Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
39,628
result(s) for
"Li, Sheng Li"
Sort by:
الحياة
صدرت حديثا عن مؤسسة بيت الحكمة، سلسلة \"قصص الرموز الصينية\"، وهي أول سلسلة تثقيفية وتعليمية مترجمة تتناول البحث في قصص الرموز الصينية، والكشف عن أصل الرموز والحكايات التاريخية التي خلفها، حيث تعتمد على مقولات مبسطة تقود القارئ لمعرفة منابع الرموز الصينية وتاريخ تطورها. وتتشكل السلسلة من خمسة كتب، وهي \"الإنسان، والحيوان، والنبات، والطبيعة، والحياة\"، ويتناول كل منها عددا من الرموز التي يحكي أصلها وطرق كتابتها على مر العصور وصولا لشكلها الحالي، بالإضافة إلى التعريف بأشكال النقوش وأنواع الخطوط الصينية ونماذج لكل منها، والطرق الأساسية لابتكار الرموز الصينية إما المعبرة عن الأشياء، أو المشتقة من معنى أجزائها، كما تتناول السلسلة، الكلمات والعبارات التي تدخل الرموز في تكوينها، والأمثال والحكم والقصص التراثية التي تستخدم الرمز أو مدلولاته في إطار أدبي شيق.
Book
Current status of immunotherapy for non-small cell lung cancer
Nowadays, lung cancer is still the deadliest oncological disease in the world. Among them, non-small cell lung cancer (NSCLC) accounts for 80%∼85% of all lung cancers, and its 5-year survival rate is less than 15%, making the situation critical. In the past decades, despite some clinical advances in conventional treatments, the overall survival rate of NSCLC is still not optimistic due to its unique physiological conditions and the frequent occurrence of tumor escape. In recent years, immunotherapy has become a new hot spot in lung cancer research, including antibody therapy and cell therapy, which have been developed and utilized one after another, especially immune checkpoint inhibitor (ICI). These approaches have effectively improved the overall survival rate and objective response rate of NSCLC patients by enhancing the immune capacity of the body and targeting tumor cells more effectively, which is more specific and less toxic compared with conventional chemotherapy, and providing more strategies for NSCLC treatment. In this paper, we reviewed the relevant targets, clinical progress and adverse reaction in monoclonal antibodies, antibody-drug conjugates, ICI, bispecific antibodies, T-cell receptor engineered T cell therapy (TCR-T), Chimeric antigen receptor T-cell immunotherapy (CAR-T), and also report on their combination therapy from the immune-related background to provide better NSCLC treatment and prospective.
Journal Article
وجوه لا تلتقيها مرتين : حكايات غير عادية عن أبطال عاديين
\"وجوه لا تلتقيها مرتين\" يروي حكايات غير عادية عن أبطال عاديين، ربما تجدهم في مجتمعك بغض النظر عن طبيعة تكوين هذا المجتمع أو نطاقه الجغرافي أو خلفياته الثقافية والاقتصادية، وهو كتاب واقعي غير مثالي، تعرض فيه الصحفية الشهيرة لي يوان تشنغ الأحداث الخفية والتفاصيل المبهمة التي أفرزت التنمية الصينية الهائلة، والنقلة الاجتماعية كتجربة غير مسبوقة، ولكن من منظور إنساني، فهو لا يتطرق إلى استراتيجيات ولا سياسات ولا خطط خمسية، بل يركز على الفرد، كونه إنسانا فحسب.
Book
Etiological and epidemiological features of acute respiratory infections in China
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and
Streptococcus pneumoniae
,
Mycoplasma pneumoniae
and
Klebsiella pneumoniae
are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients’ demography, geographic locations and season of illness in China.
China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.
