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"Lee, Shannon"
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Making bank : money skills for real life
\"The definitive young readers' guide to tracking, saving, spending, enjoying and growing money. \"No one knows what money will be like when you grow up. But here's the thing: life costs money. That has always been true and will still be true when you're grown up. Whether you're using babysitting money to buy takeout coffee with your pals today or trading digital tokens to buy an electric hovercar in twenty years, the same skills you must use to afford your Starbucks this week will be used tomorrow and every day after. Learn and practise just five skills around money today and you'll be ready to take on the world, no matter how much things change in five years or fifty years. You got this.\" Told through a series of conversations, helpful guides, easy tables and definitions, Making Bank invites young readers to discuss a subject that is easy to avoid: money. With her signature charm, Shannon Lee Simmons transforms the thornier aspects of finance into easy-to-understand concepts. Whether it's figuring out how to save for a senior-year trip, wondering what the heck inflation is or trying to wrap your mind around credit, interest and crypto, Shannon approaches every subject with expertise and empathy. By focusing on how to track, save, spend, enjoy and grow their money, Making Bank rebuilds young readers' relationship with it--one skill at a time.\"-- Provided by publisher.
BOOK
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly discuss new findings in the extracellular signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress activated MAPK pathways, such as p38 MAPK and the Jun N-terminal kinases (JNK), impact the response of cancer cells to chemotherapies and targeted therapies. In this context, we also discuss the role of metabolic and epigenetic aberrations and new therapeutic opportunities arising from these changes.
Journal Article
The new death : mortality and death care in the twenty-first century
The New Death brings together scholars who are intrigued by today's rapidly changing death practices and attitudes. New and different ways of treating the body and memorializing the dead are proliferating across global cities. Using ethnographic, historical, and media-based approaches, the contributors to this volume focus on new attitudes and practices around mortality and mourning—from the possibilities of digitally enhanced afterlives to industrialized \"necro-waste, \" the ethics of care, the meaning of secular rituals, and the political economy of death. Together, the chapters coalesce around the argument that there are two major currents running through the new death—reconfigurations of temporality and of intimacy. Pushing back against the folklorization endemic to anthropological studies of death practices and the whiteness of death studies as a field, the chapters strive to override divisions between the Global South and the Anglophone world, focusing instead on syncretization, globalization, and magic within the mundane.
eBook
Munchausen Syndrome by Proxy in Singapore
Aims: Munchausen syndrome by proxy, or “factitious disorder imposed on another” as per DSM–V criteria, is characterised by the falsification of signs or symptoms, or induction of injury or disease, in another individual. Despite its initial description over 60 years ago, the literature on its epidemiology, management, and prognosis remains limited, with most insights derived from isolated case reports. Methods: We report a case of a 27-year-old woman charged with attempted murder after injecting her 7-year-old son with insulin multiple times. The patient’s actions were driven by a history of severe childhood trauma, including sexual abuse by her father and brother, which contributed to her distorted perceptions of her son’s behaviour. She falsely presented symptoms to healthcare providers, altered diagnostic tests, and fabricated medical histories, resulting in extensive and unnecessary investigations for the child on top of complications from being injected by insulin. Psychiatric evaluation diagnosed her with major depressive disorder, post-traumatic stress disorder, antisocial personality traits, and Munchausen syndrome by proxy. Despite being aware of the harm caused by her actions, the patient’s judgement was significantly impaired due to her mental illnesses. Treatment included antidepressants and psychotherapy, with partial improvement observed. Results: This case illustrates the significant risks posed by Munchausen syndrome by proxy to victims and the complexities involved in its diagnosis and management. Early identification requires a high index of suspicion and meticulous investigation by multidisciplinary teams. Video surveillance and psychiatric evaluations are crucial tools in confirming such cases. Long-term management often necessitates pharmacological treatment and tailored psychotherapy for the perpetrator, alongside safeguarding measures for the victim. Conclusion: Munchausen syndrome by proxy remains a challenging diagnosis requiring vigilance and interdisciplinary collaboration. This case underscores the importance of early recognition to prevent harm to victims and highlights the need for systematic research to explore common patterns and effective interventions in this rare condition.
