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Fashion brand management : plan, scale and market a successful fashion business
\"How do you develop an effective strategy for launching a fashion brand? What marketing activities do you need to undertake to identify and engage with your customers? How are new technologies shaping business models? This definitive guide explains the realities of the fashion industry. Fashion Brand Management is an introduction to how to operate a fashion business in a multi-trillion revenue industry. Written by a leading innovator in the fashion industries, it's a guide to conceptualizing, developing and building a successful brand. It explains key need-to-know marketing and branding models and shows you how to apply them successfully to your business, such as Porter's Five Forces and Generic Strategy, Kapeferer's Brand Identity Prism, the 10 Ps of marketing, how to differentiate your value proposition using Sinek's Golden Circle and Greiner's Growth Strategy. Fashion Brand Management looks at the key challenges facing today's fashion industry and explores the ways in which both micro-brands and international businesses need to adapt. It explore issues such as an uneven recovery, logistics gridlock, the impact of the metaverse, the circular economy, digital only collections, social selling and see-now-buy-now. Using case studies from a range of brands and covering luxury, mainstream and discount, this textbook is supported by online resources which include questions, extra resources and lecture notes\"-- Provided by publisher.
Book
Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy would prevent urinary tract infection in children (under the age of 18 years) who had already had one or more microbiologically proven urinary tract infections. Long-term, low-dose trimethoprim–sulfamethoxazole was associated with a modest decrease in the number of urinary tract infections in predisposed children.
Long-term, low-dose trimethoprim–sulfamethoxazole was associated with a modest decrease in the number of urinary tract infections in predisposed children.
Urinary tract infection is a very common illness in children, affecting 2% of boys and 8% of girls by the age of 7 years.
1
Urinary tract infection is associated with long-term morbidity, with renal damage reported in about 5% of affected children.
2
The observation that urinary tract infection and vesicoureteral reflux are associated with renal damage
3
–
5
led to the standard clinical practice of assessment with voiding cystourethrography for the presence of vesicoureteral reflux in children who had had urinary tract infection
6
,
7
and the administration of daily low-dose antibiotics for many years
8
to prevent further urinary tract infections and . . .
Journal Article
The Long-Term Safety of Topical Corticosteroids in Atopic Dermatitis: A Systematic Review
Topical corticosteroids (TCS) are a first-line treatment for eczema, but there are concerns about their safety when used long-term.
To systematically review adverse effects associated with longer-term use of TCS for eczema.
Randomised controlled trials (RCTs), cohort and case-control studies reporting adverse effects of TCS (comparators: no TCS treatment, other topicals) in patients with eczema were identified. Included studies had greater than one year of follow-up, minimum cohort size of 50 participants, or minimum 50 per arm for RCTs. Evidence was GRADE-assessed. Prospero registration CRD42021286413.
We found seven studies (two randomised, five observational); two RCTs (
= 2570, including 1288 receiving TCS), two cohort (all received TCS
= 148) and three case-control studies (cases
= 10 322, controls
= 12 201). Evidence from two RCTS (
= 2570, children, three and five years' duration) comparing TCS to topical calcineurin inhibitors found intermittent TCS use probably results in little to no difference in risk of growth abnormalities, non-skin infections, impaired vaccine response and lymphoma/non lymphoma malignancies. The five-year RCT reported only one episode of skin atrophy (
= 1213 TCS arm; mild/moderate potency), suggesting TCS use probably results in little to no difference in skin thinning when used intermittently to treat flares. No cases of clinical adrenal insufficiency were reported in 75 patients using mild/moderate TCS in the three-year RCT. Small associations between TCS and type-2 diabetes and lymphoma were identified in two case-control studies compared to no TCS, but the evidence is very uncertain. No long-term studies concerning topical steroid withdrawal or eye problems were identified.
This review provides some reassuring data on growth and skin thinning when TCS are used intermittently for up to 5 years, but many knowledge gaps remain.