Journal Article
Ankle and Foot Spasticity Patterns in Chronic Stroke Survivors with Abnormal Gait
Chronic stroke survivors with spastic hemiplegia have various clinical presentations of ankle and foot muscle spasticity patterns. They are mechanical consequences of interactions between spasticity and weakness of surrounding muscles during walking. Four common ankle and foot spasticity patterns are described and discussed through sample cases. The patterns discussed are equinus, varus, equinovarus, and striatal toe deformities. Spasticity of the primary muscle(s) for each deformity is identified. However, it is emphasized that clinical presentation depends on the severity of spasticity and weakness of these muscles and their interactions. Careful and thorough clinical assessment of the ankle and foot deformities is needed to determine the primary cause of each deformity. An understanding of common ankle and foot spasticity patterns can help guide clinical assessment and selection of target spastic muscles for botulinum toxin injection or nerve block.
Journal Article
كتاب الحیاة : (رواية)
تحكي هذه الرواية قصة حياة فتى ريفي يتحول عالمه بعدما خرج من قريته الفقيرة إلى المدينة القريبة، ثم إلى العاصمة المليئة بالضجيج، عبر الإجابة عن تساؤلات عدة منها : ما البيئة التي خرج منها ؟ ومن صادف خلال رحلته ؟ وإلام ستصير حياته ؟ وكيف انتهت كل تلك الحكايات ؟ وهي ليست مجرد رحلة كفاح لفتى ريفي في المدينة، بل رحلة حياة كاملة أو هي سجل للحياة \"أي حياة\". حصل المؤلف \"لي باي فو\" عن هذه الرواية على جائزة \"ماودون في الأدب\" وهي أرفع جائزة أدبية في الصين أو كما يطلق عليها \"نوبل الصينية\" وتمنح كل أربع سنوات لخمسة أدباء صينيين.
BOOK
FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer
Background
The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC).
Methods
One hundred and six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples and NSCLC cell lines were used to examine FOXP3 and its related molecules. Various cell functions related to tumorigenesis were performed. In vivo mouse tumor xenograft was used to confirm the in vitro results.
Results
NSCLC patients with the high level of FOXP3 had a significant decrease in overall survival and recurrence-free survival. FOXP3 overexpression significantly induced cell proliferation, migration, and invasion, whereas its inhibition impaired its oncogenic function. In vivo studies confirmed that FOXP3 promoted tumor growth and metastasis. The ectopic expression of FOXP3 induced epithelial–mesenchymal transition (EMT) with downregulation of E-cadherin and upregulation of N-cadherin, vimentin, snail, slug, and MMP9. The oncogenic effects by FOXP3 could be attributed to FOX3-mediated activation of Wnt/β-catenin signaling, as FOXP3 increased luciferase activity of Topflash reporter and upregulated Wnt signaling target genes including c-Myc and Cyclin D1 in NSCLC cells. Co-immunoprecipitation results further indicated that FOXP3 could physically interacted with β-catenin and TCF4 to enhance the functions of β-catenin and TCF4, inducing transcription of Wnt target genes to promote cell proliferation, invasion and EMT induction.
Conclusions
FOXP3 can act as a co-activator to facilitate the Wnt-b-catenin signaling pathway, inducing EMT and tumor growth and metastasis in NSCLC.
Journal Article
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
It is thought that KRAS oncoproteins are constitutively active because their guanosine triphosphatase (GTPase) activity is disabled. Consequently, drugs targeting the inactive or guanosine 5′-diphosphate–bound conformation are not expected to be effective. We describe a mechanism that enables such drugs to inhibit KRASG12C signaling and cancer cell growth. Inhibition requires intact GTPase activity and occurs because drug-bound KRASG12C is insusceptible to nucleotide exchange factors and thus trapped in its inactive state. Indeed, mutants completely lacking GTPase activity and those promoting exchange reduced the potency of the drug. Suppressing nucleotide exchange activity downstream of various tyrosine kinases enhanced KRASG12C inhibition, whereas its potentiation had the opposite effect. These findings reveal that KRASG12C undergoes nucleotide cycling in cancer cells and provide a basis for developing effective therapies to treat KRASG12C-driven cancers.
Journal Article