Journal Article
The Bruce Lee way
This fascinating collection showcases how Bruce Lee lived and how we can all live better, fuller lives by following his example. Bruce Lee was more than a movie star or a martial artist. For many people, he was a living example of the incredible things a person can accomplish through dedication, perseverance and sheer force of will. In just 33 years before his untimely death, Bruce Lee created new styles of fighting, and became an international film star, television personality, philosopher and cultural icon in the process. This inspirational new book presents a carefully curated selection of photos, stories, anecdotes and ephymera, plus favorite film notes, lines and commentary from friends, family, peers and rivals. It distills the iconic fighter's approach to making the most out of life into a beautifully bound book that would be treasured by any Bruce Lee fan, as well as those readers looking for an inspired approach to living a richer, more fulfilling existence.
Book
Talking Trash and the Politics of Disregard
One of my favourite photos of my son is him as an over-tired, dishevelled and very disgruntled five-year-old. He stands, holding out two globs of unidentifiable rusted metal, and looks at the camera (at me), with an accusing, penetrating glare (Fig. 1). As a distracted, overextended parent trying to run an archaeological field project (the Rising Sun Hotel in New Orleans), I had sent him to play in the dirt—the back dirt of our discard pile. I thought that's where he couldn't get into any trouble. I didn't imagine that it would get me into trouble. He was mad because we had overlooked these obvious artefacts (he had already grasped the subtle nature/culture distinction of the archaeological sorting process). We had disregarded them. We had attempted to make them unworthy of notice. What my son, in his innocence, was enunciating is the intentionality of ignoring something—and with intentionality, there is always a potential politics. That is what I would like to focus on here: how can we approach Beiläufigkeit—the incidental and taken-for-granted—as indexical of politics?
Journal Article
Molecular mechanisms of azole resistance in Candida bloodstream isolates
Background
Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of
Candida
spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.
Methods
Twenty-six azole non-susceptible
Candida
spp. clinical isolates were investigated. Antifungal susceptibilities were determined using the Sensititre YeastOne® YO10 panel. The
ERG11
gene was amplified and sequenced to identify amino acid polymorphisms, while real-time PCR was utilised to investigate the expression levels of
ERG11
,
CDR1
,
CDR2
and
MDR1
.
Results
Azole cross-resistance was detected in all except two isolates. Amino acid substitutions (A114S, Y257H, E266D, and V488I) were observed in all four
C. albicans
tested. Of the 17
C. tropicalis
isolates, eight (47%) had
ERG11
substitutions, of which concurrent observation of Y132F and S154F was the most common. A novel substitution (I166S) was detected in two of the five
C. glabrata
isolates. Expression levels of the various genes differed between the species but
CDR1
and
CDR2
overexpression appeared to be more prominent in
C. glabrata
.
Conclusions
There was interplay of various different mechanisms, including mechanisms which were not studied here, responsible for azole resistance in
Candida
spp in our study.
Journal Article
Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells
Decorin (DCN) is an important small leucine-rich proteoglycan present in the extracellular matrix (ECM) of many organs and tissues. Endothelial progenitor cells (EPCs) are able to interact with the surrounding ECM and bind to molecules such as DCN. Here, we recombinantly produced full-length human DCN under good laboratory practice (GLP) conditions, and after detailed immunological characterization, we investigated its potential to attract murine and human EPCs (mEPCs and hECFCs). Electrospun polymeric scaffolds were coated with DCN or stromal cell-derived factor-1 (SDF-1α) and were then dynamically cultured with both cell types. Cell viability was assessed via imaging flow cytometry. The number of captured cells was counted and compared with the non-coated controls. To characterize cell-scaffold interactions, immunofluorescence staining and scanning electron microscopy analyses were performed. We identified that DCN reduced T cell responses and attracted innate immune cells, which are responsible for ECM remodeling. A significantly higher number of EPCs attached on DCN- and SDF-1α-coated scaffolds, when compared with the uncoated controls. Interestingly, DCN showed a higher attractant effect on hECFCs than SDF-1α. Here, we successfully demonstrated DCN as promising EPC-attracting coating, which is particularily interesting when aiming to generate off-the-shelf biomaterials with the potential of
in vivo
cell seeding.
Journal Article