Journal Article
Physiological impacts of Mg deficiency in Pinus radiata: growth and photosynthesis
This paper reports the effects of nutrient magnesium (Mg) concentrations on the growth and photosynthetic
physiology of clonal Pinus radiata from four female parents (families) known to differ in their tolerance to Mg
deficiency and in their needle Mg concentrations. Plants were grown in flowing nutrient solutions with 2 mg l−1
(control) and 0.8 mg l−1 (low) Mg. Plant growth, needle Mg concentration, photosynthesis, chlorophyll
fluorescence and carotenoid pigment content were measured. At low Mg, needle Mg concentration was about half
that of control plants, height growth was reduced 15–25%, and the needles showed strong visual characteristics
of Mg deficiency. Photosynthesis was also halved, and was associated with closure of the stomata under low Mg
and with reductions in the residual conductance. In needles from plants grown at low Mg, photochemical yield
was reduced both in the light and in the dark, and was strongly dependent on needle Mg concentrations below a
threshold concentration of 0.02–0.025% (d. wt basis). The electron transport rate (ETR) at saturating photon flux
density in low-Mg-grown needles was reduced to about half that of their Mg controls, but the photon efficiency
of ETR was unaffected by the Mg concentration the plants were grown in. Photosynthetic quenching was
markedly reduced and non-photosynthetic quenching was increased following growth in low Mg. Growth under
low Mg also increased levels of zeaxanthin. Although family differences in growth and photosynthetic physiology
were present, few family × Mg interactions were significant. We conclude that Mg deficiency probably affects
growth through severe reductions in photosynthesis.
Journal Article
Parental consent to participation in a randomised trial in children: Associated child, family, and physician factors
Background
Low participation rates in randomised controlled trials involving children are almost a universal problem, leading to high cost and low statistical power. Trial, parent/family, child, and physician factors have been reported to influence parental willingness to consent for paediatric trials.
Purpose
To identify modifiable and unmodifiable factors associated with parental consent.
Methods
Demographic and clinical characteristics of children and their families and physician characteristics associated with parental consent were evaluated in a recent randomised placebo-controlled trial of prophylactic antibiotics to prevent recurrent urinary tract infection.
Results
Of 1109 eligible children identified (mean age, 2.0 years), 412 parents (37.2%) consented. On a multivariate analysis, the only modifiable factor associated with consent was request for consent by a member of the research study team rather than by a member of the clinical team (risk ratio (RR) = 1.9, 95% confidence interval (CI): 1.2–2.9). The unmodifiable factors significantly associated with consent were age of the child (≥4 years) (RR = 1.2, 95% CI: 1.1–1.4), presence of vesicoureteric reflux (RR = 1.5, 95% CI: 1.3–1.8), inpatient management of the index infection (RR = 0.8, 95% CI: 0.7–0.9), and multiple (≥4) symptoms at presentation (RR = 1.3, 95% CI: 1.1–1.5).
Limitations
We have reported data from only one of the four participating centres in this trial. Data on non-consenters in other participating centres were not completely collected. Data on characteristics of the recruiting physician were limited. These findings are applicable for those considering a single randomised controlled trial.
Conclusions
Parent, child, and physician factors are associated with consent for trial participation, with most not being modifiable. Having a member of the research study team approach the parent for consent appears to be the only feasible strategy for increasing recruitment to randomised trials in this setting.
Journal Article
Predicting phosphorus requirements of young Pinus radiata using sequential Bray soil extraction
We used data from 33 field experiments with 4 year old Pinus radiata in which response to phosphate fertilisers was measured. We divided the data into two categories: one in which there was cultivation and weed control, and one in which there was neither because interactions between effects of fertilisation and those of weed control are common. We used the ratio of stem volume index between unfertilized and fertilized trees as a measure of the response. We measured Bray P as an indicator of inorganic phosphorus (P) availability in the soils, and continued the extraction for a total of ten times in order to reflect the ability of the soil to continue to supply P. Responses of trees to phosphate fertilisation were related to Bray P by a Mitscherlich equation. The equation differed between the two categories. The soils differed in the extent to which they were able to maintain supply to the repeated extractions. With some soils, the amounts extracted declined rapidly with successive extractions; with others they declined less rapidly and in some soils the second extraction removed more phosphate than the first extraction. The cumulated amount of extracted P (y) was described as a function of the number of extractions (N) using the equation, y = αN b where b = βN γ . In this equation, the β parameter was a measure of the ability of the soils to maintain phosphorus supply under repeated extraction. When this parameter was added to a modified Mitscherlich equation, r-squared increased from 0.495 to 0.644 for the data in which there was weed control or soil cultivation. Response to fertilisation was significantly (P = 0.001) better predicted by the repeated Bray P extraction modelling procedure than it was by a single Bray P extraction for each soil among data from plots with either weed control or cultivation. In soils that lacked both weed control and cultivation interactions between effects of weed competition and fertilisation very likely contributed to the lack of any clear relationships between repeated Bray P extractions and response to fertilisation. Further validation of the results reported here may lead to better predictions of effects of fertilisation on crop growth from soil samples.
Journal Article
The cutting edge of dental instruments
Develop good sharpening skills and your instruments will reward you with a long, trouble-free working life, says dental hygienist Alison Lowe*.
Journal Article