological treatment of this problem is prior to the other mentioned. It is made a rational reconstruction of al-Fārābī's philosophy according to the general precepts of any reconstruction of an ancient theory in a new epoch.

Os fatores culturais influenciam o sucesso da comunicação entre pessoas de origens culturais diversas, todavia podem também ser cruciais quando se trata da realização de um negócio em mercados externos. Deste modo, quando uma empresa pretende ingressar em outros mercados deve primeiramente considerar a cultura do mercado-alvo para que seja possível averiguar como se deverá comportar transculturalmente. A competência cultural tornou-se atualmente uma grande vantagem para as empresas multinacionais. Poder contar com pessoas culturalmente competentes é essencial dado que estão cientes das barreiras que podem ocorrer durante os encontros e comunicações interculturais pois saberão como geri-las de forma a evitar possíveis conflitos. A cultura desempenha um papel relevante quando se negoceia fora. Na área do Marketing compreender e avaliar as diferenças culturais pode ser um fator decisivo, pois pode auxiliar uma empresa a operar eficazmente além-fronteiras, de forma a diminuir a competitividade e a conquistar a sua segmentação de mercado com sucesso.Esta dissertação foca-se em como exatamente a escolha das Estratégias de Marketing por parte de uma empresa afetam o negócio, através da análise de diversos estudos de caso que fornecem uma visão do que deve ser feito e evitado ao distribuir um produto ou serviço num novo mercado. O expectável é reconhecer se a adaptação cultural dessas estratégias influencia, e de que forma, um negócio e se as empresas atingem – ou não – o seu objetivo final. O enquadramento teórico deste estudo foi desenvolvido através da análise do conceito de cultura e de como a comunicação se desenrola entre comunidades distintas, e, o enquadramento prático feito com variados estudos de caso para que ao se interligar com a área do Marketing se entenda como a cultura afeta a disseminação de mensagens. Ademais, este artigo visa examinar como desafios no marketing transcultural podem ser contornados através do conhecimento e competências em culturas estrangeiras.

La presente investigación, de interés en salud pública en el área de Odontología, evaluó la acción de tres desinfectantes (glutaraldehído, hipoclorito de sodio y cloruro de benzalconio) frente a superficies susceptibles con mayor contaminación bacteriana en unidades dentales de uso continuo, comparando la población bacteriana antes y después de la desinfección. Se seleccionaron tres superficies (jeringa triple, testera de la silla, escupidera) por medio de cuestionarios al personal de las clínicas odontológicas de la Universidad Antonio Nariño - Sede Sur. Los microorganismos encontrados fueron similares para todas las unidades dentales, con prevalencia de Gram negativos no fermentadores en mayor proporción, seguido de fermentadores, Gram positivos y esporulados. Se logró la mayor eliminación de microorganismos por el protocolo de desinfección con glutaraldehído al 2%, seguido de hipoclorito de sodio al 0,5 % y cloruro de benzalconio al 1%.

This chapter highlights how a human focused approach to fostering digital participation engaged local communities and schools with issues of sustainability and climate change. We describe a series of four socially engaged, interactive artistic interventions that took place across forests, urban and rural environments in the United Kingdom and Brazil between 2009 and 2015. These projects used sensing and online technologies to exchange information between communities in the United Kingdom and Brazil to engage with their local environments, presenting a framework that focused on the human element of human–computer interaction specifically supporting sensory and embodied experiences of scientific data. These approaches encourage digital inclusion and interdisciplinary thinking about local and global issues of deforestation and climate change. The authors argue that an abundance of opportunities, networks and local knowledge can be mediated through both digital and analogue technologies, in order to provide truly ‘lived’ experiences of environmental and digital participation.